Richard Knight

First in the world to perform laparoscopic radical prostatectomy using FlexDex platform. Prior USAF. Urologist in Binghamton, NY and Norfolk, UK. Views my own.

[QianJanieQin @QianJanieQin]

PRACTICE CHANGING: #KEYNOTEB15/EV304- in #MIBC, periop EV/P led to sig EFS (NR v 48.5m, 24m EFS 79.4 v 66.2%, HR0.53; 0.41-0.7), OS (NR v NR, 24m estimated OS 86.9 v 81.3%, HR 0.65; 0.48-0.89), pCR  (55.8 v 32.5%) benefit v. neoadj gem/cis, supporting EV/P as SOC in this setting

[Katy Beckermann @katy_beckermann]

Cochrane updated its PSA screening meta-analysis. 789,086 men across 6 RCTs.

➡️ PCa-specific mortality: rate ratio 0.87 (moderate certainty)

➡️ Metastatic diagnosis: RR 0.65

➡️ Adverse events / QoL: little to no difference

Why this matters: 💡 PSA screening is back on stronger evidentiary footing for disease-specific mortality. Shared decision making still drives the recommendation downstream and additional tools (biomarkers and MRI) continue to improve the gap.

https://t.co/VZk9tKRW0V

@EBMUrology #ProstateCA #Screening #Cochrane #GUonc #AUA26

[Katy Beckermann @katy_beckermann]

PSA nadir at 24 weeks remains one of the strongest prognostic signals mHSPC, but the meaning depends entirely on metastatic volume.

➡️ Pooled analysis of 5 STAMPEDE phase 3 trials (n=7,129)

➡️ With abi±enza + PSA ≤0.2 ng/mL at 24 wks: 96-mo OS was 64% in low-volume mets vs 45% in high-volume

➡️ Non-metastatic, node-positive: 79% 96-mo OS

Could PSA nadir + volumetric burden refine clinical-trial enrichment for treatment intensification? 🩺

https://t.co/LKtWJLGdHq
#ProstateCA #mHSPC #GUonc

[UroToday.com @urotoday]

Study examines the path to proficiency in prostate MRI interpretation for trainees. @ddeniffel @TU_Muenchen & @trwherrmann join @zklaassen_md @GACancerCenter to discuss learning benchmarks for prostate MRI interpretation from 14 MRI-naive trainees reading 200 multiparametric MRI cases. #WatchNow > https://t.co/qaLD9DIOus

[MUSC Urologic Oncology Program @MUSC_UroOnc]

No antibiotics for transperineal prostate biopsy? 🤔

Multi-institutional cohort (n=904):

• UTI rate: 2.0% — no difference with vs without antibiotics
• Urosepsis: rare (0.2%), only in antibiotic group
• AUR: 4.9%, linked to larger prostate size

👉 Antibiotics may not be necessary for TPB

Congrats to @MatveyTsivian and Rob Smith for this contribution.

🔗: https://t.co/82VVZH4X9v

@EMW2000 @MatveyTsivian @JayChavaliMD @JL_Drerup @SES_AUA @UroOnc @SUO_YUO @GenevaMaeP @LuisMedinaMD

[Jim Hu @jimhumd]

@MUSC_UroOnc https://t.co/wFVO1D3T9N

[World Health Organization (WHO) @WHO]

Wellness is active, not passive. It's the choices we make today, and every day that shape our health. On this International Wellness Day, what choice will you make?

[NEJM @NEJM]

Original Article: Perioperative Enfortumab Vedotin and Pembrolizumab in Bladder Cancer (phase 3 KEYNOTE-905 trial) https://t.co/liPEVlPfHV

Editorial: Enfortumab Vedotin plus Pembrolizumab as Perioperative Therapy https://t.co/wIH8w21yJg

#Oncology

[UroToday.com @urotoday]

Examining guidelines on radiotherapy for #BladderCancer with carcinoma in situ. @ConstanceHuck joins @UroDocAsh to examine whether carcinoma in situ should contraindicate trimodality therapy for muscle-invasive bladder cancer. The conversation highlights how historical data showing poor outcomes with CIS may be outdated, as older studies used split-course radiotherapy and inferior imaging techniques. #WatchNow on UroToday to learn more > https://t.co/FzLuRTa5ik

[Jesus Freakin Congress @TheJFreakinC]

🚨ICE/Border Patrol agents were caught on camera committing a hit-and-run in Minneapolis.

In the video, an unmarked federal vehicle is stopped in the road. A legal observer is sitting in a car behind them, not violating the law, just observing.

Then, without warning, the agents start reversing the vehicle towards the observer…

But, they failed to notice a parked car sits directly behind them.

As the observer backs up, the federal vehicle slams into the parked car.

They stop… and pull forward.

You can see the moment they realized they just fucked up, and are debating what to do.

They realize no one is in it… so they drive away.

And this isn’t the first time…

ICE and Border Patrol agents are driving aggressively through communities across the country, using their vehicles as weapons, putting neighbors, families, and bystanders at risk.

And anytime they hit someone, instead of a parked car, they aggressively arrest the person they hit and say they were “rammed.”

For a department that constantly claims it’s hunting criminals, their agents sure seem to be the ones committing the crimes.

[Brian’s Breaking News and Intel @intelFromBrian]

#BREAKING

ICE just shot and killed someone again. In Minneapolis.

5 shots. In front of Glam Doll Donuts

[Ryan Grim @ryangrim]

Drop Site obtained harrowing footage of the latest killing which appears to be from the perspective of the woman in pink filming from the sidewalk

[Richard Knight @RichardBKnight]

Looking forward to #SGSU26 with this outstanding urologist and friend, Dr. Matthew Kasprenski.
@HiltonHotels
@LongBeachCity
@govurology
@whaler170mk

[Richard Knight @RichardBKnight]

1st OptiLume @NYUHSINC

@LABORIEMEDICAL

[Society of Government Service Urologists @govurology]

Countdown to Long Beach for Kimbrough Urological Meeting! All Urologists and Urology Professionals are invited to attend. Program approved for 18.75 CME.
see program https://t.co/bvCUiMCNgE
#sgsu26

[Adam B. Weiner, MD @Adam_Weiner535]

🚨23 years of PSA screening in @NEJM 🚨

👉ERSPC RCT of >162k patients

📅Median 23 year f/u PSA screening lead to...

📉 #prostatecancer mortality by 13%

✅1 death prevented for every 456 men invited for screening or 12 diagnosed w/ PCa

📉Risk of advanced PCa by 34%

⭐️Benefit continues to rise over time as harm-benefit ratio improves

🔗https://t.co/hGCAfGpmhE

@PCF_Science @PCFnews @urotoday @UrologyTimes @renalandurology @UroOnc

[Richard Knight @RichardBKnight]

Love is stronger than hate. Love is love.

@NYUHSINC

[Richard Knight @RichardBKnight]

Thank you Ms. Sarah Wood for organizing a wonderful @BAUSurology East of England Urology meeting @IWMDuxford

It was a great way to end my three years working @NNUH and @JamesPagetNHS

[Richard Knight @RichardBKnight]

Farewell and see you later!

Thank you so much for an amazing three years!

@NNUH

[Andrew Vickers @VickersBiostats]

Infection rates were significantly lower in TP vs. TR at 7 days (p=0.033) and 35 days (p=0.034), tho' not 4 months (p=0.1). Not sure why this is being reported as "negative" for infection https://t.co/6S1F4SfSeh