Structural & functional analysis revealed that the extracellular #chaperone#clusterin functions through two hydrophobic tails in preventing protein aggregation.
❕Publication: https://t.co/xSiIBf4yOI
❕Press Release: https://t.co/FYbyInLvy7
#Alzheimers@NatureSMB@PYusteCheca
Regulated proteolysis induces aberrant phase transition of biomolecular condensates into aggregates; a protective role for the chaperone Clusterin: https://t.co/2JPCJvvdq3
Very excited to share the structure and functional characterization of Clusterin, a key extracellular chaperone and apolipoprotein (ApoJ) linked to cancer, cardiovascular pathology and neurodegeneration. https://t.co/j2LToEP8nP
Scientists from the Hartl Department show that the protein #Urm1 protects other proteins in cellular stress situations by promoting phase separation.
❕Publication: https://t.co/75vmaNn3Mn
❕Press release: https://t.co/8KpfIQV6Ms
@CellPressNews
Escucha a José Manuel Moreno (catedrático y miembro @IPCC_CH ) : “Quitar carriles-bici es una ideología de fanáticos y lunáticos que van a causar muertes”. Así, sin pelos en la lengua hoy en el Congreso de los Diputados
I am delighted to announce that my PhD work has finally been published, in which we uncovered a novel role for GCN1 in mitigating translational readthrough.
#collision#readthrough#GCN1@MPI_Biochem
https://t.co/Or07AIOELo
A thread. 🧵 1/18
A team led by Ulrich Hartl found out that the protein GCN1 helps to secure the "accident site" after two #ribosomes collided and calls other complexes to degrade the defective #mRNA@CellCellPress
❕ press release https://t.co/opH43vAE0p
❕ full article https://t.co/L6WHmwPDwp
Dr. Paul Janssen, the founder of Janssen pharmaceutica (now J&J), was one of the most prolific drug discovery scientists ever. Between 1953-1991 Janssen and his team discovered >70 new medicines.
I enjoyed this paper about his R&D philosophy: https://t.co/lTCZjCO2l9
At ADPD 2023, scientists showed that biosensor cell lines that detect tau seeds do make tau fibrils. A chaperone tears them apart. Does this happen in the #alzheimersdisease brain? @adpdnet@UTSWNews@MPI_Biochem @MRC_LMB https://t.co/VI5fb3m10S
Join us for a PhD in the Protein Biogenesis lab @TheCrick ! We have a very exciting project aimed at understanding how human cells orchestrate the folding of different proteins at the ribosome. https://t.co/4OQIU1i0Qd
reflexiones tras asistir a oposición en @CSIC hoy:
o se cambia el procedimiento decimónico de captación de talento del @CSIC o el @CSIC está abocado a desaparecer. Eso de asumir que los candidatos tiene absoluta disponibilidad corresponde a la época de los toros de Guisando
We are recruiting! My lab @TheCrick is looking for a postdoc with #cryoEM expertise, to help us understand how the ribosome and chaperones collaborate to catalyze protein folding.
Check out our latest review about the diverse functions of the extracellular chaperone Clusterin in the pathogenesis of neurodegenerative diseases
https://t.co/JnBAPEA21q