We would like to share this “swapping” protocol for NMR titrations with our user-friendly scripts hosted on Google-Colab for simulations of simple titration curves, swapping strategy, and early estimation of Kd. Hopefully it’s useful for the community. :)
Introducing in-cyclo NMR, a new method led by @GuillaumeMas2 at @biozentrum (@NatureComms)! This method combines high-resolution NMR with ATP regeneration & phosphate removal to resolve kinetics & dynamics of molecular machines - all in one experiment! https://t.co/cGCLUs9dCQ
We would like to share this “swapping” protocol for NMR titrations with our user-friendly scripts hosted on Google-Colab for simulations of simple titration curves, swapping strategy, and early estimation of Kd. Hopefully it’s useful for the community. :)
Out in @pnas today
Showcasing the power of NMR!
NMR and enzyme kinetics show USP7 enzyme transiently sampling a low-populated active state, and its disease-causing variant enhancing these dynamics
https://t.co/g1SmP4nBox
Stellar work by students Gabi Valles and Emilie Korchak
Professor Lewis Kay @LEK_Lab@UofT is honoured with the 2025 Alexander Hollaender Award in Biophysics awarded by the U.S. National Academy of Sciences @theNASciences for outstanding contributions to the field of biophysics https://t.co/qp0Aso53dl #NMRnews#NMRchat#NMR 🧲
Huge congrats 👏👏 to Rina Rosenzweig who has just been awarded this year’s @ICMRBS Founder's Medal for her truly impressive work on using advanced #nmr to elucidate the complex mechanisms of chaperones. @lab_rosenzweig
Had a little celebration yesterday for Lewis in honor of his 500th academic publication!
The poster contains the first page of all 500 papers, and his face is made of their figures.
Lewis wants to thank all his amazing trainees over the years for making it possible!
#NMRchat
If you’ve used UniProt, Ensembl, PDBe, or the AlphaFold Database, then consider helping the EMBL-EBI @emblebi (who hosts these resources) by filling out their survey
https://t.co/8o4jkvGw4j
@chris_waudby@AlexGuseman I used to have a free academic version and accidentally clicked ‘upgrade trial’ and lost my academic account. 😢My take-home message is ‘do not upgrade even they said it’s a free trial’😅
and the published version is now out in @PNASNews!
If you are interested in #AlphaFold or intrinsically disordered regions #IDRs, take a look 👇 We've added a lot of new data and analyses.
https://t.co/7Umab1YthN
1/7 Ever wondered if there is more to the AlphaFold2 predictions of IDRs than spaghetti 🍝?
Isn’t AF2 another disorder predictor? Or has it learned something more subtle and interesting hidden within IDR sequences?
To find out, read our new preprint https://t.co/ZDLvIie72r
🧵
A bright future lies ahead for #NMR !
@bhu_vaibhav@G_T_Heller and I have written a review about NMR in the era of AI. Maybe we are biased - but we think that a combination of AI and NMR will further revolutionise structural biology
https://t.co/BlDRtwap6l
@UCLLifeSciences
“It’s not spaghetti” learning about RNA Editing from the amazing @jenheemstra at the inaugural session of the Tremaine Speaker Series @UofGCEPS join us for one of the amazing presentations this week featuring Dr. Heemstra https://t.co/GN6NNoofEB