Adam Mulkern

Postdoc, MacLean lab, experimental evolution, AMR 🧬 @UniofOxford

[Adam Mulkern @MulkernAdam]

Excited to share something from my previous postdoc with @mgalactus, a collaboration with the @JoergLab using lab evolution to see how different bacterial species develop resistance to programmable antibiotics:
https://t.co/894LEV1Oeg

[Stefan O. Bassler @StefanBassler]

The increased mutation rate of DNA-repair–deficient mutators accelerates resistance evolution in bacteria and cancer. In a great collaboration with @MulkernAdam, we find that DNA-damaging antibiotics can turn this advantage into a liability—but only for certain genotypes.

[Adam Mulkern @MulkernAdam]

Evolution-aware therapies need to be genotype-directed!

Thanks to @StefanBassler, @wtmatlock, @typaslab, @craigmaclean

[Adam Mulkern @MulkernAdam]

Cancer therapies exploit DNA repair defects to kill tumours. We asked whether the same logic could constrain antibiotic resistance evolution...

https://t.co/5yLOkjGolB

[Adam Mulkern @MulkernAdam]

We paired antibiotics with DNA-damaging agents and evolved a panel of E. coli repair mutants using high-throughput evolution at EMBL. Some hypermutators were constrained, but the strategy only works if you match the damage to the specific repair defect...

[Adam Mulkern @MulkernAdam]

Still buzzing after the @MicrobioSoc meeting on 'Understanding and Predicting Microbial Evolutionary Dynamics' last week. It was great to connect with so many people who share the same type of science. Big thanks to the organisers for the opportunity to present my research too!

[Adam Mulkern @MulkernAdam]

Had a short but sweet visit to Zürich to speak at @ETH_en. Many thanks to @phagemuffin and @AHarms485!

[Adam Mulkern @MulkernAdam]

What a month...I spent June in the US at the @CSHL Advanced Bacterial Genetics course and then the @GordonConf Molecular Mechanisms in Evolution! I met so many cool people along the way — special shoutout to my course lab partner, Max!

[Adam Mulkern @MulkernAdam]

Hopped over to Northern Ireland last week to give a talk at @QUBelfast for their AMR seminar series. Thanks very much to @WheatleyRM, @LindaOyama, and @sharonhuws for hosting me!

[Adam Mulkern @MulkernAdam]

@StefanBassler @embl @UniofOxford Sounds like a solid plan to me!

[Adam Mulkern @MulkernAdam]

Wrapped up 2024 with the @TypasLab in Heidelberg @embl, doing some evolution experiments with @StefanBassler. Had an incredible time and looking forward to an exciting year of science in 2025!

[Helmholtz Institute Würzburg (HIRI) @Helmholtz_HIRI]

Stress-testing #asobiotics…🦠 @MulkernAdam & @mgalactus from TWINCORE, in collaboration with #HIRI’s @JoergLab, have employed in-vitro laboratory evolution to study how different bacteria develop resistance to programmable antibiotics. Check out their preprint to learn more. 👇

[Adam Mulkern @MulkernAdam]

@JoergLab Challenge accepted!

[Adam Mulkern @MulkernAdam]

A cool post about the paper too by @mgalactus: https://t.co/xoyspNXtjX

[Adam Mulkern @MulkernAdam]

Excited to share something from my previous postdoc with @mgalactus, a collaboration with the @JoergLab using lab evolution to see how different bacterial species develop resistance to programmable antibiotics:
https://t.co/894LEV1Oeg

[Adam Mulkern @MulkernAdam]

Big shoutout to these 3 from the MacLean Lab, currently in SF, who just launched Evolvere BioSciences on
@ycombinator!

'Making next-generation antibiotics that outsmart bacterial evolution'
Take a look and drop them an upvote! https://t.co/TxItixxmME

[Adam Mulkern @MulkernAdam]

@StefanBassler @TypasLab @embl @UniHeidelberg @EMBLHeidelberg HUGE congrats man!!!

[Rachel Wheatley @WheatleyRM]

Published today in @EvolLetters 🎉🎉
Antibiotic resistance alters the ability of Pseudomonas aeruginosa to invade bacteria from the respiratory microbiome https://t.co/WDcZ92TAmX
A short thread 🧵:

[Adam Mulkern @MulkernAdam]

@HannahVallin Ahhh yessss, congrats!!!!!

[Adam Mulkern @MulkernAdam]

Had a fun day visiting @AdamWinnifrith at @TheCrick and got to check out their epic lab setup!