David Meredith

Neuropathologist; Cancer genomics research; Assistant Professor, Harvard Medical School @BrighamWomens @BWHPath

[David Meredith @NeuropathDM]

Thanks for including me in this great work!

[Wenya Linda Bi @wenyalindabi]

We’re excited to share our study looking at molecular classification and survival of 4,400 #gliomas @NeuroOnc

A huge team effort over the years @MGBNeurosurgery @BWHNeurosurgery @DanaFarber, here’s what we found. 1/10

https://t.co/sJeO49FjlO

[Kun-Hsing Yu @kunhsingyu]

Excited to share that our paper on a foundation AI model for cancer prognosis and pathology diagnosis is published in Nature today. https://t.co/HShXzxVeZE @HarvardDBMI @NIH @NIGMS @CDMRP @AmericanCancer #AI #DigitalPathology

[My Neuropath News @NeuropathClinic]

cIMPACT-NOW Update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas #neuropath
https://t.co/ZXcRZ2e1i8

[David Meredith @NeuropathDM]

@MAHoureih @DrJPLow EBV+ SMTs usually have an evident lymphocytic infiltrate and varying amounts of fascicular regions with blunted nuclei and primitive round cell areas. This tumor has a more uniform appearance with tapered “neural” nuclei to me. Any history of immunodeficiency?

[David Meredith @NeuropathDM]

@MAHoureih @CraigHorbinski @JaredAhrendsen @astroade @padmapathology1 @NRiddleMD @vi_monappa @mlage @brainpathol @ijexpafo @MishiePishi @afgao @kelly_mrachek @NeuropathClinic @neuropath_uk @cherrycyho @drmbuckland @IntSocNeuropath @HopkinsNeuropth @DrGeeONE @DrRanasaleh @xenaalabbas @01sth02 @JMGardnerMD @Greg_Charville Favor MPNST. Great location, and the immunoprofile fits (CD34+, negative nerve sheath markers in higher grade tumors). Too fascicular for SFT, odd place for monophasic synovial sarcoma, which is usually CD34-.

[David Meredith @NeuropathDM]

@DrJPLow @JaredAhrendsen @DrGeeONE @neuropathology @PriyankaKembha3 @Path4People @TristanRutland7 Papillary glioneuronal tumor has to be at the top of the differential. The location and perivascular cuboidal cells are classic.

[Keith Ligon @KeithLigon5]

Not before your pathologist does! Important opportunity for pathologists and other diagnosticians to communicate their results directly to patients and explain results. Patients need to advocate for this as it’s not currently supported by insurance. #pathology

[David Meredith @NeuropathDM]

Glad to finally have our work on ROS1-rearranged gliomas in diverse age groups published!

#Neuropath #PathTwitter #pathX #pathology

https://t.co/IWrfJGzxuu

[David Meredith @NeuropathDM]

Thanks for including me in this exciting work!

[Kun-Hsing Yu @kunhsingyu]

Excited to share our new paper: AI and digital pathology enable real-time diagnoses and molecular subtype predictions during cancer surgery. https://t.co/OGRd2kX4Yf @MacNasrallah @JuzZ_AI_Mopho ChengCheTsai @NeuropathDM @ElianaMarostica @KeithLigon5 @Jeff_golden1 @HarvardDBMI

[BWH Neuropathology @BWHNeuropath]

Partially demyelinated axons of the cauda equina in the setting of Powassan Infection, presented by our Clinical Fellow, Dr. Kate Krause @pathonthewing #neuropathology #neurotwitter #infectiousdisease

[Brendan Dickson, MD @B_C_Dickson]

MALIGNANT PERIPHERAL NERVE SHEATH TUMOUR. Underlying NF1. IHC: SOX10, H3k27me3. NB: spindle-epithelioid cells with pale amphophilic cytoplasm; ovoid-round nuclei with moderate pleomorphism and conspicuous mitotic activity; variable collagenous-myxoid stroma.

[David Meredith @NeuropathDM]

@FelipePatologia PML - SV40/polyoma to confirm.

[David Meredith @NeuropathDM]

@M_Jikurashvili @atman_ci @JMGardnerMD @nusrat_xahra @nucleololailo I think you have to ignore the MDM2; it’s staining the endothelial nuclei strongly but is negative in the larger atypical cells.

[David Meredith @NeuropathDM]

Rare example of chondroma arising in the dura (falx). Histo shows characteristic mature hyaline cartilage with increased cellularity and mild nuclear atypia.

#pathology #PathTwitter #BSTpath #Neuropath

[David Meredith @NeuropathDM]

Additional IHC (CD99+/des+/SSTR2-) was highly characteristic of Intracranial Mesenchymal Tumor, FET::CREB fusion positive. EWSR1 FISH showed rearrangement. This particular case has a solid growth pattern with no myxoid stroma.

#Neuropath #pathology #PathTwitter #BSTpath

[David Meredith @NeuropathDM]

Not all EMA+ tumors in the dura are meningiomas. Do you recognize this one?
(EMA immunostain is shown for reference.)
#pathology #PathTwitter #Neuropath #BSTPath

[David Meredith @NeuropathDM]

@MariaGoobs Nailed it!

[David Meredith @NeuropathDM]

A good clue is the presence of lymphoglandular bodies in the background. Smear prep is probably the best way to diagnose CNS lymphoma at frozen section.

Here is the accompanying H&E permanent section and CD20.
#PathTwitter #pathology #Neuropath #hemepath

[David Meredith @NeuropathDM]

Can you diagnose in one cell?

(Smear preparation from an enhancing deep white matter frontal mass in an older patient.)
#Pathology #PathTwitter #Neuropath

[BWH Neuropathology @BWHNeuropath]

Welcome to our new #PathMatch2023 AP/NP residents! Alicia Kenyon, MD from Sidney Kimmel Medical College at Thomas Jefferson Univ & Denis Smirnov, MD, PhD from Univ of California San Diego School of Medicine 🧠🔬#neuropath #PathTwitter @BrighamWomens @BostonChildrens @MGHPathology

[David Meredith @NeuropathDM]

Nice example of a clear cell meningioma with the characteristic "blocky" collagen and absence of SMARCE1 expression.