Long-Fei Wu

Doing useless and having fun

[Long-Fei Wu @Nodragonfly]

@KeJahnke small vesicles also do

[Long-Fei Wu @Nodragonfly]

@SaurjaDasGupta @theserbianator I need to google te word "unabashed"😂

[Long-Fei Wu @Nodragonfly]

@theserbianator Thanks, Aleks

[J. Am. Chem. Soc. @J_A_C_S]

Template-Free Assembly of Functional RNAs by Loop-Closing Ligation @MRC_LMB @HarvardCCB @harvardmed @MGHMedicine @Harvard #Template #Assembly #RNA #Loop #Closing #Ligation
https://t.co/1nn6yq72N7

[Long-Fei Wu @Nodragonfly]

New retrosynthetic strategy is now avalaible when assembling structured, functional RNAs from short pieces @Harvard_Origins @MRC_LMB Thanks all the great collaborators @Liu_Ziwei_Tom @SamRobe22992890 @SzostakLab and John and Meng. https://t.co/zy5qz4tSsu

[Long-Fei Wu @Nodragonfly]

As simple as possiple, UV irradiating bicarbonate and bisulfite gives biologically relavent organics in high yielding termed carboxylsulfite chemistry, can it be simpler? Congrats to @Liu_Ziwei_Tom and the collaborators.

[Liu Ziwei @Liu_Ziwei_Tom]

My 2nd @NatureChemistry paper. Simply shining UV light to bicarbonate and sulfite, more than nine compounds came out and the yield can reach nearly 70%. Please check https://t.co/eKfkcDjR1S

[Long-Fei Wu @Nodragonfly]

Congrats to Jimmy and the Sutherland group. Intriguing role of the volcano gas, SO2, (could be prevailing on early Earth and Mars) again in prebiotic chemistry in generating the letters of life.

[jimmy-mrc @JimmyLmb]

Another good paper about R/DNA building blocks.
https://t.co/b840sdv2ng

[Long-Fei Wu @Nodragonfly]

@zakir_tnimov Thank you, Zakir.

[J. Am. Chem. Soc. @J_A_C_S]

Efficient interstrand aminoacyl transfer from an aminoacyl phosphate mixed anhydride at the 5′-terminus of a tRNA acceptor stem mimic to the 2′,3′-diol terminus of a short 3′-overhang https://t.co/hIVyuWpWbl

[Chemical Communications @ChemCommun]

Available now: 'pH-Dependent peptide bond formation by the selective coupling of α-amino acids in water' by Long-Fei Wu & John D. Sutherland #openaccess 🔓 ⬇️ https://t.co/L6b9WUqrDI

[Long-Fei Wu @Nodragonfly]

Alkaline lake with bicarbonate and sulfite, shining UV light on, you will expect to get C1 to C4 carboxylate species, including acetate, glycolate,oxalate, malonate and tartrate etc. Completely different mechanism to modern biology of synthesising them!

[Liu Ziwei @Liu_Ziwei_Tom]

#CarbonDioxide #photoredox to carboxylates (up to tartrate). After one day irradiation, more than 60% of carbon dioxide converted to carboxylates. Please check the fresh paper @ChemRxiv . Thanks for the co-authors. @Nodragonfly and who are not on twitter. https://t.co/sGuhWCRZa2

[Xiaohan Li @xlichem]

This is so cool!

[Long-Fei Wu @Nodragonfly]

@drsaidulislam @Liu_Ziwei_Tom Thanks Saidul. The selectivity isn't good enough. Might be your recent results in Science can rescue the selectivity when an aminonitrile is incorporated. However, we believe in the best selectivity would come from a coding process.

[Long-Fei Wu @Nodragonfly]

We have found a novel mechanism of choosing α-amino acid among various amine nucleophiles when forming peptide bond in acidic aqueous solution, thanks to the intrinsic chemical property of α-amino acids! Thanks to @Liu_Ziwei_Tom and the boss John. https://t.co/TrEjuRPu21

[Nature Chemistry @NatureChemistry]

And finally, all of the prebiotic chemistry-related content, as well as some relevant pieces from our archive, are rounded up on this page: https://t.co/sVmAZnN1vU
Image credit: Ziwei Liu, MRC – Laboratory of Molecular Biology/NASA and NSSDCA

[Long-Fei Wu @Nodragonfly]

Finally, our work is on @NatureChemistry, @MRC_LMB @issol_society @Harvard_Origins @emergenceoflife ,thanks to all the collaborators @Liu_Ziwei_Tom @JimmyLmb @ClaudiaBonfio, & David. Paper is here https://t.co/4ce9kIj8we, also a story "behind the paper", https://t.co/V5y1rJ3YGs

[Long-Fei Wu @Nodragonfly]

Thank you, Paul!