My latest paper with @sohallab describes a novel long-range inhibitory (GABAergic) circuit in the mouse brain that allows the prefrontal cortex to exert top-down control on hippocampal activity during exploratory behavior.
Link: https://t.co/e9eIRMOhma
Summary 🧵 below...(1/6)
New paper from the lab out today! @jeremy_biane, @max_ladow and team describe how neural population dynamics in dorsal and ventral CA1 evolve with associative learning and outcome expectation. Full text here: https://t.co/lSMxx8zRGU
great to see this out! expertly crafted by @DaveKoop highlighting work from @mejoffe@Ruchimk@candelabellot and kirstie, hugo and hector who i dont have twitter handles for! PFC interneurons are cool! (esp when connected to hippocampus) https://t.co/ayS38jRaPO
During navigation, landmarks are encoded not in single cells but in the collective hippocampal population dynamics. Excited to be part of this work with @anagelhus Sebastian O. Andersson @soledad_gcogno@MayBrittMoser@KISNeuro#KiloNeurons#Neuropixels
https://t.co/cWPUgQQEIy
Excited to see our paper on Unsupervised discovery of brain states in Hide and Seek out today on @CurrentBiology ! A massive exploration effort done by Bence Bagi @bagibence during his masters at @HumboldtUni in the @BrechtLab. That continued through years of pandemic.
@thomasjpace Thanks Thomas! We have not explored this, but it would be really interesting if similar inhib circuits exist for vis attn. One related study that comes to mind shows frontal long-range excit circuits recruiting local inhib for top-down control of vis actv
https://t.co/nnQ0ZdVYD2
My latest paper with @sohallab describes a novel long-range inhibitory (GABAergic) circuit in the mouse brain that allows the prefrontal cortex to exert top-down control on hippocampal activity during exploratory behavior.
Link: https://t.co/e9eIRMOhma
Summary 🧵 below...(1/6)
@vishnusreekr Thanks Vishnu! I made the illustrations in Adobe illustrator and used https://t.co/Yn7zUCkeTu to create GIFs.
Detailed instructions in this blog — https://t.co/Nj2VNjqPL0
In conclusion: our study describes a novel anatomical pathway that allows the prefrontal cortex to alter information encoding and network activity in the hippocampus, thereby exerting top-down control over exploratory behavior. (6/6)
In honor of his contributions to neuroscience, John Rubenstein of @UCSFPsychiatry and @UCSF is being inducted to the National Academy of Sciences following his election in 2020. Watch the #NAS159 livestream: https://t.co/9ikTzLt1CO