Philip J. Santangelo

Jonathan and Sheryl Layne Professor of Biomedical Eng. Wallace H. Coulter Department of Biomedical Engineering Emory Univ and Georgia Tech

[Philip J. Santangelo @PhilipJSantang1]

Cas13 has been proposed as an antiviral strategy. Our lab has been working towards making that a reality. Yesterday, in PLOS Pathogens, our newest paper on using Cas13 to treat influenza. @EmoryMedicine @UGAResearch @DukeMedSchool https://t.co/C65ggJ6f7h

[Philip J. Santangelo @PhilipJSantang1]

Are you interested in Cas13 as an anti-viral? I’m pleased to announce that our paper on the use of mRNA encoded Cas13 to treat Dengue infections in vivo was published today in Nature Microbiology. https://t.co/FBp3CaM1Be @DARPA @EmoryMedicine @CoulterBME @GeorgiaStateU

[Philip J. Santangelo @PhilipJSantang1]

A breath of fresh… medicine? Researchers are designing inhalable therapies for lung cancer, diabetes, measles, migraines and Covid-19. https://t.co/s2wMbwgnQz via @WSJ

[Philip J. Santangelo @PhilipJSantang1]

Very excited to see that our recent paper in Nature Materials was highlighted in a news and views article this month! Take a look! https://t.co/37oX96I2YQ @CoulterBME @ugavetmed @NatureMaterials @DARPA @GT_CHEM

[Philip J. Santangelo @PhilipJSantang1]

Have you seen the first issue of Nature Reviews Bioengineering? @natrevbioeng There is a a research highlight discussing our paper on inhalable mRNA formulations and therapeutics! https://t.co/4erED21EnN Please check it out! @DARPA @CoulterBME @EmoryMedicine @EmoryVaccineCtr

[Philip J. Santangelo @PhilipJSantang1]

@DrPlattLab @NIH @nibib @Morehouse @CoulterBME @GeorgiaTech @gatechengineers @GT_BioE @ibbgatech @BlackInBME @BlkInEngineerng Congratulations Manu! You will be missed.

[Philip J. Santangelo @PhilipJSantang1]

Healing Breath: Researchers Dramatically Improve Inhalable mRNA Therapy https://t.co/nyVxB0HPWS

[Philip J. Santangelo @PhilipJSantang1]

Any interest in mRNA lung delivery via nebulizer? In mice, hamsters, ferrets and non-human primates? Cas13-based therapeutics? Please see our newest paper @NatureMaterials, https://t.co/OL89zEGgMf. @DARPA @GT_CHEM @CoulterBME @msstate_vetmed @ULLafayette @ugavetmed @EmoryMedicine

[Philip J. Santangelo @PhilipJSantang1]

Also want to recognize @WellcomeLeap for their support.

[Philip J. Santangelo @PhilipJSantang1]

Just wanted to share our latest paper in Advanced Science on nebulized mRNA‐encoded antibodies against SARS‐CoV‐2. https://t.co/N50ow3tV54 @DARPA @DrJeffHogan @elafon10 @croweje @lab_haynes

[Philip J. Santangelo @PhilipJSantang1]

I just want to congratulate Jared Beyersdorf @EmoryMedicine on being selected a DARPA Riser @DARPA and presenting our recent work on nerve agent countermeasures @CoulterBME at the event on the GT campus https://t.co/zqGbYPUt7O. Great job Jared!

[Philip J. Santangelo @PhilipJSantang1]

Recent highlight of our work on non-viral, in vivo, gene activation. More to come!! https://t.co/XXXe0wYGg2

[Philip J. Santangelo @PhilipJSantang1]

I'd like to announce that our first paper on mRNA-encoded gene activation in vivo was published in ACS Nano. @acsnano Congrats and thanks to the Gersbach lab for this collaboration @cgersbach. @JohnDoench papers were very helpful. Support from @darpa. https://t.co/4gfWZB4O9r

[Philip J. Santangelo @PhilipJSantang1]

@aixsponsa @AldhiTR @jantungpiisang Cas13 only cuts RNA not DNA. We express it with mRNA so it is transient and not genotoxic. Not all CRISPR proteins are the same.

[Philip J. Santangelo @PhilipJSantang1]

Congratulations to all and great collaboration with James Dahlman and lab @DahlmanLab. Great work @MelissaPrasangi, Daryll V., Marine H. and Jared B., and all! @natBME, https://t.co/XRDxXi2s3D

[Philip J. Santangelo @PhilipJSantang1]

@UrnovFyodor My guess is that the problem was with delivery. I’ll comment more in the near future.

[Philip J. Santangelo @PhilipJSantang1]

Just want to let everyone know that our @CoulterBME @GeorgiaTech @EmoryUniversity @universityofga @GeorgiaStateU antiviral work published in Nature Biotech @NatureBiotech was highlighted in the NIH Director’s blog:
https://t.co/pu8sf27mGk

[Philip J. Santangelo @PhilipJSantang1]

Our work on Cas13 was recently highlighted in a Science article on antivirals. https://t.co/9liYHlyzk9
@NatureBiotech @CoulterBME

[Philip J. Santangelo @PhilipJSantang1]

I’m very happy to tell everyone about our new publication in Nature Biotechnology regarding a new mRNA encoded Cas13 therapy for influenza and SARS-CoV-2 demonstrated in rodent models. https://t.co/VMHlebOUQl

[Philip J. Santangelo @PhilipJSantang1]

@singareddynm @Peter_1_1 In this work we did not use LNPs but a polymer for delivery of RNA via a nebulizer. I'll comment more on lung delivery in future tweets!

[Philip J. Santangelo @PhilipJSantang1]

@hanniesarnie @DrPlattLab We are planning on moving to other species. Keep in mind that the hamster model for SARS-CoV-2 is a good model for severe disease. NHPs typically do not get as sick as the hamsters.