So excited to share our story revealing structures, functions and adaptations of the human LINE-1 retrotransposon, an ancient genetic parasite that has written 1/3 of the human genome and is implicated in cancer, aging, & autoimmunity. Now out in @Nature https://t.co/wyo0fTUn4e
Excited to share our new @ScienceMagazine paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
https://t.co/438Ub1N2ry
Thrilled to share our work with the Ben Black Lab, led by a co-mentored star MD/PhD student Katie Kixmoeller (@PennMedicine,@BMBGGUPENN,@BB_UPenn), now in @CellCellPress! We used cryo-ET to study kinetochore features in human mitotic chromosomes. 🧬🔬❄️
https://t.co/4yR1CrGybM
Congrats @TriggerLoop and @PennMurakamiLab on transcription start site scanning and contributions from everyone’s favorite general transcription factor TFIIH https://t.co/0lCF2VpkoS
We tracked a pandemic decimating beetle colonies and used cryoEM for sequencing-free discovery of the new virus that caused it. This virus is crazy; parvoviruses aren't supposed to have such structured protein-DNA interactions. We fulfilled all 4 of Koch's postulates for etiology
Can't believe I get to say this, BUT...just started as an assistant professor @BiophysicsJHMed@HopkinsMedicine! So excited to work with all of my new colleagues in the Hopkins Biophysics community!
It's finally happened. Integrative structures are now in the PDB archive! https://t.co/86MDAqL6BA
Check out the structures on the PDB-Dev website https://t.co/T55Iyvkezz and in the main archive https://t.co/Jr2MlocnrZ
Congrats to the team, especially @brinda_vallat!
Our work on the architecture and model of the #NuclearBasket is now out @CellCellPress. https://t.co/OmHf7ECJns. @HHMINews, @IntActOme #NPC#teamtomo
A short tweetorial follows
Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells!
https://t.co/ScWOAQRjTw
Humbly sharing my first author paper, Structure of Hir histone chaperone complex. (yeast version of HIRA) Collaborative work from Murakami Lab, @MarmorsteinLab, @GarciaLabMS, @TriggerLoop and thanks for @bradyajohnston's MolecularNode. https://t.co/Ref5ekFtZS open access.
I am thrilled to see my first postdoc paper published in @NatureSMB! 🌟🧠🧬
“Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease”
https://t.co/cJenBgokfl
1/n 🧵