PDAC Stromal Reprogramming Consortium

The NCI-funded Pancreatic Cancer Stromal Reprogramming Consortium (PSRC) is focused on improved understanding of the stroma & its interactions with cancer cells

[Anirban Maitra @Aiims1742]

Spatial determination and prognostic impact of the fibroblast transcriptome in #PancreaticCancer
https://t.co/QA0NLNz3eD
Tumor proximity determines state:
“Tumor proximal” - enriched in myCAFs, wnt ligands
“Tumor distant” - enriched in iCAFs, complement, wnt inhibitory signals

[Cancer Discovery @CD_AACR]

#ICYMI from the June issue—
In the Spotlight: #Pancreatic neoplasms are frighteningly common: A role for immune surveillance?
By Megan T. Hoffman and Stephanie K. Dougan.
https://t.co/ytKrrmQ8BI
@DanaFarber @DanaFarberNews @harvardmed

[Anirban Maitra @Aiims1742]

Out in @NatureComms from the @hopkinskimmel team:
A platform trial of neoadjuvant and adjuvant antitumor vaccination alone or in combination with PD-1 antagonist and CD137 agonist antibodies in patients with resectable #PancreaticCancer
@DrLizJaffee
https://t.co/3A0RkAGZqK

[AACR @AACR]

The pancreatic microenvironment may contribute to cancer onset and spread, according to research published in @CD_AACR and presented at #AACRras23. Learn more on the #AACRBlog: https://t.co/MxWogxhfXC @umichmedicine

[Anirban Maitra @Aiims1742]

From @Inserm @RemyNicolle et al in @NatureComms
Pacpaint: a histology-based deep learning model uncovers the extensive intratumor molecular heterogeneity of #PancreaticCancer
https://t.co/BphOs1cbt7
~40% of RNA defined “classical” cases harbor “basal-like” component on #AI

[Débora Vendramini-Costa, Ph.D @DebVendramini]

📢📢Spreading the word!!! Our Center, Henry Ford Pancreatic Cancer Center, is hiring a Grants manager!! If you are or know of someone who might be interested, please reach out!!!

https://t.co/paY5LRNlSY

[Teresa Zimmers @TeresaZimmers]

Featuring the opus that was @_sunnydae9's wide-ranging and outstanding dissertation work in #cancercachexia and #PancreaticCancer. Want to drive this project now? We are hiring! @OHSUKnight 🌉🛶🚠🚵‍♂️🗻🌊🧪🫂

[Marc Besselink @MarcBesselink]

Teaser #PREOPANC2 design & accrual: Total #Neoadjuvant #FOLFIRINOX in resectable + borderline resect #PancreaticCancer vs “winning arm” #PREOPANC trial #EAHPBA2023: accrual faster than planned ✅, final survival outcome expected in Sept 2023 ✅
@EmmelieDekker @BasGrootKoerkam @DPCG_official @DeltaplanA #alvleesklierkanker

[Cancer Discovery @CD_AACR]

From the June issue—
Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Pre-Neoplastic #Pancreatic Lesions, by @Pasca_Lab, @timofran1 et al.
https://t.co/6ZpTqAMdbU
@UMICHpancreas @UMRogelCancer @UMichSurgery #PanIN #PancreaticCancer

[AACR @AACR]

Submit an abstract by July 13 for the AACR Special Conference on Pancreatic Cancer (Sept 27-30, Boston), chaired by Christine A. Iacobuzio-Donahue, Anirban Maitra, Rosalie C. Sears, and Jen Jen Yeh.
https://t.co/gcqUCRNIU3
#AACRpan23 @ciacobu @Aiims1742 @SearsRosie @YehlabUNC

[Lyssiotis Lab @LyssiotisLab]

Hey Mom, I'm on the radio! This was a fun experience. Thanks to @KellyCutrara the opportunity to raise awareness for #PancreaticCancer and discuss our new study! cc: @UMRogelCancer, @UMICHpancreas, @UMPhysiology, @PanCAN
https://t.co/fOPEc5pciQ

[PDAC Stromal Reprogramming Consortium @PacmenC]

Letters of Intent for @CDMRP #PancreaticCancer Research Program are due in one month.
@PanCAN @arosenzweig19
https://t.co/7QB1bfy78V

[Anirban Maitra @Aiims1742]

The Visium spatial transcriptomics data of human and murine IPMN samples from our @CD_AACR paper is available at GEO for download at:
https://t.co/N2Zkw3e5I9
Hopefully will be useful to the #PancreaticCancer research community.
https://t.co/0bjQDTlZYa

[Lyssiotis Lab @LyssiotisLab]

New one in @CD_AACR from the @Aiims1742 Lab! Check it out!!

https://t.co/jDpSfPCc29

[Marta Sans Escofet @Marta_Sans_]

So happy to have our study now out in @CD_AACR!! We used #SpatialTranscriptomics and COMET imaging to spatially profile IPMN lesions of the #pancreas and identified NKX6-2 as a previously unknown transcription factor driving indolent gastric differentiation.

[Elizabeth McKenna @ElizSMcKenna]

Now online in @CD_AACR: #SpatialTranscriptomics of Intraductal Papillary Mucinous Neoplasms (#IPMN) of the Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential @Marta_Sans_ @Aiims1742 @MDAndersonNews https://t.co/BJBMFDkaSh

[AACR @AACR]

Submit an abstract by July 13 for the AACR Special Conference on Pancreatic Cancer (Sept 27-30, Boston), chaired by Christine A. Iacobuzio-Donahue, Anirban Maitra, Rosalie C. Sears, and Jen Jen Yeh.
https://t.co/8awcp4yDuN
#AACRpan23 @ciacobu @Aiims1742 @SearsRosie @YehlabUNC

[PDAC Stromal Reprogramming Consortium @PacmenC]

Fantastic keynote by @YatrikShahLab at @PacmenC consortium meeting on hypoxia, lipids and gases in cancer.
Thank you @Pasca_Lab @LyssiotisLab @timofran1 for inviting Dr. Shah for this meeting.

[Naim Rashid @naimurashid]

Excited to present our #PancreaticCancer stromal subtyping work at the @PacmenC meeting today in Ann Arbor Michigan with @YehlabUNC @itslaurapeng @isteaus! Had a lovely dinner last night with other U01 sites at @zingermans roadhouse. Big thanks to the organizers

[Jash Datta, MD @DrJashDatta]

🚨Our📜officially out in June issue of Cancer Discovery @CD_AACR @AACR! Thank you #DattaLab members esp @anna_bianchi22, mentor @NbmerchantMD, collaborators @BenStanger01 @EnedaToska @GabrilovichLab, sponsor @DrSDNimer & funders @PanCAN #PardeeFdn @AcademicSurgery @AmCollSurgeons