Sviatoslav Chekhun

[Cancers MDPI @Cancers_MDPI]

T1 substaging, tumour budding & CDH1 loss on routine TURBT slides may help stratify BCG failure risk in high-grade NMIBC — no extra cost. New review in @Cancers_MDPI. @MediPharma_MDPI
✍️by Núria Sala-González, @SChekhun et al
📌Access the full paper here: https://t.co/baZ6z7w47g

[Tom Powles @tompowles1]

EMA approval of perioperative EVP in cisplatin ineligible muscle invasive bladder cancer occurred today.

This is a big step towards curing more patients

Extension to cisplatin eligible patients soon - we hope (based on +ve OS in B15 study)

Bladder surgery sparing trials next (EV209 and 309)

https://t.co/6f0wedUEXZ

[Enrique Grande @drenriquegrande]

⚡️ Real-world ARON-2EV: enfortumab vedotin after platinum + pembrolizumab in mUC achieves mOS 12.3 months and ORR 45%.
Prior pembro response predicts better EV outcomes, but activity persists even after PD.

#BladderCancer @EUplatinum

https://t.co/npmYglreVf

[Oscar Tahuahua @drtahuahua]

Review - Germline Mutations as Cancer Drug Targets https://t.co/36YJlqTGBa @OncoAlert @CD_AACR

[Santhosh Ambika @RenoHemonc]

@OncBrothers @AlanBryce9 @CancerNetwrk @cityofhope @DrKarineTawagi @BijoyTelivala @dr_yakupergun @DrYukselUrun @MikeSerzanMD @sophia_kamran @nataliagandur @crisbergerot Need better pt selection in mHSPC

[Johanna Nyman @JohannaNyman5]

“Russia will not stop. What we see is pure imperialism. Pure use of violence as a political means.”

— Danish PM Mette Frederiksen

[Roman Sheremeta 🇺🇸🇺🇦 @rshereme]

This is how the U.S. looks like to the rest of the world.

[Jun Kim @Jun_kiim]

Published in Nature (2023), Kruse et al. (Tüting lab) demonstrate that adoptively transferred CD4+ T cells alone—but not CD8+ T cells—can eradicate melanoma tumors completely lacking both MHC class I and II expression.

These findings challenge the current paradigm of cancer immunotherapy, which predominantly focuses on CD8+ cytotoxic T cells whose effectiveness is limited by MHC loss and immunosuppressive TME. Historically viewed merely as ‘helper’ cells, CD4+ T cells instead have a critical yet underappreciated capacity for antitumor immunity independent of CD8+ cells. Intriguingly, CD4+ T cells do not directly infiltrate tumors in the same way CD8+ T cells do. Rather, they profoundly reshape the tumor immune landscape by recruiting and functionally reprogramming myeloid cells. These myeloid cells mature into potent interferon-activated APCs and robust iNOS-expressing tumoricidal effectors.

This study uncovers exciting therapeutic opportunities by revealing the potential of CD4+ T cells to complement CD8+ T cells and NK cells, paving the way for innovative strategies against immune-evasive cancers.

[Hidehito HORINOUCHI @HHorinouchi]

⏰NOW OUT‼️#ELCC25
🔥MARIPOSA🦋: Amivantamab plus lazertinib vs osimertinib in 1L EGFRm advanced NSCLC: Final OS
🎙️Prof. James Yang
🎯OS HR 0.75 (95%CI: 0.61-0.92)
🎯Anticipated to prolong mOS by at least 1⃣2⃣mo
✅NCT04487080
#LCSM @OncoAlert @myESMO @IASLC

[Jürgen Nauditt 🇩🇪🇺🇦 @jurgen_nauditt]

The time for putin's friends in Hungary and Serbia is over.

Budapest (Video 1)
A huge rally of the opposition, which is already ahead of Orban in the polls, is calling for early elections. Peter Magyar explains:

Spring is coming to Hungary, together we will end Orban's winter.

Belgrade (Video 2)
The most massive protest – according to various estimates, up to 1 million people took to the streets and demanded Vucic's resignation. The presidential residence is surrounded by special forces and troops.

Hungary and Serbia are Moscow's most important allies in Europe. But it seems as if their "stability" is starting to crack.

[Giorgi Revishvili @revishvilig]

Very significant statements by President Macron:

We cannot forget that Russia began to invade Ukraine in 2014 and we then negotiated a ceasefire in Minsk. And the same Russia did not respect this ceasefire.

Today, we can no longer take Russia's word for it. 1/5⬇️

[Kareem Rifai 🌐 @KareemRifai]

After Vance accused Zelensky of not saying thank you, Zelensky is now tweeting individual thanks to every single world leader expressing solidarity with Ukraine.

[Dean Blundell🇨🇦 @ItsDeanBlundell]

American Veteran has a word for Trump and Zelensky.

Take two mins…

[International Society of Liquid Biopsy @isliquidbiopsy]

🧬 Liquid Biopsy in Clinical Practice: Past, Present & Future🩸

A new review explores the evolution, applications, and future directions of liquid biopsy in oncology. Here are the key insights:

🔬Technologies & Biomarkers

✅ Circulating Tumor Cells (CTCs) – Enrichment & detection methods (PCR, IHC, FISH, scRNA-seq)
✅ Circulating Tumor DNA (ctDNA) – PCR & NGS-based detection for genomic alterations
✅ Exosomes – Advanced methods for isolating tumor-derived extracellular vesicles

📊Clinical Applications

✅ Early Cancer Detection– Liquid biopsy enhances non-invasive screening
✅ Cancer Staging & Prognosis– Stratifies patients based on risk & molecular profiling
✅ Therapy Guidance – Detects actionable mutations like ESR1, PIK3CA, EGFR, ALK for precision medicine
✅ Treatment Response Monitoring – Tracks minimal residual disease (MRD) & therapy resistance

🚀Advancing Liquid Biopsy for Multi-Cancer Screening

✅ Emerging multi-cancer detection technologies: CCGA3, CancerSEEK, THUNDER, DETECT-A, PATHFINDER
✅ AI & machine learning integration for enhanced diagnostic accuracy

🔮Future Directions

✅ Standardization & Validation – Steps to clinical utility
✅ Multi-Omics Approach – Integrating genomics, transcriptomics, and proteomics
✅ Ex Vivo Models – Using CDX mouse models for precision therapy testing

🌍Liquid biopsy is revolutionizing oncology—enhancing early detection, personalized treatment & real-time monitoring.

🔗 Read the full study: https://t.co/NRKdWCiSah

@DrYukselUrun @ChristianRolfo @ElJanLe @UmbertoMalapel1 @oncodaily @ErulEnes @drgandara @MJOSESERRANO19 @CHematology @Elsevier_Med

#LiquidBiopsy #PrecisionOncology #ctDNA #CancerDetection #ISLB 🚀

[Volodymyr Zelenskyy / Володимир Зеленський @ZelenskyyUa]

Three years of resistance. Three years of gratitude. Three years of absolute heroism of Ukrainians. I am proud of Ukraine! I thank everyone who defends and supports it. Everyone who works for Ukraine. And may the memory of all those who gave their lives for our state and people be eternal. 🇺🇦🇺🇦🇺🇦

#SupportUkraine

[Cancer Cell @Cancer_Cell]

Online Now: Contrasting cytotoxic and regulatory T cell responses underlying distinct clinical outcomes to anti-PD-1 plus lenvatinib therapy in cancer https://t.co/H8aXmgT7OG

[Nature Reviews Cancer @NatureRevCancer]

NEW content online! Cross-priming in cancer immunology and immunotherapy https://t.co/j3bqHUJ8ma

[NEJM @NEJM]

A new review describes basic and translational research on the complex physiological processes of hunger, which regulate feeding habits and are influenced by socioeconomic, cultural, and behavioral factors. Read the full review: https://t.co/FPfY2tHJix

[Cancer Cell @Cancer_Cell]

Cytokines in cancer https://t.co/M67vwIR62c

[Eric K. Singhi, MD @lungoncdoc]

Lung Cancer Wrapped > @Spotify Wrapped

Here’s your 2024 Year in Review of @FDAOncology approvals in lung cancer!

@US_FDA @OncoAlert @OncBrothers #lcsm