O'Donnell Lab

Scientist in the Department of Molecular Biology at UTSW. We investigate mechanisms of tumorigenesis.

[O'Donnell Lab @ODonnellLab_K]

Excited to share our latest study published in @ScienceAdvances. With the An & Zhang labs @UTHealthHouston, we show that monoclonal antibodies targeting PCDH7 inhibit tumor growth and enhance immune responses in multiple KRAS-mutant lung cancer models.
https://t.co/nL75KoAgGe

[O'Donnell Lab @ODonnellLab_K]

Therefore, these mAbs could potentially benefit patients with multiple tumor types in addition to lung cancer./end

[O'Donnell Lab @ODonnellLab_K]

Excited to share our latest study published in @ScienceAdvances. With the An & Zhang labs @UTHealthHouston, we show that monoclonal antibodies targeting PCDH7 inhibit tumor growth and enhance immune responses in multiple KRAS-mutant lung cancer models.
https://t.co/nL75KoAgGe

[O'Donnell Lab @ODonnellLab_K]

While our work has focused on the role of PCDH7 in lung cancer, PCDH7 is highly expressed in several other tumor types including pancreatic cancer, melanoma, & prostate cancers. PCDH7 has also been shown by others to promote brain metastasis.

[O'Donnell Lab @ODonnellLab_K]

We celebrated Hari’s graduation as he moves on to start a postdoc with @JWHarbourMD. Good luck Hari!

[O'Donnell Lab @ODonnellLab_K]

Congratulations Dr. Hari Shankar Sunil!! @UTSWCancerBio @UTSWGradSchool #ProudPI

[O'Donnell Lab @ODonnellLab_K]

Congratulations to Steven Hepensteil for passing his qualifying exam!

[O'Donnell Lab @ODonnellLab_K]

@shruthy_suresh @IGIBSocial Looking for a great lab and mentor at @IGIBSocial. Look no further. Way to go Shruthy! I am very proud of you!! @UTSWMedCenter @UTSWCancerBio @UTSWMolBiol @utswcancer

[Shruthy Suresh (Aggarwal) @shruthy_suresh]

Delighted to share my research journey, dreams & about our lab at @IGIBSocial in the first episode of the #MeetThePI series. Hopeful for awesome science with my awesome team. I plan to take a talented & passionate PhD student in December, please apply to IGIB if interested.

[Walter W. Chen, MD, PhD @WalterWChen1]

Thrilled to share that I’ll be starting my lab as an Assistant Professor and Endowed Scholar in @UTSWMedCenter Molecular Biology Dept this Fall! 🥳 We’ll study #peroxisomes #mitochondria #metabolism via the lens of neonatology👶🏻, a very exciting frontier in medicine! #neotwitter

[Lowe Lab @LoweLabMSKCC]

Excited to share our latest work, out now in @CellCellPress! Led by @ZedaZhang, we uncover a convergent uPAR⁺ tumor ecosystem that creates broad vulnerability to CAR T cell therapy. A collaborative effort with @Michel_Sadelain and @Aveline_Filliol.
https://t.co/U3M9LECtaY

[O'Donnell Lab @ODonnellLab_K]

Congratulations Kim!!

[Wert Laboratory @WertLaboratory]

UTSW’s Kim Orth receiving the 2026 Earl and Thressa Stadtman Distinguished Scientist Award from Margaret Phillips and Joan Conaway. She gave a great lecture! @UTSWScience @utswnews @ASBMB #ASBMB26

[Wert Laboratory @WertLaboratory]

UTSW’s Kim Orth receiving the 2026 Earl and Thressa Stadtman Distinguished Scientist Award from Margaret Phillips and Joan Conaway. She gave a great lecture! @UTSWScience @utswnews @ASBMB #ASBMB26

[Esra Akbay @EsraAkbay_]

What a great @AACR conference this was. Honored to be sitting among legends @kevansf @RonDePinho and soaking in so much insight and experience. #AACRras26 @utswcancer

[Children’s Research Institute at UT Southwestern @CRI_UTSW]

ONLINE now in @CellCellPress: A review by CRI's @Zhu_Lab about their #relentlessdiscovery and how somatic mutations are becoming a key discovery engine for disease genetics. Read more ➡️
https://t.co/eBm71TT67s