Neural Stem Cell Research Lab

🧠 Modelling neurodegenerative diseases
💼 Job openings

National Neuroscience Institute

[Neural Stem Cell Research Lab @NSCRLab]

We are looking for a motivated #bioinformatician (immediate position) to analyze #transcriptomic data on #neurodegenerative diseases to join our lab. All PhD, MSc and BSc with relevant experience are welcome to apply!

https://t.co/bfQYRes1JT

[Neural Stem Cell Research Lab @NSCRLab]

Our lab is at the #ADPD2023!! First physical international conference in 3 years! @adpdnet

[Neural Stem Cell Research Lab @NSCRLab]

Check out our latest study on the effects of itanapraced on #Parkinsons disease! Thanks @mnt for the feature 👍🏼

[Medical News Today @mnt]

Alzheimer’s drug candidate may have potential for treating Parkinson’s disease https://t.co/22wREJdDUG #ScienceTwitter

[Society of Developmental Biologists Singapore @devbio_sg]

Upcoming ⁦ @devbio_sg virtual ⁩seminar by Associate Professor Quenten Schwarz on interneuron development, happening on 27 October! ⁦ @phil1pingham @MonteiroLab @onsunlau_nus @NSCRLab @HongyanWang9 @Yusuke_Toyama @ReversadeLab @unisaresearch

[Society of Developmental Biologists Singapore @devbio_sg]

Upcoming exciting ⁦@devbio_sg⁩ seminar by Anna Akhmanova on #microtubules! ⁦@phil1pingham⁩ ⁦@MonteiroLab⁩ ⁦@onsunlau_nus⁩ ⁦@NSCRLab⁩ @HongyanWang9⁩ ⁦@Yusuke_Toyama⁩ ⁦@ReversadeLab⁩

[StemCellSocSin @StemCellSpore]

SCSS Symposium 2022: Registration is open - https://t.co/9daE5yIWtk

[Neural Stem Cell Research Lab @NSCRLab]

Thanks for the feature! @Ingentium_PD The APP intracellular domain promotes LRRK2 expression to enable feed-forward neurodegenerative mechanisms in Parkinson's disease. https://t.co/5Jam7ZoUUa

[Science Signaling @scisignal]

An experimental therapy for Alzheimer’s disease can break a molecular loop and protect neurons in mouse models of Parkinson’s disease, hinting similar approaches could prove beneficial for this incurable neurodegenerative condition. @NSCRLab #Neuroscience https://t.co/CnM01xJwWh

[The Science of Parkinson's @ScienceofPD]

Annovis Bio @AnnovisBio has announced that the 1st patient in the Phase 3 clinical trial evaluating buntanetap (aka ANVS401, Posiphen) in early stage #Parkinsons has been dosed; The trial will enroll a total of 450 participants, treatment for 6 months
https://t.co/QfFjrxRifA

[Neural Stem Cell Research Lab @NSCRLab]

@HongyanWang9 @scisignal Thanks Hongyan! 😁

[Neural Stem Cell Research Lab @NSCRLab]

Just today, our paper on a feed-forward loop between the APP intracellular domain (AICD) fragment and the kinase LRRK2 which promotes #Parkinsonsdisease pathology was published on @scisignal #ScienceSignalingResearch
https://t.co/SV3snhPKCR

[Neural Stem Cell Research Lab @NSCRLab]

We propose that AICD cooperates with transcription factor of FOXO3a to promote LRRK2 transcriptional activation and expression. Experimental drug, itanapraced, inhibits LRRK2-mediated neurotoxicity. @ScienceMagazine @scisignal #Parkinsonsdisease

[Neural Stem Cell Research Lab @NSCRLab]

@ScienceMagazine @scisignal Thanks for the shout out!

[Science Magazine @ScienceMagazine]

An experimental treatment for Alzheimer’s disease can break a molecular loop and protect neurons in mouse models of #ParkinsonsDisease, suggesting similar approaches could prove beneficial for this incurable neurodegenerative condition. https://t.co/nwWa3iKMeU @SciSignal

[Science Signaling @scisignal]

A positive feedback loop between AICD and #LRRK2 drives #neurodegeneration and mitochondrial dysfunction in #ParkinsonsDisease but can be targeted with the experimental drug itanapraced, show experiments in mice from the Tan and Zeng labs. @mysgh @NSCRLab https://t.co/6KXzTFAHQw

[Neural Cell News @NeuralCell]

New paper from the @NSCRLab! They found that in cultured neurons & brain tissue from mouse models of #ParkinsonsDisease, LRRK2-mediated phosphorylation of APP increased the abundance and activity of the APP intracellular domain. 🧠

@scisignal
https://t.co/uZwqFKFCNG

[Science Signaling @scisignal]

A self-sustaining molecular loop that drives Parkinson’s disease can be targeted in mice, new research answers a longstanding question about Wnt signaling, and more in this week’s new issue of Science Signaling. https://t.co/1UBtpxSaCA

[Neural Stem Cell Research Lab @NSCRLab]

We found that blood miR-150-5p was upregulated in #AlzheimersDisease #Dementia which could be a promising cost-effective and non-invasive biomarker for AD. Read our article published in @journal_ad!
https://t.co/mOeSx2T2jM

[Neural Stem Cell Research Lab @NSCRLab]

@Haitao_Tu

[Neural Stem Cell Research Lab @NSCRLab]

Earlier this year, we published on @BioMedCentral reporting the increased expression of pathological markers in Parkinson’s disease dementia post-mortem brains compared to dementia with Lewy bodies. Check it out! #Parkinsonsdisease #lewybody
https://t.co/NxReb6UGF6