Harriet Gee

#RadOnc @CPMCCwestmead, #PhysicianScientist, Clin A/Prof @sydney_uni. Adjunct Research Scientist @CMRI. #radbio of #SABR/#SBRT. Usual disclaimers.

[Harriet Gee @RadOncDoc_Gee]

@kristinasci @TheCesareLab @Eric73363938 @hildaApickett @szmyd_radoslaw @SiennaCasolin @AnnaGManjon @MelliW92 @Lea_Cavalli_ Thank you so much Kristina!

[Harriet Gee @RadOncDoc_Gee]

@gerryhanna @DrewMoghanaki @Mat_Guc @HenningWillers @_ShankarSiva @HegiFiona @TargetingCancer @brokendna @RogerRogergr @K_Butterworth @JacinthaOS @aislingbarryro @OOneill4 @lauremarignol Wonderful work Gerry from this amazing group of people....perhaps we can be honorary irish!

[Harriet Gee @RadOncDoc_Gee]

10/ ? clinical trials we can look at translational substudies @gerryhanna @DrewMoghanaki @Mat_Guc @HenningWillers @_ShankarSiva @HegiFiona. towards new biology of @TargetingCancer on the shoulders of key previous work including @brokendna @RogerRogergr

[Harriet Gee @RadOncDoc_Gee]

@TROGfightcancer @NatureCellBio Thank you so much!

[Harriet Gee @RadOncDoc_Gee]

9/ Hypothesis - all work in vitro so far lots of provisos - would be that tumours with HR defects would respond better to the combination of SBRT/SABR and immunotherapy.

[Harriet Gee @RadOncDoc_Gee]

8/ Brilliant team of scientists and collaborators @szmyd_radoslaw @SiennaCasolin, lucy french, @AnnaGManjon, @MelliW92, lea cavalli, Chris Nelson, Scott Page, @andrewdhawan @Eric73363938 @hildaApickett. Gratitude for friendship and science

[Harriet Gee @RadOncDoc_Gee]

7/ We are grateful for much support. This project was not possible without @CMRI_AUS , funding from NHMRC and ARC and longstanding support of the Western Sydney Local Health District Radiation Oncology Network. Our institutions including @Sydney_Uni

[Harriet Gee @RadOncDoc_Gee]

6/ This opens up new therapeutic opportunities to personalise the combination of SABR/SBRT and immunotherapy and run biomarker driven trials

[Harriet Gee @RadOncDoc_Gee]

5/ Conversely more error prone repair pathways lead to passage through mitosis with immune-stimulating DNA and RNA species

[Harriet Gee @RadOncDoc_Gee]

4/ Key take away for the rad onc community: timing and mode of cell death after ablative radiotherapy is dependent DNA repair pathway, with homologous recombination leading to mitotic 'non-immunogenic' cell death

[Harriet Gee @RadOncDoc_Gee]

2/ Wonderful summary of the science from @TheCesareLab @CMRI_AUS

[The Cesare Lab @TheCesareLab]

2/This work was led by out exceptionally talented post-doc @szmyd_radoslaw and co-supervised by @RadOncDoc_Gee. Long 🧵below with images and movies shared from the open access paper.

TL;DR double strand break repair determines the manner in which irradiated cells die.

[Harriet Gee @RadOncDoc_Gee]

@TheCesareLab @CMRI_AUS has a fabulous summary of the science - click through below

[The Cesare Lab @TheCesareLab]

2/This work was led by out exceptionally talented post-doc @szmyd_radoslaw and co-supervised by @RadOncDoc_Gee. Long 🧵below with images and movies shared from the open access paper.

TL;DR double strand break repair determines the manner in which irradiated cells die.

[Harriet Gee @RadOncDoc_Gee]

1/ Thrilled that our paper is out today in @NatureCellBio. A collaboration between WSLHD Radiation Oncology Network and @TheCesareLab led by @szmyd_radoslaw
https://t.co/kUeN0SpNqG

[Harriet Gee @RadOncDoc_Gee]

@rsamstein @ScienceMagazine @chirag_msk @MiriamSaffern @EricWil39327976 @HannaMOllila @diegochowell Congratulations, very interesting and important work!

[Harriet Gee @RadOncDoc_Gee]

@RogerRogergr @TheCesareLab @szmyd_radoslaw Thank you for your support!

[CMRI @CMRI_AUS]

@TheCesareLab @NatureCellBio Congratulations to our Genome Integrity Unit @szmyd_radoslaw and @RadOncDoc_Gee for this amazing advancement! We are so excited to see this help shape the future of cancer biology.

[Harriet Gee @RadOncDoc_Gee]

@DrewMoghanaki important study, thanks for posting and for commenting. one for you @lucindaburke

[Image X Institute @imagexinstitute]

We've got another Postdoc Research Associate position! Join us to advance lung function imaging during radiation therapy, reducing toxicity & improving immunotherapy access for lung cancer patients. https://t.co/938XBuLJW7 #LungCancer #Imaging #ResearchCareers

[Drew Moghanaki @DrewMoghanaki]

The largest randomized phase III trial evaluating lung SBRT publishes a secondary analysis of 30 patients with ultra central tumors. #radonc https://t.co/VTtynHgMlf

[RANZCR @RANZCRcollege]

There are a variety of funding opportunities available as part of the RANZCR Grants, Awards and Fellowships program.

Hear from Radiation Oncologist, Dr Kylie Jung.

Learn more and apply here:
https://t.co/2qUkRlttqo

#RANZCR #RadiationOncology