Ruchi Malik

neuroscientist @UCSF uncovering the mysteries of prefrontal inhibitory circuits | alum @UTAustin and @NCBS_Bangalore 🧠

[Ruchi Malik @Ruchimk]

My latest paper with @sohallab describes a novel long-range inhibitory (GABAergic) circuit in the mouse brain that allows the prefrontal cortex to exert top-down control on hippocampal activity during exploratory behavior.

Link: https://t.co/e9eIRMOhma

Summary 🧵 below...(1/6)

[Daniel Vogt @DVogtLab]

Finally getting this work out on Tsc1 in VIP+ interneurons. Great work from twitterless Jia Hu and @Ruchimk in the @sohallab.
https://t.co/U0A1zDi6xN

[Ruchi Malik @Ruchimk]

@mohebial Great news, congratulations Ali! They're lucky to have you🎉

[Mazen Kheirbek @mazen_kheirbek]

New paper from the lab out today! @jeremy_biane, @max_ladow and team describe how neural population dynamics in dorsal and ventral CA1 evolve with associative learning and outcome expectation. Full text here: https://t.co/lSMxx8zRGU

[Andrew MacAskill @MacAskillAF]

great to see this out! expertly crafted by @DaveKoop highlighting work from @mejoffe @Ruchimk @candelabellot and kirstie, hugo and hector who i dont have twitter handles for! PFC interneurons are cool! (esp when connected to hippocampus) https://t.co/ayS38jRaPO

[Edvard Ingjald Moser @EdvardMoser]

During navigation, landmarks are encoded not in single cells but in the collective hippocampal population dynamics. Excited to be part of this work with @anagelhus Sebastian O. Andersson @soledad_gcogno @MayBrittMoser @KISNeuro #KiloNeurons #Neuropixels
https://t.co/cWPUgQQEIy

[Nacho Sanguinetti🥸 @neuroetho]

Excited to see our paper on Unsupervised discovery of brain states in Hide and Seek out today on @CurrentBiology ! A massive exploration effort done by Bence Bagi @bagibence during his masters at @HumboldtUni in the @BrechtLab. That continued through years of pandemic.

[Ruchi Malik @Ruchimk]

@thomasjpace Thanks Thomas! We have not explored this, but it would be really interesting if similar inhib circuits exist for vis attn. One related study that comes to mind shows frontal long-range excit circuits recruiting local inhib for top-down control of vis actv
https://t.co/nnQ0ZdVYD2

[Ruchi Malik @Ruchimk]

My latest paper with @sohallab describes a novel long-range inhibitory (GABAergic) circuit in the mouse brain that allows the prefrontal cortex to exert top-down control on hippocampal activity during exploratory behavior.

Link: https://t.co/e9eIRMOhma

Summary 🧵 below...(1/6)

[Ruchi Malik @Ruchimk]

@vishnusreekr Thanks Vishnu! I made the illustrations in Adobe illustrator and used https://t.co/Yn7zUCkeTu to create GIFs.

Detailed instructions in this blog — https://t.co/Nj2VNjqPL0

[Ruchi Malik @Ruchimk]

@DenaDubal @sohallab Thanks Dena!

[Ruchi Malik @Ruchimk]

@yuwayway @sohallab Thanks Waylin!

[Ruchi Malik @Ruchimk]

@mmgergues @sohallab Thanks Mark!

[Ruchi Malik @Ruchimk]

Updated link: https://t.co/a6hVYooYQF

[Ruchi Malik @Ruchimk]

In conclusion: our study describes a novel anatomical pathway that allows the prefrontal cortex to alter information encoding and network activity in the hippocampus, thereby exerting top-down control over exploratory behavior. (6/6)

[Ruchi Malik @Ruchimk]

So well deserved! Congratulations John! 🎉

[National Academy of Sciences @theNASciences]

In honor of his contributions to neuroscience, John Rubenstein of @UCSFPsychiatry and @UCSF is being inducted to the National Academy of Sciences following his election in 2020. Watch the #NAS159 livestream: https://t.co/9ikTzLt1CO

[Ruchi Malik @Ruchimk]

@polybiotique Thanks Shruti! 😊