SamesLab

[SamesLab @SamesLab]

- introduced in the context of the effects of ibogaine and iboga alkaloids at monoamine neurotransmitter transporters.

[SamesLab @SamesLab]

How does ibogaine accomplish its wide variety of therapeutic and psycho-social effects?
This article (@J_A_C_S) is the foundational piece of a new theory - the iboga matrix pharmacology –🧵
https://t.co/3bIbHX1C49

[SamesLab @SamesLab]

Check out the Nature Research Briefing on this: https://t.co/MuUiThBS8g

[SamesLab @SamesLab]

A Molecular Tale of Toad Psychedelic and the Role of 5-HT1A Receptor in Psychedelic and Therapeutic Effects: https://t.co/Ok1TAm8RDr
Congratulations to @LankriDavidIL and Audrey and all coauthors in this collab with @WackerLab and @ScottRusso, published in @Nature.

[Daniel Wacker @WackerLab]

Lessons from a Toad Psychedelic about the Role of different Serotonin Receptors in Psychedelic Physiology: https://t.co/pbVhYswK6C
Congrats to Audrey and @LankriDavidIL in this collab with @SamesLab and @ScottRusso published in @Nature

[BryanRoth @zenbrainest]

Wow--amazing paper from @WackerLab on #psychedelics in @nature !
Structural pharmacology and therapeutic potential of 5-methoxytryptamines
https://t.co/tyimKbDvUZ

[SamesLab @SamesLab]

SERTlight, a fluorescent substrate of SERT, enables the visualization of serotonergic neurons without genetic manipulation. It doesn't modulate serotonin/other receptors, providing a new tool for the study of the 5-HT system & therapeutics. @J_A_C_S https://t.co/63e5nVHSVH

[SamesLab @SamesLab]

CC: @zenbrainest @RCarhartHarris @markfrommacq @ee_schenberg @softnucleophile @CassianoDiniz3

[SamesLab @SamesLab]

Thank you for your comments and questions, in response we elaborate here. (Thread)

[SamesLab @SamesLab]

This paper claims psychedelics induce neuroplasticity via direct activation of the BDNF receptor TrkB https://t.co/iaPsRquevz
Before you reach a conclusion, see our paper @scisignal; 40K+ compounds were tested, none activates TrkB!
https://t.co/4d0En6zhlV #psychedelics

[SamesLab @SamesLab]

In our view, if the latter was the case, we would have seen a signal with > 40K compounds and millions of peptides. However, to be clear, we have not published on psychedelics and TrkB activity yet. Stay tuned, we aim to report on this topic in the near future. (12/12)