OrrLab

Orr Lab at WashU | PI: Miranda Orr, PhD | Lab Interests: Aging, Alzheimer's disease, Neurodegenerative disorders, Tau, and Senescence

[Alzheimer's Drug Discovery Foundation @TheADDF]

Congratulations to the 10 Goodes Prize winners who along with the ADDF have shaped the last decade of #Alzheimers research around the #biologyofaging, moving the field closer to treating the disease with #precisionmedicine. Hope is here. https://t.co/cw2a8jEe1m

[Bruker Spatial Biology @brukerspatial]

NanoString is excited to announce it will be acquired by Bruker Corporation in a $392.6 million agreement. We are grateful for our dedicated employees and customers! #futurelooksbright!

https://t.co/RjCNxJ0Don

[CTAD @CTADconference]

Thank you @TheADDF for bringing together at#ADPD2024 this impactful roundtable on Novel Approches in AD Research guided by the Biology of Aging with @MiiaKivipelto @jacques_touchon @a_hfillit Miranda Orr @WakeForest @DrJeffCummings

[Holger Heyn @hoheyn]

TO ALL #spatial #genomics CEOs!

Please read our Comment ⁦⁦@GENbio⁩

“Sounding an Alarm over Spatial Biology”

Scientists’ call for action. We are all part one community and have to act accordingly. Don’t let financial interests ruin innovation.
https://t.co/G95olbindZ

[Holger Heyn @hoheyn]

.⁦@nanostringtech⁩ is here to stay!

Joe Beechem speaks up ⁦@GENbio⁩:
“We are not going anywhere”.

Only #diversity will drive #innovation in Spatial Genomics!

#youarenotalone
https://t.co/bdP4rgidoC

[Arutha K @aruthak]

I'm curio-s, it may be time to parse on 10x?

[Bess Frost @bess_frost]

It has been fun working with @RCFNeuro, @alzassociation, @CurePSP and other organizers to develop the scientific program for #Tau2024! My lab will be there - will yours? March 25-26, 2024 in Washington, DC. Register now: https://t.co/5hvNHCx6ZU

[OrrLab @Orr_Lab]

Thrilled to help @jme_walker and her team explore differences in NFTs between #PART and #AD using GeoMx DSP! Awesome work! #nanostrung

[Bruker Spatial Biology @brukerspatial]

#Spatialproteomics reveal mechanisms of development and progression in #Alzheimer'sdisease. 🧠 👉https://t.co/RsNploZzAm

@Orr_lab from Wake Forest University used GeoMx DSP to show proteome differences at the basis of Aβ and p-tau distribution and pathogenicity.

#Fridayread

[Jamie Walker, MD, PhD @jme_walker]

Happy to share our latest publication - we used spatial proteomics to compare #PART and #AD looking at differences between NFTs, normal neurons and their microenvironments in the CA1 and CA2 subregions of the #hippocampus, as well as the entorhinal cortex. https://t.co/CaAj5oGgjp

[Wake Forest University School of Medicine @wakeforestmed]

🧟 The @Orr_Lab is researching senescent cells and their impact on memory problems. Could targeting "zombie" cells be a breakthrough in #Alzheimers treatments? Learn more: https://t.co/wL7FV97dJI

[Alzheimer's Drug Discovery Foundation @TheADDF]

ADDF-funded @Orr_Lab's #CombinationTherapy clinical trial on senescent cells supports the ADDF's core belief that the next generation of #Alzheimers drugs will be guided by #novel targets based on the #BiologyOfAging. More on the trial in @mcknightsltcn: https://t.co/LRwn4oBQqE

[Alzheimer's Drug Discovery Foundation @TheADDF]

Last week's 9th Annual Melvin R. Goodes Prize Luncheon & symposium reflected on recent breakthroughs in #Alzheimers research. This year, the ADDF honored DxA-funded scientist, Dr. Rhoda Au for her work with #DigitalBiomarkers and #diagnostics for early Alzheimer's detection.

[Nature Medicine @NatureMedicine]

First feasibility study of orally-delivered #senolytic therapy in #Alzheimersdisease reports favorable safety data and penetrance of #dasatinib into the brain with a modest impact on Alzheimer’s and aging biomarkers @wakeforestmed @MitziMGonzales @Orr_Lab
https://t.co/BdCefNthnA

[Wake Forest University School of Medicine @wakeforestmed]

Research from @Orr_Lab shows that treatment to clear #senescent cells in #Alzheimer’s disease is safe in Phase I clinical trial. Learn more about the study, which appears in @NatureMedicine. @TheADDF @nanostringtech  https://t.co/FHkbQ4AIDw

[Alzheimer's Drug Discovery Foundation @TheADDF]

Results from a new study led by ADDF-funded @Orr_Lab further validate that novel approaches to #Alzheimers centered around the biology of aging will guide the next generation of therapeutics. Read our statement on the senescent cell treatment study here: https://t.co/E00qeKkKrS

[OrrLab @Orr_Lab]

Exciting news! Led by @MitziGonzales, our team’s Phase I trial testing #senolytics in #Alzheimer’s disease reports on brain penetrance, safety, and biomarkers! 🧠 Phase 2 trial supported by @TheADDF is underway! #JoinOurStudy #SToMP-AD #Senescence #Aging https://t.co/vt88BIaUyZ

[OrrLab @Orr_Lab]

@The_CCAD alumni
@SusanneVanVeluw
@FannyElahi
@bucklr01 & mentors Randy Nixon & Alison Goate with @Orr_Lab #AAIC23 #CCAD

[Jamie Walker, MD, PhD @jme_walker]

A fun day 1 at #AAIC23 with @theREALaivisaur @bbonakda @MaggieFlanagan @Orr_Lab @JohnCraryMDPHD ☺️🧠🍨

[OrrLab @Orr_Lab]

@AdamsBioAging @americanaging @WakeForest Thanks so much for including me in your session, Peter! Looking forward to keeping in touch and sharing experiences with CosMx.

[Nathan Shock Centers @NathanShockCtrs]

Thank you to all who joined the NSC Directors Symposium at #AGE2023!
The session featured presentations from pilot grantees George Sutphin @senmorteco, Miranda Orr @Orr_Lab, Andrey Parkhitko, Anna @ThalackerMercer, Danielle Bruns, @SimoneSidoli, @MariaMMihaylova, & @CristalM_Hill