Samik Kumar Bandyopadhyay

Surgeon and Creative Writer. Interest:Education and the World, Ex Associate Professor RG Kar Medical College

[Parmita Mishra @parmita]

RAS finally getting drugged is one of the great stories in modern biology, and almost nobody outside oncology understands why it's such a big deal.

YOU'LL LEARN SOMETHING AWESOME TODAY.

i am going to keep this as understandable (and simple) as i can.

OPEN THE THREAD.

🧵

[Crémieux @cremieuxrecueil]

Eli Lilly has done it.

They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol.

That means they'll be able to effectively prevent most heart disease with a single infusion!

[Chris Nahm @chris_nahm]

The best surgeons combine grit with insight. It is quite possible to have one without the other. Grit is the ability to keep showing up, persist under pressure, and do the work. Insight is the ability to know your limitations, receive feedback, recognise your weaknesses.

[Samik Kumar Bandyopadhyay @SamikKumarBand1]

Outcomes after pancreatic resections for secondary tumors in the pancreas: a single-center experience - Journal of Gastrointestinal Surgery https://t.co/iZeucXSzld

[Samik Kumar Bandyopadhyay @SamikKumarBand1]

Survival by treatment recommendation and treatment receipt among older adults with localized pancreatic cancer - Journal of Gastrointestinal Surgery https://t.co/PV43qZSKA0

[Samik Kumar Bandyopadhyay @SamikKumarBand1]

Multivisceral resection for pancreatic ductal adenocarcinoma with adjacent organ invasion: a propensity score–matched analysis - Journal of Gastrointestinal Surgery https://t.co/DMwrlQoLW6

[Samik Kumar Bandyopadhyay @SamikKumarBand1]

https://t.co/t3kS4ut1aS

[Samik Kumar Bandyopadhyay @SamikKumarBand1]

@asgbi @MarkCheetham @RCSEd @RCSnews @RCSI_Irl @rcpsglasgow @pferrada1 @pratikroy @NickWatsonSurg @ACPGBI_PLG @Augishealth @SAGES_Updates @BJSAcademy @SurgeryHPB @DimDamask @2eyes1keyboard @KateHancorn It was really a great feeling to meet again… Regards from Samik.
My number is 00 44 7424 656171

[Samik Kumar Bandyopadhyay @SamikKumarBand1]

@asgbi @MarkCheetham @RCSEd @RCSnews @RCSI_Irl @rcpsglasgow @pferrada1 @pratikroy @NickWatsonSurg @ACPGBI_PLG @Augishealth @SAGES_Updates @BJSAcademy @SurgeryHPB @DimDamask @2eyes1keyboard @KateHancorn

[Jason R. Williams, MD, DABR @jasonwilliamsmd]

45% of patients on daraxonrasib developed acquired resistance, converging on the same target through different routes. KRAS Y64 mutations disrupt the molecular glue directly. Y71 mutations and hypoactive BRAF enhance native RAS-RAF binding so the inhibitor can't displace it. One protein, multiple escape doors. Cancer is pleiotropic. The chemistry has to be.

[Avi Roy @agingroy]

Pancreatic cancer kills most patients within months. We've known which protein is responsible since the 1980s. The problem? It's completely smooth. Drugs need something to latch onto, and this protein has nothing.

For 40 years, every attempt failed.

Daraxonrasib asked a different question: what if we don't latch on? Instead, it recruits another protein to smother it. Sits right on top. Switches it off.

Phase 3 trial: patients lived twice as long. A daily pill instead of IV chemo.

That same protein is broken in 1 in 4 human cancers.

[Hong Jae Chon @hongjaechon]

🎯 A potential paradigm shift in early HCC detection! The new CLiMB study in @JHepatology challenges ultrasound-only HCC surveillance.
👉 Overall Sensitivity: HelioLiver Dx blood test (47.8%) vs Ultrasound (28.3%)
👉 Sensitivity for HCC ≤2 cm: HelioLiver Dx (28.6%) vs Ultrasound (0%)
This blood-based approach may help reduce barriers to surveillance and enable earlier detection when curative treatment remains possible.
@ILCAnews @myESMO @ASCO @EASLnews
Full text: https://t.co/jZkFhBvnaT
#HCC #LiverCancer #Oncology #HelioLiverDx #EarlyDetection

[Samik Kumar Bandyopadhyay @SamikKumarBand1]

@tjt4002 My heartiest wishes to both of you..,keep doing good for the people around… May the blessings of Debadideb be with you all..

[Samik Kumar Bandyopadhyay @SamikKumarBand1]

Cirrhosis, portal hypertension and hepatocellular carcinoma: a stage-based approach | Nature Reviews Gastroenterology & Hepatology https://t.co/DSx3E86nUz

[Samik Kumar Bandyopadhyay @SamikKumarBand1]

Cancer-associated fibroblasts regulate DNA repair in pancreatic cancer through NDRG1-mediated R-loop processing | Nature Cell Biology https://t.co/jFpjJmAKLE

[Samik Kumar Bandyopadhyay @SamikKumarBand1]

@smritiirani @narendramodi It is the beginning of a new Hope..

[Samik Kumar Bandyopadhyay @SamikKumarBand1]

@smritiirani Namoskar janben. Bharat Mata ki Jai..

[大島 晋 | 大動脈外科 (Susumu Oshima | Aortic surgery) @SusumuOshima]

1/8
— The First Lesson as a Surgeon, Inherited from Dr. Yamamoto —
🎯 Let’s start with a question.
There’s a small circle drawn on a piece of paper in front of you.
“Put a dot inside this circle.”
How do you do it?
A: Slowly and carefully, making sure it never goes outside.
B: Quickly — just a quick flick, focusing on speed.
Which is the “right” answer?

[IHPBA @IHPBA]

FINAL REMINDER: Deadline for applications - 30 April 2026

IHPBA are seeking dedicated and enthusiastic members who are ready to contribute their time, expertise, and passion to help advance our mission.
Apply here: https://t.co/XaP9paOUan
#ihpba #eahpba #ahpba #aphpba

[Paolo Ciracì @p_ciracimd]

Daraxonrasib + gemcitabine/nab-paclitaxel in 1L RAS-mutated mPDAC shows manageable safety profile and encouraging early efficacy signals supporting the initiation of a global 3-arm phase 3 study

👉 https://t.co/O0G4bfoUB9

@OncoAlert #AACR2026