Stephen J. Tucker

Ion Channel Biophysics, K+ Channels, OXION PhD programme, @UniofOxford @OxfordPhysics @KavliOxford etc... Find me now on Bluesky....

[Stephen J. Tucker @ProfKalium]

https://t.co/8pFYgx2r3i

[RSC BMCS @RSC_BMCS]

Do not forget to submit an oral abstract for 8th RSC-BMCS / SCI Symposium on Ion Channels as Therapeutic Targets!

This symposium will showcase the most recent advances to aid the design of new ion channel therapeutics and promote interaction between scientists with a shared interest in the field of ion channel drug discovery. 🙌

Click here to submit an abstract 👇
https://t.co/wlqgLBC2iQ

🗓️Deadline: 15th November

#IonChannels25

[Stephen J. Tucker @ProfKalium]

Want to know when is a hydrophobic gate not a hydrophobic gate? Read more here in this Viewpoint:

https://t.co/sM0FUEuxqN

[bioRxiv Biophysics @biorxiv_biophys]

Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease https://t.co/Kc7l0IMxck #biorxiv_biophys

[Stephen J. Tucker @ProfKalium]

Our latest Preprint: More new CryoEM structures of TASK1 and TASK3 @K2pChannels including the G239R disease-causing mutant structure of TASK3 (KCNK9 Imprinting Syndrome/Birk Barel Syndrome)
https://t.co/Jv61F5Crku

[Stephen J. Tucker @ProfKalium]

https://t.co/Y1dAqJVaRM

[Stephen J. Tucker @ProfKalium]

I’m so glad at least one moment of this was captured for posterity. Fred is one of the true pioneers in the field and this was simply one of the most amazing talks I have heard.

[Claudia Moreno @Cladoni]

History of ion channels by one of his authors. Fred Sigworth’s closing seminar at the GRC was simply beautiful

[Baron Chanda @ChandaLab06]

One of the unforgettable moments at the 2024 Ion Channels GRC was the closing lecture by Fred Sigworth. If you missed it, here it is.. https://t.co/4I5lPTGnzr

[Stephen J. Tucker @ProfKalium]

https://t.co/dkI7cKlY9m

[Slav Bagriantsev @SlavBagria]

I feel hungry after just a few hours, but hibernating squirrels don't even after several months. This remarkable feat is possible due to reversible central hypothyroidism. A new study from the Gracheva lab by Sarah Mohr and @rafaeldaipra
https://t.co/irZURaxocr

[Stephen J. Tucker @ProfKalium]

Exciting times for @K2pChannels indeed!

[Dan Minor @ElectrosomeUCSF]

Structure of the human K2P13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site https://t.co/uOT46CHjBS
New work from our lab shows a hydrophilic gate (the flow restrictor) and polyunsaturated fatty acid site. See also work from @ProfKalium

[Stephen J. Tucker @ProfKalium]

Our latest Preprint on structure of THIK-1 K2P Channel - lots of new features including a lower 'Y-gate'.
https://t.co/bqU2BpVpaS
Also exciting that Dan Minor's group @ElectrosomeUCSF have almost identical results and some additional structures - also on @biorxiv_biophys

[Stephen J. Tucker @ProfKalium]

Structure of Kir7.1 https://t.co/dG5kF8xcC5

[Stephen J. Tucker @ProfKalium]

Our latest paper on Extracellular modulation of TREK2 K2P channels by nanobodies is now finally online in @NatureComms
https://t.co/P4HDlnvhpk

[Stephen J. Tucker @ProfKalium]

@wojciechkopec3 But do you know what a Desmond is?

[Stephen J. Tucker @ProfKalium]

"A fundamental mistake in receptor theory has led to an enduring misunderstanding of how to estimate the affinity and efficacy of an agonist."
https://t.co/6iqoKyZkax

[Stephen J. Tucker @ProfKalium]

@alexmsci @ColinNicholsLab Don't lend it to the students!

[Stephen J. Tucker @ProfKalium]

Matthew Freeman and Fran Ashcroft discuss "The Mould in Dr Florey's Coat" by Eric Lax in this #podcast

https://t.co/B3shk3rMko

[Dr. Sharona Gordon 🏳️‍🌈 🔬 @ProfSharona]

I am sad to report that Bill Catterall has died. He was an enormous presence @UW.