Riccomagno Lab

We are a lab @UCRiverside. We study neural circuit development and disease. We are particularly interested in Glial-Neuronal interactions.

[Riccomagno Lab @RiccomagnoL]

The final version of our study led by Wenny Wong and @jasonaestep in collaboration with @kevinmawright and @thejenjay investigating the role of Cas adaptor proteins and adhesion signaling during cortical glial scaffold development is now out @PLOSBiology https://t.co/nprQNm3ld6

[Alice Ting @aliceyting]

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time fluorescence to modulation of innate cell behavior (excitation or inhibition of neurons, induction of cell migration, etc.)?

Today we report in Nature a new technology platform that provides a step in that direction: PAGERs, for Programmable Antigen-gated G protein-coupled Engineered Receptors, convert recognition of extracellular soluble or cell-attached antigens into diverse user-selected responses. PAGERs are based on G-protein coupled receptors (GPCRs), which themselves are not structurally modular, but we were able to build in modular antigen gating by fusing an antagonist peptide to the extracellular N-terminal end, and then gating the antagonist with a fused antigen-binding nanobody.  When antigen binds, it sterically interferes with the antagonist, leading to relief of receptor inhibition. Drug or agonist can then turn on PAGER.

https://t.co/Clt8yjyk2y

[Mark Histed @HistedLab]

"Starting in the 80s, that investment in basic science began to pay off, driving a revolution in the molecular biology of cancer...

US gov't funding for science strengthens the economy in ways beyond cures."

I wrote today abt the case for science investment:

[Anandasankar Ray @Olfactozone]

UCR's Molecular, Cell & Systems Biology seeks Assistant Prof for July 2025. Seeking innovative scientists in cell/mol/dev biology to join a group of well-funded faculty with diverse research interests. Apply: https://t.co/l2CU4pIBv3 #AcademicJobs

[Sika @SikaZheng]

tenure track assistant professor position in RNA biology at UCR. https://t.co/qTuPFawqVY Come join the vibrant community! Please forward this opportunity to potential candidates! Thank you. @UcrRNAcenter @UCR_ScienceNews

[Vollum Institute @VollumInstitute]

The Vollum Institute is accepting applications for multiple faculty openings. We are interested in individuals whose research focuses on molecular and cellular neuroscience, genetics, neurodevelopment or signal transduction. #sciencejobs #neurotwitter
https://t.co/LnicYkonhZ

[Samantha Butler @Butlerlab_UCLA]

Please retweet! Last week to submit an abstract for @CSHL meeting "Molecular Mechanisms of Neuronal Connectivity", new deadline July 10th. It's a great line up of keynote speakers, with lots of opportunities to give a short talk! @dacolon @CathyFlyMom https://t.co/XyUiRBGTtN

[Riccomagno Lab @RiccomagnoL]

@krissylyon Congratulations!

[Richard Sever @cshperspectives]

This was always a hope - related to why we make QR codes for preprints (so authors can put them on posters).

[Tim Mosca (he/him) @drosophilosophy]

APPLICATIONS ARE DUE THIS FRIDAY!!
it has been a thrill of my life to teach this course. some come join us for another amazing summer at @CSHL ! the @CSHLflycourse is the premier way to learn the state-of-the-art in development, physiology, and behavior! https://t.co/3HQovvLMsg

[Anandasankar Ray @Olfactozone]

New paper out from my lab, a totally new chapter in our work with volatile odorants! How long-term exposure can alter chromatin and gene expression via HDA inhibition.

[Karine Le Roch @KarineLeRoch1]

We are recruiting an Assistant Professor in Computational Biology. The position description and link can be found at : https://t.co/QbCfSBKAWm (https://t.co/QbCfSBKAWm)

[The Chaturvedi Lab @Chaturvedi_Lab]

I am thrilled to announce that I will joining @UCRiverside as an assistant professor in mammalian virology starting January 1! The Chaturvedi lab will decode fate-dictating circuits in viruses to design next-generation medicine! Hiring at all levels,RTs are appreciated! @UCRCNAS

[Elena Blanco-Suárez @westboundsigned]

Excited to present our first paper! 🥳 Congrats to all authors (VERY proud of them and their hard work💪🏽). Here we show that the chordin-like 1 (Chrdl1) KO mice 🐭recover motor function faster after ischemic stroke. Keep reading the🧵1/4
https://t.co/EFS3J63h73

[Britta Engelhardt @Britta_in_Bern]

Exciting work from the Betsholtz lab to which we were allowed to contribute a little. A MUST READ for researchers investigating the meninges. Molecular anatomy of adult mouse leptomeninges https://t.co/k6N9ZkwYjv

[Science Magazine @ScienceMagazine]

AlphaMissense, a tool by DeepMind, can help researchers learn more about the effects that missense mutations have on disease, and could help identify previously unknown disease-causing genes, according to a new Science study.

Learn more: https://t.co/GzKVdnUS5I

[Riccomagno Lab @RiccomagnoL]

A very interesting take

[Drug Monkey @drugmonkeyblog]

Call Your NIH Program Officer https://t.co/wxze2vFFNW via @drugmonkeyblog

[Duke Department of Cell Biology @DukeCellBiology]

📢 Exciting opportunity! 🎉 Joint Faculty Search between Duke Departments of Cell Biology 🧫 and Biostatistics & Bioinformatics 📊 is NOW OPEN! Seeking innovative faculty developing & applying Deep Learning/AI 🖥️🧠 in biological sciences. Apply today! 👇⬇️
https://t.co/aIhxSOn6Lk

[Riccomagno Lab @RiccomagnoL]

Great team effort by Alyssa Treptow @nealoofar @TeresaUbina

[Riccomagno Lab @RiccomagnoL]

The final version of our study led by Wenny Wong and @jasonaestep in collaboration with @kevinmawright and @thejenjay investigating the role of Cas adaptor proteins and adhesion signaling during cortical glial scaffold development is now out @PLOSBiology https://t.co/nprQNm3ld6

[Jeremy Kay @jnk_lab]

Now published @Dev_Cell – How do neurons avoid connecting to the wrong synaptic partners? @cameronprigge and a awesome team of collaborators worked out a new mechanism which I long-form tweeted about last fall 👇 So excited to see this published!