Leishmaniases comprise clinically distinct diseases caused by the protozoan parasite leishmania, transmitted through the bite of infected sand flies. A new review summarizes current approaches and recent advances in the diagnosis and treatment of leishmaniasis. Full review: https://t.co/N3LaviIpzU
Presented at #ASCO26:
Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: https://t.co/xwLWBZYRzq
@ASCO
When I applied to medical school in 1996, lots of people (attendings, residents, some family members) told me the profession was doomed because of HMOs, longer hours, and lower pay. It's been 30 years, and medicine is still in demand, with excellent job security. Don't let the current fatalists get you down. The world will always need doctors.
after more than ten years of approval, the PCSK9 inhibitors seem to finally have been shown to lower mortality.
Evolocumab finally seems to work as primary prevention of myocardial infarction
85 to 90 percent of women physicians are eldest daughters.
That is not a coincidence. That is a pipeline.
Eldest daughters are trained, before age five, to over-function. They take on a parent's worry. They organize the family. They clean up without being asked. They do not ask for help, because they were rewarded their whole childhood for not needing any.
Then they walk into medicine.
A career that demands hyper-responsibility, hypervigilance, perfectionism, and silent sacrifice does not have to ask these women to give those things. They were giving them before they could read.
The system is not stumbling into a burnout problem. The system is recruiting from a pool of people whose entire childhood was a training program for it.
This is what pediatrician and certified coach Jessie Mahoney has been finding when she asks the room. In every group, in every retreat. Maybe one or two women are not eldest daughters. The rest have been carrying something since before they could spell their own name.
Most of those women blame themselves. "Why don't I have boundaries?" "Why do I over-function?" "Why can't I delegate?"
Because at five years old, your family rewarded you for over-functioning. Because every teacher praised you for it. Because the medical training system selected for it. Because every job since has reinforced it. The pattern is older than your medical degree by twenty years.
The other piece nobody names: by the time these women are in their fifties, they are carrying eldest-daughter responsibility for aging parents AND running a department as chief AND running a household. The role does not retire when the children do. It just compounds.
Jessie's reframe is the part worth bookmarking.
The "hero" framing is the trap. Eldest daughters were made the savior of the family before they could read. Then medicine made them the savior of the patient. Then the department made them the savior of the team. At every stage, they learned that if they did not do it, terrible things would happen and it would be their fault.
Awareness is the first move. Non-judgment is the second. Excellence is not doing everything yourself. Excellence is letting other people do their jobs.
You are allowed to gift some of it back. You can ask your siblings to carry the aging parent. You can let your medical assistant do the medical assistant's job. You can stop covering the gap that nobody actually asked you to cover.
Most eldest daughters in medicine have never asked for help. When they finally do, they discover people are willing to help. The asking was the whole obstacle.
Listen to the full conversation on The Podcast by KevinMD. Link in the replies.
What is the one task you have been carrying for your family or your team that no one ever actually asked you to carry?
#ThePodcastbyKevinMD
Physicians are under more pressure than ever. From administrators, from insurers, from legislatures, from a public that increasingly questions our expertise.
Nobody is going to advocate for us if we don't advocate for each other.
"Cefazolin does not share any side chains with the currently available penicillins and can be used in cases of suspected or proven immediate type allergy to a penicillin, irrespective of severity or time elapsed since the index reaction."
⭐Surgical prophylaxis
⭐MSSA infection
Review on mucormycosis @NEJM
✨5 pillars for successful treatment:
➡️Early detection and staging
➡️Timely initiation of antifungal
➡️Surgical resection of infected tissue
➡️Reversal of immunodeficiencies
➡️Correction of metabolic abnormalities
https://t.co/vvISbFZ6VT