Proia Lab

Our own opinions 🔬👩🏻‍🔬🐭 👨‍🔬👩🏻‍💻📚#sphingolipids #metabolism #signaling #genetics #LysosomalStorageDisease #neurodegeneration #MouseModels

[JCI insight @JCI_insight]

Do microglia and/or neurons contribute to Gaucher disease? https://t.co/hWOpvmyGzD

Hannah Duffy, Colleen Byrnes, et al. use cell-specific deletion models to answer the question.

Image: specificity of the Gba deletion in microglia (left) and neurons (right).
@ProiaLab @NIDDKgov

[NIDDK @NIDDKgov]

In an NIDDK study, researchers created new mouse models for Gaucher disease, a rare genetic metabolic disorder, to study how it causes neuron degeneration in more severe forms of the disease. https://t.co/PErx5OrzHQ @JCI_insight

[Proia Lab @ProiaLab]

#NationalDNADay commemorates the completion of the Human Genome Project in 2003 and the discovery of the double-helical structure of DNA in 1953. 📸 #TheLadder @ NIH campus

[Proia Lab @ProiaLab]

Lipid structure matters in lysosomal storage disease https://t.co/fSMpZe38Nx

[The Lipid Chronicles @lipidchronicles]

Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1 Gangliosidosis https://t.co/LC4BKyJp2b (@jlipidres)

[Proia Lab @ProiaLab]

We also play music 😍 #MusicInTheAtrium

[Ilaria Del Gaudio @Idelgaudio90]

🔬#LRMSRC is an unmissable opportunity to discuss the biology of lysophospholipids.
Join us, share your research and learn from the world experts in the field @hlatim @ar_dilorenzo @ProiaLab @CChristoffer78
https://t.co/mnJG0Sg5vM
#Lysophospholipids #FASEBconferences

[Proia Lab @ProiaLab]

https://t.co/S4cdXlir9O

[Proia Lab @ProiaLab]

SARS-CoV-2 can harm the brain. Our study found ORF3a, a key protein of the virus, led to COVID-19 neuropathological features in mouse brains. ORF3a disrupted autophagy-lysosomal pathway & caused neuronal accumulation of factors linked to neurodegenerative disease. #sphingolipids

[Proia Lab @ProiaLab]

Childhood amyotrophic lateral sclerosis caused by
excess sphingolipid synthesis. Mutations disrupt the normal homeostatic regulation of serine palmitoyltransferase by ORMDLs. @NatureMedicine https://t.co/ByUEolmBDz

[Proia Lab @ProiaLab]

Seen on ⁦@NIH⁩ campus this morning. Watch out mice! #NIHFox

[Proia Lab @ProiaLab]

@IRPatNIH @NIDDKgov @NINDSnews

[Journal of Cell Biology @JCellBiol]

Congrats 👏 to Priyanka Narayan @narayan_pri for being selected to present “Discovering and reversing the metabolic consequences of APOE4 in iPSC-derived glia” at 12:50PM EDT #RUPneuro

[Nima Sharifi @NimaSharifiMD]

Robert Lefkowitz ⁦@the_asci⁩ and AAP talks about the old ⁦@NIH⁩ in the era of the Yellow Beret, circumstances of medical training that led to multiple Nobel prizes and what is different today.

[Proia Lab @ProiaLab]

Monocytes secrete signaling lipid S1P in lymph nodes to control the immune response
https://t.co/My3bDnijc2

[Proia Lab @ProiaLab]

Alzheimer's risk allele APOE4 disrupts intracellular lipid homeostasis in glia https://t.co/FAFwJArgnJ
Congrats @narayan_pri

[Rutter Lab @RutterLab]

Tonight on #MitoMonday, we briefly highlight the life and works of pioneering geneticist, living legend and authority on inborn errors of metabolism, Elizabeth F. Neufeld. #LateNightWithTheRutterLab

[Sphingolipid Biology @SL_Biology]

We are starting 2021 with a SphingoLeader talk by @ProiaLab! Don't miss this great talk!
Register at https://t.co/LNYmwiJY8I
to attend the live webinar and be elegible for an @AvantiLipids Coffee Break Giveaway!

#LipidTalks #Sphingolipids

[Proia Lab @ProiaLab]

Herbert Tabor (1918 – 2020) https://t.co/p5mGIOMJbL

[Proia Lab @ProiaLab]

Fascinating interview with Jesse Roth, former Scientific Director for intramural @NIDDKgov. Developed the concept of receptors for insulin and other peptide hormones.

[Journal of Clinical Investigation @jclinicalinvest]

.@UshmaNeill interviews Jesse Roth @NorthwellHealth in the latest episode of Conversations with Giants in Medicine: https://t.co/UmDOyETytw
Full video interview: https://t.co/PZrMhblquz

[Proia Lab @ProiaLab]

@pollyp1 @nyckevil Number 14: the great Howard Nash, NIMH/NIH