Paul Chammas

Postdoc in the Chromatin and Development lab at the @MRC_LMS. Tweets are 50% science, 50% randomness.

[The Tennis Letter @TheTennisLetter]

Hady Habib’s reaction after winning his 1st round at Australian Open

Imagine being the 1st from your country to qualify for a Slam

He did that 2 days ago

Imagine being the 1st from your country to win a Slam match

He did that today

For Lebanon 🇱🇧❤️

[Paul Chammas @Paul_Chammas]

@MoritzBauer_87 @MPercharde @MRC_LMS Thanks Mo!😁

[Paul Chammas @Paul_Chammas]

Happy to share our latest #preprint showcasing the work done during my postdoc in the lab of @MPercharde at the @MRC_LMS. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state. https://t.co/F40Vfn6KVR (1/8)

[Paul Chammas @Paul_Chammas]

@srishti_arya_17 Thanks Srishti! 😁

[Paul Chammas @Paul_Chammas]

@ekjot_k27 @MPercharde @MRC_LMS Thanks Ekjot!😁

[Paul Chammas @Paul_Chammas]

Tl;dr, MERVL is an integrator of multiple TFs to drive the 2C-like state, and drives some yet not all totipotency features. In contrast Dux-dependent toxicity is MERVL-independent and involves Noxa-induced apoptosis. Big thanks to all involved! @BryonyLeeke @Less_Sepulveda (8/8)

[Paul Chammas @Paul_Chammas]

Noxa KO in ESCs reduces Dux-dependent apoptosis and is even upregulated in the muscular dystrophy, FSHD, which is driven by DUX4 mis-expression. It’ll be interesting in future to look at therapeutic NOXA reduction in FSHD myoblasts. (7/8)

[Paul Chammas @Paul_Chammas]

@CesarSierraN @maradierssen @CRGenomica Congrats Cèsar!🥳

[Paul Chammas @Paul_Chammas]

@FerranGLl Congrats!🥳 enjoy your holidays😁

[Paul Chammas @Paul_Chammas]

@JuliaDiumenge @ALLOXbio @aj4re @pbcenturion @BenLehner Congrats Julia! 🥳 looking forward to see you all do amazing things!

[Dr Michelle Percharde @MPercharde]

Very excited to announce this 1 day symposium on 7th Dec @MRC_LMS: Stem Cell-Based Modeling of Reproduction & Development. Fantastic speaker line up and topics inc. implantation, diapause, infertility, maternal-fetal interactions & more. Pls RT!

Register:
https://t.co/4YQgDGpSuM

[Luciano Di Croce @ludicroce]

Still speechless! Past and current lab members came to Barcelona from all-over the globe for the 20th year anniversary of our lab at @CRGenomica @the_prbb !

[Paul Chammas @Paul_Chammas]

@Alexis_Barr @BethPennycook @Morales_Lucas_ so bad…

[Paul Chammas @Paul_Chammas]

@MPercharde @MRC_LMS 10/10 training, would recommend!

[Dr Michelle Percharde @MPercharde]

Quick break from leave for a lab coffee @MRC_LMS - the view alone makes it worth a visit! Also some lab training in baby handling 😉