Weiner Lab

Molecular logic of complex cell behaviors.
Orion Weiner's lab @UCSF. Account run by lab members. #CellMigration #CellPolarity #Mechanics #OptoTools

[Weiner Lab @OWeinerLab]

We made it to the cover 🤩 !

[Journal of Cell Biology @JCellBiol]

Our August cover image shows the localization of the WAVE complex (solid colors) and cell edge (dotted lines) of a migrating neutrophil-like HL-60 cell over time. From Pipathsouk, @OWeinerLab et al. (https://t.co/53ncei858s).
Read JCB August Issue: https://t.co/eOCeDplBJH

[Vibha Singh @SVibha1]

👇Take a look at my new @preLights post!
"Rac and Rho team up! Long-distance mechanochemical coordination for migration". Highlighting amazing @biorxiv_cellbio #preprint from lab of @OWeinerLab @HerveTurlier and lead author @Henry_de_belly
https://t.co/qqtrImQi8L

[Dr. Janis Burkhardt @BurkhardtLab]

Henry De Belly's elegant work on front-rear coupling during cell migration is out in bioRxiv! Being a part of this work has been a blast. https://t.co/Cuf9ArcPye

[Henry De Belly @Henry_de_belly]

Hello everyone, excited to share our preprint: https://t.co/DoThdFBDLT
----
Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate? Lets chat!

[Weiner Lab @OWeinerLab]

✨Check out the lab's latest bioRxiv ✨

We explore how cells use long-range mechanochemical feedback to establish and maintain polarity during cell migration!

[Henry De Belly @Henry_de_belly]

Hello everyone, excited to share our preprint: https://t.co/DoThdFBDLT
----
Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate? Lets chat!

[Weiner Lab @OWeinerLab]

✨Pre-print time!✨

Excited to share Kirstin Meyer’s latest work showing how Yap charge patterning mediates transcriptional co-condensate formation! Fantastic collab with @BoHuangLab, Kiersten Ruff, & @ShuLab2010 🤩

https://t.co/Nwev3DvZZr

[Henry De Belly @Henry_de_belly]

Happy to share the review Orion & I wrote for Current Opinion in Cell Biology ! @OWeinerLab

https://t.co/pvkcpfTVpr

[Developmental Cell @Dev_Cell]

Online now: Self-extinguishing relay waves enable homeostatic control of human neutrophil swarming https://t.co/6AdAmZse8O

[Weiner Lab @OWeinerLab]

We are thrilled to see Evelyn's paper on neutrophil swarming out in @Dev_Cell!! Congrats to all authors on this beautiful story! 🎉

Check out the 🎆 thread below ⤵️

[Weiner Lab @OWeinerLab]

✨Pre-print alert!! ✨

Check out Muziyue’s incredible thesis work ➡️ “The WAVE complex forms linear arrays at negative membrane curvature to instruct lamellipodia formation”

[Muziyue Wu @MuziyueW]

Super excited to share my thesis work!

doi:https://t.co/w6apJ2tNvf

We found how cells manage to build the extremely flat and thin membrane protrusions with the WAVE complex, that organizes into a linear polymer-like structure at the tips of lamellipodia.

[Qin Ni @QinNi09]

We @SXS_biophysics wrote an insight article on the brilliant work by @tlngy, @strickland_ev, and @OWeinerLab! Combining a classical Percoll assay with CRISPR screening, they reveal how neutrophils use water to migrate and the involvement of PI3K and NHE1. Check it out!

[Ben Winer @BenjaminYWiner]

Our paper on PM abundance as a regulator for myeloid function is out at SI https://t.co/L5IMjE8TIi!  I would like to thank my mentors Morgan Huse, Orion Weiner, and Jason Cyster and my labmates in @huselab The Morgan Huse Laboratory, @OWeinerLab, and Cyster labs.

[Sneha Rao @sneha_arao]

‼️ Abstract deadline for BACS 2024 is this Friday April 12 ‼️

We highly encourage trainees at *all levels* to submit an abstract for a talk or poster. Come share your research with the awesome cytoskeleton community in the Bay Area!

[Sneha Rao @sneha_arao]

🎉 Super excited to announce that registration is now open for the 2024 Bay Area Cytoskeleton Symposium on May 13 at UC Berkeley! 🎉 Keynotes from Eva Nogales & @itsthewoolab, and trainee talks from selected abstracts!

Register now! https://t.co/47IxS5r5J5

[Henry De Belly @Henry_de_belly]

So hyped to see this great story by @DengkeMa lab being finally out!! This paper is full of fascinating data and I highly recommend a read:

Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin https://t.co/WUCEmldhiT

[Cell Biology J-Club @cell_club]

Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin | Science Advances https://t.co/SNuiBJFvAf

[Henry De Belly @Henry_de_belly]

My dear friend/collaborator Shannon is starting her lab at Stanford in a couple of months and she is looking to hire a postdoc to work with her on the mechanics of mitosis: https://t.co/zQFEBpZVCB

I cannot recommend Shannon enough, her lab is going to be super awesome!

[Weiner Lab @OWeinerLab]

Meet your new 2024 candidate at the Weiner lab CVRI happy hour! #Ivoted

[Weiner Lab @OWeinerLab]

This work is a great collaborative effort with the @HernanGGarcia and @BugajLab labs

[Weiner Lab @OWeinerLab]

Excited to share our paper on YAP dynamics and cell fate control! We reveal a concentration-dependent and temporal communication code for YAP that enables cells to choose between different downstream programs. Check it out!
https://t.co/Z0dRXcF5Rq

[Weiner Lab @OWeinerLab]

We are spinning in circles with excitement to see @JasonPTown fabulous work out @PLOSBiology ⤵️

[PLOS Biology @PLOSBiology]

.@JasonPTown & @OWeinerLab use spatially-defined #optogenetic control of a leading edge organizer to explore how #neutrophil-like cells balance “decisiveness” (needed to polarize in one direction) with flexibility (to respond to new cues) #PLOSBiology https://t.co/eQadr8UVN0