Do not forget to submit an oral abstract for 8th RSC-BMCS / SCI Symposium on Ion Channels as Therapeutic Targets!
This symposium will showcase the most recent advances to aid the design of new ion channel therapeutics and promote interaction between scientists with a shared interest in the field of ion channel drug discovery. 🙌
Click here to submit an abstract 👇
https://t.co/wlqgLBC2iQ
🗓️Deadline: 15th November
#IonChannels25
Our latest Preprint: More new CryoEM structures of TASK1 and TASK3 @K2pChannels including the G239R disease-causing mutant structure of TASK3 (KCNK9 Imprinting Syndrome/Birk Barel Syndrome)
https://t.co/Jv61F5Crku
I’m so glad at least one moment of this was captured for posterity. Fred is one of the true pioneers in the field and this was simply one of the most amazing talks I have heard.
One of the unforgettable moments at the 2024 Ion Channels GRC was the closing lecture by Fred Sigworth. If you missed it, here it is.. https://t.co/4I5lPTGnzr
I feel hungry after just a few hours, but hibernating squirrels don't even after several months. This remarkable feat is possible due to reversible central hypothyroidism. A new study from the Gracheva lab by Sarah Mohr and @rafaeldaipra
https://t.co/irZURaxocr
Structure of the human K2P13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site https://t.co/uOT46CHjBS
New work from our lab shows a hydrophilic gate (the flow restrictor) and polyunsaturated fatty acid site. See also work from @ProfKalium
Our latest Preprint on structure of THIK-1 K2P Channel - lots of new features including a lower 'Y-gate'.
https://t.co/bqU2BpVpaS
Also exciting that Dan Minor's group @ElectrosomeUCSF have almost identical results and some additional structures - also on @biorxiv_biophys
"A fundamental mistake in receptor theory has led to an enduring misunderstanding of how to estimate the affinity and efficacy of an agonist."
https://t.co/6iqoKyZkax