Rout Lab

Lab of Michael Rout @RockefellerUniv | NCDIR member (@IntActOme) | Interactomics, NPCs, nuclear transport & making nanobodies

[Rout Lab @RoutLab_RU]

Incredibly excited to share this paper with the community! Congratulations authors including @DrMartyTaylor, @dfhoyosg, @ArthurZalevsky, the amazing team at @rome_tx led by Donna Romero, @macro_momo, @bengrbm, Eddy Arnold @RutgersU, Matthias Götte @UAlberta, & @KathleenHBurns

[Trevor Van Eeuwen @_themovingvan_]

So excited to share our story revealing structures, functions and adaptations of the human LINE-1 retrotransposon, an ancient genetic parasite that has written 1/3 of the human genome and is implicated in cancer, aging, & autoimmunity. Now out in @Nature https://t.co/wyo0fTUn4e

[Rout Lab @RoutLab_RU]

@RockefellerUniv And again thank you to all wonderful authors for getting this paper over the finish line. Incredibly happy with how it turned out!

[Rout Lab @RoutLab_RU]

You thought it was gone but it's back! Incredibly happy to have this story out now at @NatureCellBio: https://t.co/HDTp5JG256

[Rout Lab @RoutLab_RU]

Don't spend restless nights worrying about the dynamics of nuclear transport. Read our latest review and rest easy!

https://t.co/7pqx5KUNjd

[Rout Lab @RoutLab_RU]

Also thank you @RockefellerUniv for this wonderful profile! https://t.co/ZiMPOaOGU4

[Barak Raveh @BarakRaveh]

This was a true team effort across HUJI, UCSF/QBI, Rockefeller, Einstein, Basel, and UCSD/HHMI. Immense thanks to our colleagues and collaborators. @salilab_ucsf @RoutLab_RU, @DavidCowburn1 , @TheVillaLab (special shoutout to @dgvjayS), and the Lim lab.

[Rockefeller University @RockefellerUniv]

A new @PNASNews study from @RoutLab_RU, working with a team led by the Hebrew University of Jerusalem, solves the long-standing mystery of how NPCs make split-second decisions about which molecules to allow to pass through their molecular gates: https://t.co/dhcSJEzijE

[Rout Lab @RoutLab_RU]

And highlights from @RockefellerUniv https://t.co/npiIJ1FYAe and @physorg_com https://t.co/qfaxfWrdeX

[Rout Lab @RoutLab_RU]

Nuclear Pore Complexes (NPCs) are the gateways to the nucleus, but how can they be both rapid and picky, even for very large cargoes? To answer this question, we built the most detailed data-driven model to date of transport through NPCs.
https://t.co/DWh3XMWZPL

[Rout Lab @RoutLab_RU]

Congratulations all authors, particularly @dgvjayS @neeleshsoni03 @JoshHutchings94 who led this heroic effort on the first molecular model of the NPC nuclear basket. Out now in @CellCellPress

[Digvijay Singh @dgvjayS]

Our work on the architecture and model of the #NuclearBasket is now out @CellCellPress. https://t.co/OmHf7ECJns.  @HHMINews, @IntActOme #NPC #teamtomo
A short tweetorial follows

[Rout Lab @RoutLab_RU]

Amazing! Congrats Steve

[Steve L. Bonilla @Steve_Bonilla]

Excited to share our short review on the challenges of applying single-particle cryo-EM to RNA structures and some of the methods developed to overcome them. Hope you find it useful! https://t.co/Hggg3CX7Ak

[Neelesh Soni @neeleshsoni03]

From preprint to journal. Our nuclear gatekeepers have successfully unlocked the gates to Cell (Journal) https://t.co/ZA1xVgZtCD #NPC #integrativemodeling Congrats to team @dgvjayS @JoshHutchings94 @ig_ech @RoutLab_RU @salilab_ucsf @TheVillaLab Animation https://t.co/Av7fD7Yfs0

[Rout Lab @RoutLab_RU]

👀👀👀

[Beck Laboratory @Beck_Laboratory]

In a great collaboration with @HummerLab and the Kräusslich lab, @jpkreysing, @MaziarHeidari1, @VojtechZila and others tackle what happens when HIV capsid goes through an NPC. Instead of the NPC cracking the capsid, the capsid appears to crack the NPC (@MPIbp @CiidHeidelberg).

[Beck Laboratory @Beck_Laboratory]

In a great collaboration with @HummerLab and the Kräusslich lab, @jpkreysing, @MaziarHeidari1, @VojtechZila and others tackle what happens when HIV capsid goes through an NPC. Instead of the NPC cracking the capsid, the capsid appears to crack the NPC (@MPIbp @CiidHeidelberg).

[Rout Lab @RoutLab_RU]

Wow! @TheVillaLab @dgvjayS @salilab_ucsf

[Membrane Protein PDB @MemProtPDB]

The Molecular Architecture of the Nuclear Basket | bioRxiv
https://t.co/KJrFvE6ThJ

[Elizabeth Villa @TheVillaLab]

It cannot be done, they said.. It's too flexible, they said.. 😁
https://t.co/6wDKmXeXfL #NPC #teamtomo #integrativemodeling by @dgvjayS @neeleshsoni03 @JoshHutchings94 @ig_ech et al. Great collaboration w/ Qiang Guo, Brian Chait, Javi Fernandez-Mtnz, @RoutLab_RU @salilab_ucsf

[Rockefeller University @RockefellerUniv]

Rockefeller's @SanfordMSimon featured in @guardian for his work on fibrolamellar carcinoma, a rare liver cancer:

“The moment I learned of Elana’s condition is seared into my memory. I was determined to find out what caused it and find ways to counter it."
https://t.co/q4IFtmHtYN

[Rout Lab @RoutLab_RU]

👀👀👀

[Beck Laboratory @Beck_Laboratory]

Collaborative work led by @svenklumpe resolves the structure of a mobile genetic element inside of developing tissue. Together with @juliusbrennecke @BriggsGroup and the fabulous Jürgen M Plitzko. #cryoET
https://t.co/FfkkENtGeP

[Patrick Lusk @Plusk4u]

Dynamin-like proteins at the nuclear envelope? That and other surprises in excellent work by @PhilipMannino1 with help from @NicholasAder @TJ_MeliaLab and @LuskingL! #autophagy

https://t.co/YsUimhTyby

[Rockefeller University @RockefellerUniv]

Postdocs! Apply now for the Exceptional Scholars Workshop, a program for mentorship of postdoctoral fellows from underrepresented or disadvantaged groups as they enter prepare for the faculty search and interview process. More info here: https://t.co/3nHkri4XAO

[Journal of Cell Biology @JCellBiol]

.@udi_yael et al. @RoutLab_RU present a new method for quantitative subcellular fractionation of a wide range of mammalian cells while maintaining nuclear integrity. https://t.co/Bla38XXqCb

In our Tools collection: https://t.co/ts47w4aXuJ

[Gael Cristofari @retrogenomics]

First paper: https://t.co/qzymdVWVRg
by @DrMartyTaylor @macro_momo @rome_tx @bengrbm @RoutLab_RU @KathleenHBurns and many others not on X.