Ruth Amy Purcell

🦠🩸🧬🧫🌱🇦🇺🇿🇦

[Ruth Amy Purcell @RuthAmyPurcell]

Our paper exploring effects of solid tumor malignancy-associated inflammation upon COVID-19 vaccine-induced antibodies is live! We show that while dysregulated inflammation impairs neutralization, variant cross-reactive Fc effector functions remain robust.
https://t.co/4Mvq4zWDFV

[Ruth Amy Purcell @RuthAmyPurcell]

And of course, none of this would have been possible without the input from a hugely collaborative, interstate clinical team and the support of many scientists and clinicians @TheDohertyInst @BiologyANU

[Ruth Amy Purcell @RuthAmyPurcell]

Our paper exploring effects of solid tumor malignancy-associated inflammation upon COVID-19 vaccine-induced antibodies is live! We show that while dysregulated inflammation impairs neutralization, variant cross-reactive Fc effector functions remain robust.
https://t.co/4Mvq4zWDFV

[Ruth Amy Purcell @RuthAmyPurcell]

We found that inflammatory biomarkers (incl. cytokines, agalactosylated IgG, and atypical B cells) were elevated in solid tumor patients and were negatively correlated with neutralizing antibody responses, but not with antibodies against conserved epitopes or with Fc functions.

[Doherty Institute @TheDohertyInst]

In a recent study published in Science Advances, researchers explored whether adding IgG4 antibodies in blood samples would affect vaccine-induced immunity. 🔗https://t.co/S8ZLpEImrA @UniMelbMDHS @TheRMH @UniMelb

[Hyon-Xhi @Hyonxhi]

Nice work by Lauren Burmas, our former honours/RA and the team @viralvaxlab looking at the impact of varying your prime-boost vaccine site.

[Lachlan Deimel on BlueSky @LachlanDeimel]

Affinity maturation happens outside of the GC? 🤯*
* Well, kinda... PB/PCs leave the GC and expand proportional to their affinity.

Massive kudos to the legendary Andrew MacLean and the rest of the @NussenzweigL team. Check out the pre-print here. https://t.co/BactQDjy4h

[Science Translational Medicine @ScienceTM]

A new generation of vaccine #adjuvants tailored for the pediatric immune system could help overcome longstanding gaps in the design of #InfectiousDisease vaccines for children, according to a new Viewpoint from researchers at @NIAIDNews.
https://t.co/kDCEsG4IzP

[Nathan Lo @NathanLo3579]

🧵 1/N How often should I get a #COVID19 booster vaccine? Our new article published in @NatureComms estimates benefit of different frequencies of COVID vaccines against severe disease by risk group (age, immunocompromised status). Check it out here! https://t.co/y3Oosh6NAw

[Ruth Amy Purcell @RuthAmyPurcell]

We love antibodies 😍 Until they cause spicy experimental artefacts 😳
Stay safe and validate your antibody detectors thoroughly 😅

[Clinical & Translational Immunology @ClinTransImmuno]

Genetic variations in Immunoglobulin G can impact antibody assessment, with certain clones showing preference for specific IgG variants, potentially leading to misinterpretation of responses
@ASImmunology @WileyGlobal
https://t.co/pIs304u7ss

[I Am Dr. Sam 👩‍🔬 @SamanthaKDavis1]

Check out this great work by @EbeneRHaycroft and co. looking at antibody glycosylation in the humoral response to SIV-TB coinfection in 🐒👇

[Kevin John 🧪🧩 @Kev_in_Science]

How do #mucosal antibodies respond after #vaccination or #covid breakthrough infection? 🤔

Do previous exposures shape future #humoral responses?

Our work is finally out as twin publications in @JCI_insight and @ImmunolCellBiol

Short🧵to follow 😉

[I Am Dr. Sam 👩‍🔬 @SamanthaKDavis1]

Another piece of work from my phd and from @EbeneRHaycroft masters thesis is finally out! Read it here 👇 key points are broken down in this 🧵 #COVID19 #phdlife #Researchpaper #Antibodies https://t.co/pJrVrSjrPU

[Ebene Regina Haycroft @EbeneRHaycroft]

🥳 So happy to share my first, first-coauthored paper is finally out! 🥳

What did we do! Well, we looked at 1) #antibody immunity to #SARSCoV2 variants after #vaccination and 2) natural ACE2 polymorphism on affinity to #RBD! A nice summary of key take homes linked below 🦠 1/2

[Kevin John 🧪🧩 @Kev_in_Science]

Can future vaccines be "personalised"? 🤔

Do different populations benefit from different vaccine formulas? 👶🏼🧓👩🏽

What infectious diseases are reduced by functional antibodies? 🧪🧬

Find out all that and more in @RuthAmyPurcell 's jam-packed review on vaccines & antibodies 🎉

[Ruth Amy Purcell @RuthAmyPurcell]

6/n: By understanding the mechanisms of altered antibody responses in immunocompromised individuals, we may be able to tailor vaccination strategies to selectively boost impaired immune features and enhance protection.

[Ruth Amy Purcell @RuthAmyPurcell]

🧵1/n: Can rational induction of antibodies with non-neutralising functions contribute to improved vaccine effectiveness in vulnerable populations? 💉👴🤰

https://t.co/4PfK9ptMdO

[Ruth Amy Purcell @RuthAmyPurcell]

5/n: Immunocompromised populations have characteristic Fc modifications.
For example, specific Fc glycosylation patterns are associated with altered levels of inflammation.
However, certain vaccination strategies can also drive distinct changes to Fc effector function profiles 🤔