Do microglia and/or neurons contribute to Gaucher disease? https://t.co/hWOpvmyGzD
Hannah Duffy, Colleen Byrnes, et al. use cell-specific deletion models to answer the question.
Image: specificity of the Gba deletion in microglia (left) and neurons (right).
@ProiaLab@NIDDKgov
In an NIDDK study, researchers created new mouse models for Gaucher disease, a rare genetic metabolic disorder, to study how it causes neuron degeneration in more severe forms of the disease. https://t.co/PErx5OrzHQ @JCI_insight
#NationalDNADay commemorates the completion of the Human Genome Project in 2003 and the discovery of the double-helical structure of DNA in 1953. 📸 #TheLadder @ NIH campus
SARS-CoV-2 can harm the brain. Our study found ORF3a, a key protein of the virus, led to COVID-19 neuropathological features in mouse brains. ORF3a disrupted autophagy-lysosomal pathway & caused neuronal accumulation of factors linked to neurodegenerative disease. #sphingolipids
Childhood amyotrophic lateral sclerosis caused by
excess sphingolipid synthesis. Mutations disrupt the normal homeostatic regulation of serine palmitoyltransferase by ORMDLs. @NatureMedicine https://t.co/ByUEolmBDz
Congrats 👏 to Priyanka Narayan @narayan_pri for being selected to present “Discovering and reversing the metabolic consequences of APOE4 in iPSC-derived glia” at 12:50PM EDT #RUPneuro
Robert Lefkowitz @the_asci and AAP talks about the old @NIH in the era of the Yellow Beret, circumstances of medical training that led to multiple Nobel prizes and what is different today.
Tonight on #MitoMonday, we briefly highlight the life and works of pioneering geneticist, living legend and authority on inborn errors of metabolism, Elizabeth F. Neufeld. #LateNightWithTheRutterLab
We are starting 2021 with a SphingoLeader talk by @ProiaLab! Don't miss this great talk!
Register at https://t.co/LNYmwiJY8I
to attend the live webinar and be elegible for an @AvantiLipids Coffee Break Giveaway!
#LipidTalks#Sphingolipids
Fascinating interview with Jesse Roth, former Scientific Director for intramural @NIDDKgov. Developed the concept of receptors for insulin and other peptide hormones.
.@UshmaNeill interviews Jesse Roth @NorthwellHealth in the latest episode of Conversations with Giants in Medicine: https://t.co/UmDOyETytw
Full video interview: https://t.co/PZrMhblquz