Mihail G. Chelu, MD, PhD

Physician-scientist | Professor | Director Research @Texas_Heart and Director of EP @BCMHouston | co-PI with @KennethEllenbo1 of @leftvsleft RCT

[Heart Rhythm Society @HRSonline]

NEW EPISODE OF THE LEAD!

[Ep. 146] A Discussion of LEAP2: A First-In-Human Study of a Chronically-Implanted Novel Leadless Pacemaker for Conduction System Pacing

🎙️ Host: Christopher C Cheung, MD, MPH, FHRS (@ChrisCheungMD)
🎤 Guests: Derek Chew, MD, MS, FHRS (@derek_c1) and Mihail G. Chelu, MD, PhD, FHRS (@MihailChelu)

Listen on your preferred podcast platform
➡️

https://t.co/VXfAm8TCpL

#EPeeps #medpod #podcast #CardioTwitter #EPTwitter #PodcastAndChill

[JAMA @JAMA_current]

#HeartFailure (HF) affects more than 64 million individuals worldwide, and acute HF is associated with 1-year mortality rates of 23.6% in North America and Europe.

Cardiac resynchronization therapy restores synchronous ventricular activation in patients with HF, reduced LVEF, and left bundle-branch block, or in those requiring chronic ventricular pacing, and may improve LV function, decrease HF hospitalizations, and reduce mortality. 🧵

🔗 Learn more in this JAMA Review: https://t.co/HYZqQg8rzi

[Mihail G. Chelu, MD, PhD @MihailChelu]

Our newest review on CRT is online in JAMA:
https://t.co/OyHNmjYARs @KennethEllenbo1 @CaiqueTernesMD

[Mihail G. Chelu, MD, PhD @MihailChelu]

Our lead extraction experience @Texas_Heart and @bcmhouston published online in Cardiovascular Drugs and Therapy.
https://t.co/gXYpxOxXtf

[Texas Heart Institute @ Baylor College of Medicine @Texas_Heart]

New in The New England Journal of Medicine: Physiologic Pacing in Heart Failure by @MihailChelu. The review summarizes how physiologic pacing has improved outcomes in heart failure.
Read more: https://t.co/Y146T6D9RM

[NEJM @NEJM]

Cardiac physiologic pacing can be achieved with biventricular pacing with a right ventricular lead and coronary sinus lead or conduction system pacing by way of the His bundle or left bundle branch. It is indicated in patients with heart failure, left ventricular ejection fraction (LVEF) of 50% or less, and high or anticipated high ventricular pacing burden and left ventricular resynchronization in patients with a wide QRS complex.

His bundle pacing is the most physiologic pacing mode, because it preserves the natural activation of the left and right ventricles. It is indicated in patients with atrioventricular nodal and intra-Hisian conduction system disease that is associated with symptomatic bradycardia. His bundle pacing can also correct left bundle-branch block in the subgroup of patients who have disease in the His–Purkinje fibers that become the left bundle branch.

Left bundle-branch pacing requires the implantation of a pacing lead through the interventricular septum to the left ventricular subendocardial left bundle branch or its fascicles. This procedure has rapidly become the dominant conduction system pacing approach owing to its higher success rate and lower and more stable pacing thresholds than those obtained with His bundle pacing, and because it provides correction of left bundle-branch block due to disease below the level of the His bundle (seen in figure).

Learn more in the Review Article “Physiologic Pacing in Heart Failure” by @MihailChelu, MD, PhD, Jeanne E. Poole, MD, and Kenneth A. Ellenbogen, MD (@KennethEllenbo1), from the Baylor College of Medicine (@bcmhouston), University of Washington (@UW), and Virginia Commonwealth University School of Medicine: https://t.co/RuLZCpYUXn

[NEJM @NEJM]

A new review summarizes cardiac physiologic pacing for heart failure, highlighting benefits of biventricular pacing and emerging evidence for His-bundle and left bundle-branch pacing to improve function and outcomes.

Read the Review Article “Physiologic Pacing in Heart Failure” by @MihailChelu, MD, PhD, Jeanne E. Poole, MD, and Kenneth A. Ellenbogen, MD (@KennethEllenbo1), from the Baylor College of Medicine (@bcmhouston), University of Washington (@UW), and Virginia Commonwealth University School of Medicine: https://t.co/RuLZCpYUXn

[NEJM @NEJM]

A new review summarizes cardiac physiologic pacing for heart failure, highlighting benefits of biventricular pacing and emerging evidence for His-bundle and left bundle-branch pacing to improve function and outcomes.

Figure 2 from the review shows His bundle pacing on electrocardiogram (ECG).

Panel A shows an ECG of right ventricular pacing with a paced QRS duration (QRSd) of 190 msec. In this patient, who had complete heart block at baseline and a left ventricular ejection fraction (LVEF) of 60 to 65%, pacing-induced cardiomyopathy developed, leading to a LVEF of 35 to 40% with 100% right ventricular pacing.

Panel B shows an ECG of His bundle pacing with a paced QRSd of 82 msec. Upgrading the patient’s pacemaker to a His bundle pacemaker improved the LVEF to a range of 60 to 65%.

Learn more in the Review Article “Physiologic Pacing in Heart Failure” by @MihailChelu, MD, PhD, Jeanne E. Poole, MD, and Kenneth A. Ellenbogen, MD (@KennethEllenbo1), from the Baylor College of Medicine (@bcmhouston), University of Washington (@UW), and Virginia Commonwealth University School of Medicine: https://t.co/RuLZCpYUXn

[BCM Clinician Resources @BCMCME]

HEART ALERT ❤️‍🔥
Next week’s the big week! Join top experts at the Ali Massumi Symposium—where innovation pulses.
👉 Register now: https://t.co/jsEWDDMWO6

@Texas_Heart @BCMHeart @BCM_Alumni @tcainstitute

[Giuseppe Biondi-Zoccai @gbiondizoccai]

Must-read review in the latest issue of the NEJM on physiologic pacing in HF https://t.co/wHfnLSY95N @NEJM

[NEJM @NEJM]

Cardiac physiologic pacing, also known as cardiac resynchronization therapy, is indicated in patients with heart failure, reduced left ventricular ejection fraction (LVEF) of 50% or less, and either a high (or anticipated high) ventricular pacing burden or a wide QRS complex. Traditionally, physiologic pacing has been achieved with biventricular pacing with a right ventricular lead and a coronary sinus branch lead. Randomized trials involving more than 10,000 patients with heart failure have shown clinical, exercise, and quality-of-life benefits associated with biventricular pacing, as well as improved LVEF and reduced mitral regurgitation and ventricular volumes. These benefits are greatest in patients with left bundle-branch block and a QRS duration of 150 msec or longer. Recent studies support targeting the His bundle or left bundle branch as an alternative cardiac physiologic pacing strategy. Ongoing randomized trials are expected to more clearly define the comparative efficacy and safety of conduction system pacing as compared with biventricular pacing.

Read the Review Article “Physiologic Pacing in Heart Failure” by @MihailChelu, MD, PhD, Jeanne E. Poole, MD, and Kenneth A. Ellenbogen, MD (@KennethEllenbo1), from the Baylor College of Medicine (@bcmhouston), University of Washington (@UW), and Virginia Commonwealth University School of Medicine: https://t.co/RuLZCpYUXn

[Mihail G. Chelu, MD, PhD @MihailChelu]

Spreading the gospel to a wider audience with Drs. Jeanne Poole and Kenneth Ellenbogen @KennethEllenbo1.
@PCORI @LeftvsLeft @bcmhouston @bcmcvri

[NEJM @NEJM]

Cardiac physiologic pacing, also known as cardiac resynchronization therapy, is indicated in patients with heart failure, reduced left ventricular ejection fraction (LVEF) of 50% or less, and either a high (or anticipated high) ventricular pacing burden or a wide QRS complex. Traditionally, physiologic pacing has been achieved with biventricular pacing with a right ventricular lead and a coronary sinus branch lead. Randomized trials involving more than 10,000 patients with heart failure have shown clinical, exercise, and quality-of-life benefits associated with biventricular pacing, as well as improved LVEF and reduced mitral regurgitation and ventricular volumes. These benefits are greatest in patients with left bundle-branch block and a QRS duration of 150 msec or longer. Recent studies support targeting the His bundle or left bundle branch as an alternative cardiac physiologic pacing strategy. Ongoing randomized trials are expected to more clearly define the comparative efficacy and safety of conduction system pacing as compared with biventricular pacing.

Read the Review Article “Physiologic Pacing in Heart Failure” by @MihailChelu, MD, PhD, Jeanne E. Poole, MD, and Kenneth A. Ellenbogen, MD (@KennethEllenbo1), from the Baylor College of Medicine (@bcmhouston), University of Washington (@UW), and Virginia Commonwealth University School of Medicine: https://t.co/RuLZCpYUXn

[BCM Clinician Resources @BCMCME]

📅Mark your Calendar for the Ali Massumi Cardiac Arrhythmia Symposium 2026

📍The Westin Houston Medical Center
January 31, 2026

Register here: https://t.co/vKBjHhz9sW

@Texas_Heart @BCMHeart @bcmhouston #CardioEd @MihailChelu

[Margarida Pujol Lopez @MargaridaPujol]

@MihailChelu #bestSlide

[HeartRhythm @hrs_journal]

Hierarchical Physiologic Pacing to Enhance Clinical Outcomes in Conduction System Pacing
#HRS2025 #LBCT

@shunmug_his_mdu

https://t.co/kWQTQFBl8U

[HeartRhythm @hrs_journal]

Left Bundle Branch Area Pacing Compared to Biventricular Pacing for Cardiac Resynchronization Therapy in Patients with Left Ventricular Ejection Fraction ≤50%: Results from the Intl Collaborative LBBAP Study (I-CLAS)
#HRS2025 #LBCT
@pvijayaraman1
https://t.co/9zfLeAUfkq

[Heart Rhythm TV @HeartRhythmTV]

Immediately following the #LBCT presentation at #HRS2025, Heart Rhythm TV host @Nashwa_Salem_ sat down with @Hisdoc1 to discuss Left Bundle Branch Area Pacing Compared To Biventricular Pacing in Candidates for Cardiac Resynchronization Therapy (LVEF <50%): Results From International Collaborative LBBAP Study (I-CLAS). See the full interview here ➡️ https://t.co/94Rie49Pax

[Roderick Tung @DrRoderickTung]

Our new Madam President, Dr. Mina Chung to lead @HRSonline! 🎊
Incredible and tireless leadership from Dr. Ellenbogen, thank you for a great year. 🙏

[Circulation @CircAHA]

#ICYMI: The TRAVERSE Trial #AHAJournals @williamdillonmd @ed_gerst @DrRoderickTung
@JonHsuMD @MihailChelu @Zo_EP @EhdaieMD
@B_Naz_MD @JDMossMD @tjaredbunch
@ABeaser @AlexiosHadjis

[Circulation @CircAHA]

@williamdillonmd
@ed_gerst
@DrRoderickTung @JonHsuMD
@MihailChelu
@Zo_EP2
@EhdaieMD
@B_Naz_MD
@JDMossMD
@tjaredbunch
@ABeaser @boatnoodlesoup
@AlexiosHadjis @gregorymmarcus