The largest makers of vaccines have settled over $10 billion in criminal penalties over the past decade for falsifying data and lying to patients.
Every pharmaceutical product should be scrutinized.
An AI research uncovered over 300 new Nazca Lines.
Researchers have used artificial intelligence to uncover over 300 previously unknown geoglyphs in the Nazca Desert of southern Peru.
This recent finding, led by Masato Sakai from Yamagata University, nearly doubles the total number of known geoglyphs.
Marc Andreessen just dropped ~105 mins on Lenny's Podcast covering AI, jobs, careers, and why everyone is panicking about the wrong thing.
Just the clearest macro framework I've heard on where AI actually lands.
My notes:
𝟭. 𝗔𝗜 𝗶𝘀 𝗮𝗿𝗿𝗶𝘃𝗶𝗻𝗴 𝗮𝘁 𝘁𝗵𝗲 𝗲𝘅𝗮𝗰𝘁 𝗺𝗼𝗺𝗲𝗻𝘁 𝗵𝘂𝗺𝗮𝗻𝗶𝘁𝘆 𝗻𝗲𝗲𝗱𝘀 𝗶𝘁.
US productivity growth has been running at half the rate of the 1940-1970 era and a third the rate of 1870-1940. The global population is declining below replacement in dozens of countries, including China. Without AI, we would be panicking about economies shrinking from depopulation, not job loss.
The timing is almost miraculous. This is what Andreessen means when he says the real boom has not started yet. We have been in a 50-year productivity drought, and most people do not even realize it.
𝟮. 𝗔𝗜 𝗶𝘀 𝘁𝗵𝗲 𝗽𝗵𝗶𝗹𝗼𝘀𝗼𝗽𝗵𝗲𝗿'𝘀 𝘀𝘁𝗼𝗻𝗲.
Isaac Newton spent decades trying to transmute lead into gold and never succeeded. AI does something more powerful: it converts sand (silicon) into thought. The most common material in the world is the rarest output.
This one metaphor reframes the entire AI conversation. You do not have a job loss problem. You have a philosopher's stone sitting on your desk that you are not using enough.
𝟯. 𝗔𝗜 𝗺𝗮𝗸𝗲𝘀 𝗴𝗼𝗼𝗱 𝗽𝗲𝗼𝗽𝗹𝗲 𝘃𝗲𝗿𝘆 𝗴𝗼𝗼𝗱, 𝗮𝗻𝗱 𝘃𝗲𝗿𝘆 𝗴𝗼𝗼𝗱 𝗽𝗲𝗼𝗽𝗹𝗲 𝘀𝗽𝗲𝗰𝘁𝗮𝗰𝘂𝗹𝗮𝗿𝗹𝘆 𝗴𝗿𝗲𝗮𝘁.
The best coders right now are not reporting 2x productivity. They are reporting 10x. The gap between "pretty good with AI" and "elite with AI" is widening, not narrowing.
This is the most important signal for career planning right now. If you are just using AI to do the same job slightly faster, you are leaving the real leverage on the table.
𝟰. 𝗧𝗵𝗲𝗿𝗲'𝘀 𝗮 𝗠𝗲𝘅𝗶𝗰𝗮𝗻 𝘀𝘁𝗮𝗻𝗱𝗼𝗳𝗳 𝗯𝗲𝘁𝘄𝗲𝗲𝗻 𝗣𝗠𝘀, 𝗲𝗻𝗴𝗶𝗻𝗲𝗲𝗿𝘀, 𝗮𝗻𝗱 𝗱𝗲𝘀𝗶𝗴𝗻𝗲𝗿𝘀.
Every engineer now thinks they can be a PM and designer. Every PM thinks they can code and design. Every designer knows they can do both. And they are all correct, because AI enables each role to absorb the tasks of the other two.
I have seen this firsthand in the investing world. The analyst who can build models and write narratives is 5x more valuable than someone who can do only one. The same convergence is happening in the product.
𝟱. 𝗙𝗼𝗿𝗴𝗲𝘁 𝗧-𝘀𝗵𝗮𝗽𝗲𝗱. 𝗕𝘂𝗶𝗹𝗱 𝗮𝗻 𝗘-𝘀𝗵𝗮𝗽𝗲𝗱 𝗰𝗮𝗿𝗲𝗲𝗿.
Scott Adams could not have created Dilbert by being the world's best cartoonist or the world's best business mind. He needed both. The additive effect of two skills is more than double. Three skills are more than triple. Larry Summers puts it differently: don't be fungible.
The person who can code, design, and ship a product is no longer a unicorn. They are the new baseline for "extremely valuable." If you are only one of those three things, you are increasingly replaceable.
𝟲. 𝗝𝗼𝗯𝘀 𝗮𝗿𝗲 𝗯𝘂𝗻𝗱𝗹𝗲𝘀 𝗼𝗳 𝘁𝗮𝘀𝗸𝘀. 𝗧𝗮𝘀𝗸𝘀 𝗰𝗵𝗮𝗻𝗴𝗲. 𝗝𝗼𝗯𝘀 𝗽𝗲𝗿𝘀𝗶𝘀𝘁.
Executives never typed their own emails in the 1970s. Secretaries printed incoming emails and hand-delivered them. Both roles survived the transition, just with different task sets. The same will happen with AI and coding, PM work, and design.
Everyone obsessing over "will my job disappear" is asking the wrong question. The right question is: which tasks in my job are about to rotate, and am I ready to pick up the new ones?
𝟳. 𝗔𝗜 𝗰𝗼𝗱𝗶𝗻𝗴 𝗶𝘀 𝗷𝘂𝘀𝘁 𝘁𝗵𝗲 𝗻𝗲𝘅𝘁 𝗮𝗯𝘀𝘁𝗿𝗮𝗰𝘁𝗶𝗼𝗻 𝗹𝗮𝘆𝗲𝗿.
We went from human calculators to machine code to assembly to C to scripting languages. Each layer was dismissed by the previous generation. Each time, the new layer won, and total coding employment grew. AI coding is the same pattern, not a rupture.
The Perl programmers of 2005, laughing at JavaScript, are the C programmers of 1995, laughing at scripting. History rhymes, and it always rewards the people who adopt the next abstraction first.
𝟴. 𝗔𝗜 𝘁𝘂𝘁𝗼𝗿𝗶𝗻𝗴 𝗱𝗲𝗺𝗼𝗰𝗿𝗮𝘁𝗶𝘇𝗲𝘀 𝗲𝗹𝗶𝘁𝗲 𝗲𝗱𝘂𝗰𝗮𝘁𝗶𝗼𝗻.
One-on-one tutoring is the only method proven to move a student from the 50th to the 99th percentile (Bloom's two sigma effect). It used to require being born into royalty. Alexander the Great was tutored by Aristotle. Now, any kid with a phone can access the same quality of personalized instruction.
This is the most under-discussed consequence of AI. Every parent reading this should be supplementing their kid's education with structured AI tutoring right now. Not next year. Now.
𝟵. 𝗣𝗲𝘁𝗲𝗿 𝗧𝗵𝗶𝗲𝗹 𝘄𝗮𝘀 𝗺𝗼𝗿𝗲 𝗿𝗶𝗴𝗵𝘁 𝘁𝗵𝗮𝗻 𝗔𝗻𝗱𝗿𝗲𝗲𝘀𝘀𝗲𝗻 𝗼𝗿𝗶𝗴𝗶𝗻𝗮𝗹𝗹𝘆 𝗮𝗱𝗺𝗶𝘁𝘁𝗲𝗱.
Progress in bits masked stagnation in atoms. The built world is barely different from 50 years ago. Same bridges from the 1930s, same dams from the 1910s. Cartels, monopolies, unions, and regulations prevent the rate of change that people had 100 years ago.
This is also why AI will not transform everything overnight. Institutional sclerosis is real. Healthcare alone could take a generation. If you are building in atoms, budget for a war of attrition, not a blitzkrieg.
𝟭𝟬. 𝗠𝗼𝗮𝘁𝘀 𝗶𝗻 𝗔𝗜 𝗮𝗿𝗲 𝗴𝗲𝗻𝘂𝗶𝗻𝗲𝗹𝘆 𝘂𝗻𝗸𝗻𝗼𝘄𝗻.
Within a year of ChatGPT's launch, five American companies, five Chinese companies, and open-source all had roughly equivalent models. DeepSeek emerged from a hedge fund in China and basically replicated the American labs' work. The smartest AI insiders privately admit there aren't many real secrets among the big labs.
This is the most honest take I have heard from a top-tier VC. No one knows if the value accrues to models, apps, or infrastructure. Anyone who tells you otherwise is selling you certainty they do not have.
𝟭𝟭. 𝗔𝗜 𝗜𝗤 𝘄𝗶𝗹𝗹 𝗯𝗹𝗼𝘄 𝗽𝗮𝘀𝘁 𝗵𝘂𝗺𝗮𝗻 𝗹𝗶𝗺𝗶𝘁𝘀.
Human IQ caps around 160 because of biology. Current AI models test around 130-140. There is no theoretical ceiling stopping AI from reaching 200, 250, or 300. The concept of AGI as a "human equivalent" will be a footnote because AI will race past that threshold.
This is the frame that makes the "will AI take my job" debate feel small. We are not building a replacement for human thought. We are building something that will be better than the best human thought has ever been.
𝟭𝟮. 𝗧𝗵𝗲 𝗯𝗲𝘀𝘁 𝗳𝗼𝘂𝗻𝗱𝗲𝗿𝘀 𝗮𝗿𝗲 𝗿𝗲𝘁𝗵𝗶𝗻𝗸𝗶𝗻𝗴 𝘄𝗵𝗮𝘁 𝗮 𝗰𝗼𝗺𝗽𝗮𝗻𝘆 𝗲𝘃𝗲𝗻 𝗶𝘀.
Layer one: AI redefines products. Layer two: AI redefines jobs within companies. Layer three, which has not dropped yet: AI redefines the very concept of having a company. The holy grail is the one-person, billion-dollar outcome, and the best founders are chasing it.
Satoshi did it with Bitcoin. Instagram and WhatsApp came close with tiny teams. The question is no longer if this is possible with software. The question is how many of these we will see in the next five years.
AI is the philosopher's stone. The question is whether you pick it up.
The full podcast is worth your time. Link in replies.
Did you know that the death rate from measles declined by 98% BEFORE the measles vaccine was introduced?
“This is all on the CDC website… That decline had nothing to do with vaccines.”
So, if vaccines didn’t do it, what caused that decline from 1900 to 1963?
The answer is better nutrition, better sanitation, clean water, etc., according to Attorney Aaron Siri.
Yet “science” wants you to believe that vaccines saved the day.
But that’s not even the biggest vaccine deception. It’s what happens before they approve these shots for human use. 🧵
MIC DROP: RFK Jr. shuts down reporter's ridiculous appeal to authority. 🔥
Journalist: "You're a lawyer and an activist. You're not a doctor or a scientist."
RFK Jr: "Americans need to do their own research... there are experts on both sides saying the exact opposite of each other. Trusting the experts is a function of religion and totalitarianism... In democracy, we question everybody."
Doing 2 or more “exercise snacks” per day can boost VO₂ max by 5–17%.
VO₂ max, or maximal oxygen uptake, is one of the strongest predictors of longevity and overall health. Yet, nearly 40% of people who perform 150–300 minutes per week of moderate exercise fail to improve it. However, shifting intensity to vigorous efforts consistently elevates VO₂ max.
A recent meta-analysis found that short (5 minutes or less), moderate-to-vigorous efforts done throughout the day (2–10 times) improved aerobic fitness and muscular endurance in middle-aged and older adults.
These gains came with minimal time, just 5–65 minutes of total exercise per week (that's 3–5 times lower than current physical activity guidelines). However, body composition, strength, and blood lipids didn’t improve, likely requiring more training and/or dietary changes.
Even if you already work out regularly (and especially if you don’t), adding exercise snacks to your day may be a powerful, evidence-backed way to increase cardiorespiratory fitness and healthspan.
Bryan Johnson’s Best Health Hack Will Help You Sleep Better and Live Longer
“The single best thing I've learned out of everything I've ever done is (lowering) your resting heart rate before sleep is the best thing you can do for your health. Hands down.”
“Let's say it's 60 beats per minute. Your goal over the next month is to lower your heart rate by 10% or so. So if you're 60, be down at 54.”
“Here's how you're going to do it.”
1) No food for 4 hours before bed
2) No screens for 1 hour before bed
3) Amber and red lights in your house, no blues
4) No caffeine after 12pm
“The reason why your heart rate is so important is the lower your heart rate is, the better your sleep, the better your sleep, the better your willpower.”
“Did you know, if you don't sleep your prefrontal cortex goes offline and you lose your willpower?”
“So when you're trying to not eat the cookie, you're powerless. You can't do it. It's gone.”
“I promise you, this is the single best thing you can do for your health.”
@bryan_johnson
my favourite quote from atomic habits by James clear;
"It doesn't make sense to continue wanting
something if you're not willing to do what it takes to get it. If you don't want to live the lifestyle, then release yourself from the desire. To crave the result but not the process, is to guarantee disappointment"
Even though it may help people fall asleep faster and stay asleep, THC has several downsides when it comes to sleep.
For one, the sleep-promoting effects fade over time—it works for a few weeks but eventually stops being effective at the same dose. To keep sleeping better, you need to use more. THC also potently suppresses REM sleep, and when people stop using it, they can experience insomnia, a rebound in REM sleep, and even nightmares.
If you're looking for a sleep-promoting supplement, better options include (low-dose) melatonin, magnesium, glycine, L-theanine, and valerian.
16 years later…Trump & RFK Jr. are saying exactly what Jim Carrey & Jenny McCarthy were BLASTED for.
MCCARTHY: I don't know what happened in 1990? There was no plague that was killing children that we had to triple the amount of vaccines. Let's be smart!
CARREY: What happened after 1989 that warranted 26 more vaccines? Are all of them absolutely necessary?
MCCARTHY: Greed. Greed!
KING: Because they wanna make money.
MCCARTHY: Of course!
CARREY: It's twice as many as anywhere else in 30 countries in the Western world. We give twice as many shots as any of those countries. Why is that?
KING: Well, what are you against? Don't vaccinate for this, but vaccinate for that?
MCCARTHY: Yes!
CARREY: I think we have to choose which ones are absolutely necessary.
KING: How do I know which one?
MCCARTHY: You should educate yourself. We want to empower parents to educate themselves. Do we need to have the chickenpox? Do we need the hepatitis B shot on the second day of life?
CARREY: I don't think we can afford to assume that the people who are charged with our public health any longer have our best interests at heart all the time.
Parents have to make their own decisions, educated decisions. They have to look at the information.
MCCARTHY: Space out the vaccines...delay them till after one...clean out the toxins that are in them. We don't NEED that many.
KING: Why would a doctor not want to know more about something that could save a life or prevent a disease? I don't understand.
CARREY: Uhhh...the AAP is financed by the drug companies?? Uhhh...Medical schools are financed by the drug companies? This is a HUGE business. Vaccines are the largest growing division of the pharmaceutical industry. $13 billion.
MCCARTHY: They control medical schools!
CARREY: What we're asking is for them to take a loss for the good of our children. That's a tough sell in a boardroom.
McDonald’s invests $200 million to shift supply chain to more regenerative practices.
Soil Health and regenerative practices are a true win-win between MAHA advocates and large companies.
These moves should be celebrated.
This is a screenshot from American Academy of Pediatrics’ webpage, thanking the organization’s top corporate donors. These four companies make virtually every vaccine on the CDC recommended childhood vaccine schedule. AAP is angry that CDC has eliminated corporate influence in decisions over vaccine recommendations and returned CDC to gold-standard science and evidence-based medicine laser-focused on children’s health.
AAP today released its own list of corporate-friendly vaccine recommendations. The Trump Administration believes in free speech and AAP has a right to make its case to the American people. But AAP should follow the lead of HHS and disclose conflicts of interest, including its corporate entanglements and those of its journal—Pediatrics—so that Americans may ask whether the AAP’s recommendations reflect public health interest, or are, perhaps, just a pay-to-play scheme to promote commercial ambitions of AAP’s Big Pharma benefactors.
AAP should also be candid with doctors and hospitals that recommendations that diverge from the CDC’s official list are not shielded from liability under the 1986 Vaccine Injury Act.
More exciting results from a pilot study on creatine supplementation for Alzheimer's disease.
Participants who took 20 grams per day experienced a ~2 kg increase in handgrip strength and an increase in thigh muscle cross-sectional area after 8 weeks. That's without training.
These findings complement those of a prior publication showing higher brain creatine levels and improved cognition in the same participants.
Definitely an area of research to keep an eye on!