Rainer Nikolay

The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding in Nat. Comms. Read here:

[WilsonLab @WilsonLab2]

AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination | Nature Methods https://t.co/CBsyhmy3VH

[Rainer Nikolay @RainerNikolay]

Excited to share our new work on the proline-rich antimicrobial peptide Api137, which disrupts large ribosomal subunit assembly and induces RNA misfolding. Big thanks to the Spahn & Hoffmann groups for this amazing collaboration! https://t.co/c9QQif03x4

[Nature Communications @NatureComms]

Scientists from @Beck_Laboratory, @MPIbp, @EMBL, including @iskhusainov use #cryoET #teamtomo to compare the response of human gut and laboratory E. coli strains to the antibiotic tetracycline

https://t.co/MM74jkHCtQ

[Rainer Nikolay @RainerNikolay]

@SimoneReber @NatureComms Thanks Simone!

[Rainer Nikolay @RainerNikolay]

Read our latest #research on antimicrobial peptides that inhibit the activity of the bacterial ribosome in multiple ways, published in @NatureComms Thx to all co-authors & the members of the Grubmüller, Hoffmann and Spahn groups. https://t.co/7mKxsw91h1
https://t.co/dVrZMP6Ej5

[JacobsWagnerLab @JacobsWagnerLab]

Bacterial growth rate modulation is typically associated with genetic or environmental changes. In this preprint, we show that growth rate in Caulobacter varies between daughter cells in the same environment. Led by (brand-new) Dr. @skye_glenn. #ppGpp https://t.co/DFxbvs7AHh

[Akos T. Kovacs @EvolvedBiofilm]

Bacterial nucleoid is a riddle wrapped in a mystery inside an enigma

@JBacteriology Mini Review by Andrei Kuzminov

https://t.co/BdvFe6d0kA

[Rainer Nikolay @RainerNikolay]

@j_ortega_McGill @McGill_ACB @mcgillu @McGillSBMS @CRBSMcGill Was my pleasure to be part of the team.

[Lucy Dimitrova-Paternoga @DimitrovaLucy]

I am very glad to share our paper on 30S turnover!Thank you Helge and Daniel (@WilsonLab2 ) for letting me be part of that fantastic story! I would also use the occasion to thank the collaborators and reviewers for helping us shape this work!

https://t.co/lha8gKJTxJ

[Ben Engel @bengeliscious]

"Integrating cellular electron microscopy with multimodal data to explore biology across space and time"🔬👩‍💻🌌⏳ https://t.co/p6fkhe1eiH

Our new review is online @CellCellPress. Big thanks to our amazing co-authors @computingCaitie @svenklumpe @RommieAmaro @KukulskiWanda @EM_STP

[Yasuhiro Arimura @ArmrYshr]

Magnetic Isolation and Concentration (MagIC)-cryo-EM is a new method to enable direct structural analysis of targets captured on nanomagnetic beads, which requires only 0.0005 mg/mL of targets in 100 µL crude solution to make 10 cryo-EM grids. I will explain the magic behind it!

[ᐯIᑕTOᖇ ᑎIᘔET @victornizet]

Here is the original article on the “molecular de-extinction” of the antimicrobial peptides https://t.co/qNYopE6xCf

[Deuerling Lab @DeuerlingLab]

Check out our new study in @sciencemagazine. We show that NAC controls N-terminal methionine excision by MetAP1 in eukaryotes. Our results suggest a broader mechanism for how access of protein biogenesis factors to the translating ribosome is controlled.
https://t.co/PoLECOORJv

[Matthew L. Kraushar @MatthewKraushar]

check out our Spotlight Article @TrendsGenetics
🔥 hot 🔥 off the press!

teamed up with @OlivierDuss (@EMBLHeidelberg) & @RainerNikolay (@MPI_MolGen) to cover the recent mRNA decoding ribosome smFRET🤝cryoEM story from @TheBlanchardLab

open access 👇
https://t.co/fxq2IjTQdk

[Tarek @tarekh247]

Still not where we've been @PhysikFUBerlin but on a good way to get our Krios running after the relocation to #suprafab @FU_Berlin
Thanks for your patience to our users, keep fingers 🤞

[ISOP @protistologists]

Miniature RNAs are embedded in an exceptionally protein-rich mitoribosome via an elaborate assembly pathway | Matus Valach et al.
https://t.co/2cXI18kK84

[Rainer Nikolay @RainerNikolay]

This is a really cool tool! A generator almost as amazing as nature itself.

[Sidney Lisanza @sid_thesci_kid]

ARE YOU SICK OF AI?! BECAUSE WE DID IT AGAIN IN AN EVEN MORE OBSCURE SPACE THAN TEXT OR IMAGES. BUCKLE UP BECAUSE THIS WONT MAKE ANY SENSE UNLESS YOU LIKE PROTEINS 💃💃🧬🧵

[Mateusz Jaskolowski @matjaskol]

Dropping the anchor, how to TRAP a ribosome at the ER membrane!
Check out our new study describing a structure of TRAP complex interacting with the ribosome and Sec translocon published today in @NatureSMB
https://t.co/L7xw4Q3527

[ASM @ASMicrobiology]

It's time for #MicrobeoftheMonth! Who am I?

1) I’m a zoonotic pathogen.
2) I am nonmotile.
3) I have caused 3 DNA-verified pandemics during recorded history.

Think you know? Leave a guess below!

[WilsonLab @WilsonLab2]

Full Profiling of GE81112A, an Underexplored Tetrapeptide Antibiotic with Activity against Gram-Negative Pathogens - PubMed https://t.co/X0QeE7l3Tt