We are looking for a motivated #bioinformatician (immediate position) to analyze #transcriptomic data on #neurodegenerative diseases to join our lab. All PhD, MSc and BSc with relevant experience are welcome to apply!
https://t.co/bfQYRes1JT
Thanks for the feature! @Ingentium_PD The APP intracellular domain promotes LRRK2 expression to enable feed-forward neurodegenerative mechanisms in Parkinson's disease. https://t.co/5Jam7ZoUUa
An experimental therapy for Alzheimerās disease can break a molecular loop and protect neurons in mouse models of Parkinsonās disease, hinting similar approaches could prove beneficial for this incurable neurodegenerative condition. @NSCRLab#Neuroscience https://t.co/CnM01xJwWh
Annovis Bio @AnnovisBio has announced that the 1st patient in the Phase 3 clinical trial evaluating buntanetap (aka ANVS401, Posiphen) in early stage #Parkinsons has been dosed; The trial will enroll a total of 450 participants, treatment for 6 months
https://t.co/QfFjrxRifA
Just today, our paper on a feed-forward loop between the APP intracellular domain (AICD) fragment and the kinase LRRK2 which promotes #Parkinsonsdisease pathology was published on @scisignal#ScienceSignalingResearch
https://t.co/SV3snhPKCR
We propose that AICD cooperates with transcription factor of FOXO3a to promote LRRK2 transcriptional activation and expression. Experimental drug, itanapraced, inhibits LRRK2-mediated neurotoxicity. @ScienceMagazine@scisignal#Parkinsonsdisease
An experimental treatment for Alzheimerās disease can break a molecular loop and protect neurons in mouse models of #ParkinsonsDisease, suggesting similar approaches could prove beneficial for this incurable neurodegenerative condition. https://t.co/nwWa3iKMeU @SciSignal
A positive feedback loop between AICD and #LRRK2 drives #neurodegeneration and mitochondrial dysfunction in #ParkinsonsDisease but can be targeted with the experimental drug itanapraced, show experiments in mice from the Tan and Zeng labs. @mysgh@NSCRLab https://t.co/6KXzTFAHQw
New paper from the @NSCRLab! They found that in cultured neurons & brain tissue from mouse models of #ParkinsonsDisease, LRRK2-mediated phosphorylation of APP increased the abundance and activity of the APP intracellular domain. š§
@scisignal
https://t.co/uZwqFKFCNG
A self-sustaining molecular loop that drives Parkinsonās disease can be targeted in mice, new research answers a longstanding question about Wnt signaling, and more in this weekās new issue of Science Signaling. https://t.co/1UBtpxSaCA
We found that blood miR-150-5p was upregulated in #AlzheimersDisease#Dementia which could be a promising cost-effective and non-invasive biomarker for AD. Read our article published in @journal_ad!
https://t.co/mOeSx2T2jM
Earlier this year, we published on @BioMedCentral reporting the increased expression of pathological markers in Parkinsonās disease dementia post-mortem brains compared to dementia with Lewy bodies. Check it out! #Parkinsonsdisease#lewybody
https://t.co/NxReb6UGF6