Samuel Kilcher

Designer of genomes, phage enthusiast, rock climber, views are my own.

[Samuel Kilcher @SamuelKilcher]

I am thrilled to announce that PhalconBio has secured £1 million grant funding from @PACE_AMR to propel our lead anti-Pseudomonas program.

Thank you for the support and recognition of our platform technology! 🚀💪🥂
#phage #engineering #AMRsolutions

https://t.co/CNeJWoItfi

[Samuel Kilcher @SamuelKilcher]

Urine Good Hands! Engineered phages to detect and treat #UTIs.

🙏 to @phagedirectory for publishing an interesting behind-the-scenes article.

🙏@MattDunne_1 Jiemin Du @MeileSusanne @MartinLoessner @PhageForward @LeitnerLorenz Thomas Kessler and team!

https://t.co/3CpIMl8Z9N

[Samuel Kilcher @SamuelKilcher]

What happens when you combine two #precision #antimicrobials?

➡️Enhanced #UPEC killing using #engineered #phages that release a #colicin from infected target-bacteria!
➡️See effect of this two-pronged attack in green (supplementary data from https://t.co/rpHoX2efMX)

[ETH Zurich @ETH_en]

Pathogens that cause urinary tract infections #UTIs are becoming increasingly resistant to #antibiotics. ETH researchers developed a rapid test and a new therapeutic approach using bacteria-​infecting viruses known as #phages.@SamuelKilcher @MattDunne_1 https://t.co/aoQlJD5y94

[Samuel Kilcher @SamuelKilcher]

2 papers out @NatureComms: #Engineered #phages to detect (https://t.co/IlnWYaqXVs) and treat (https://t.co/rpHoX2eNCv) #UTIs. Big team effort! 🙏🙏🙏 to @MeileSusanne Jiemin_Du @MartinLoessner @MattDunne_1 + >20 contributors @eth_en @derbalgrist @UZH_en
Pic: Happy last authors 😀

[Samuel Kilcher @SamuelKilcher]

For #phage #engineering geeks:
If you are interested in modifying the genomes of virulent #Enterococcus phages, you may want to have a look at Figure 2 of our recent preprint.
🧬Cas9 is a highly efficient counter-selection tool 🧬
🧬100 % success rate🧬
https://t.co/EC7WNFbW8A

[Samuel Kilcher @SamuelKilcher]

Great study covering many applications of phage engineering. Congrats!
Really enjoyed seeing in vivo data comparing wildtype vs. replication-deficient phages 👍

[Hiroki Ando 安藤 弘樹 @Ando169]

Congrats to our team!

Synthetic engineering and biological containment of bacteriophages.

https://t.co/hxlMo2iNyc

[Samuel Kilcher @SamuelKilcher]

Proud to present our work on engineered #phage-based urine #diagnostics. Huge team effort led by @MeileSusanne Jiemin Du @MattDunne_1 + much support from @LeitnerLorenz @PhageForward Thomas Kessler @MartinLoessner + 16 more authors! @ETH_en @derbalgrist
https://t.co/EC7WNFboj2

[Samuel Kilcher @SamuelKilcher]

Nice phage engineering work-around for phiKZ-like jumbo phages!

[Joe Bondy-Denomy @joeBondyDenomy]

Here, @jingwen_guan presents a new way to engineer phage genomes, using Cas13a + an Acr protein! We developed this because our favorite jumbo phage, phiKZ had no genetic tools. We are now using this to understand the jumbo phage secrets. short🧵https://t.co/Y2NCazuLMF

[Samuel Kilcher @SamuelKilcher]

@MattDunne_1 @ETH_en I echo that! And a big thank you to the students @ETH_en, to @marschall_jonas, and to @PhageForward for help and fruitful discussions. We are grateful to the patients and the clinical care team @derbalgrist for providing urine to test our phage antimicrobials!

[Samuel Kilcher @SamuelKilcher]

How to tackle #UTIs with engineered #phage? Proud to present: https://t.co/Jf1sFuvwST. Big shout-out to first authors Jiemin Du + Susanne Meile and co-corresponding @MattDunne_1. Thanks @LeitnerLorenz, Thomas Kessler, and @MartinLoessner for all the support! @ETH_en @derbalgrist

[Matthew Dunne @MattDunne_1]

Out today👨‍🔬! Characterization of tail fibers and tailspikes from broad range E. coli #phages EP335 and EP75. Shout out to co-authors Sander Witte & Joel T. van Mierlo @Micreos, @LeaZinsli, Cassie Matter & @MartinLoessner @ETH, & Rafael G-Serrano. 👏
https://t.co/AVkR5IVUwA

[Samuel Kilcher @SamuelKilcher]

Nothing cheers me up more than marveling at cumulative incidence curves of the Pfizer/BioNTech and Moderna vaccines 😅 #VaccinesWork

[Samuel Kilcher @SamuelKilcher]

Excited to share our thoughts on improving #phagetherapy through #synbio and genome engineering:

https://t.co/pOdlrnEeGw

Congrats to the 2 first authors @FlyGeneticsGuy and Bryan Lenneman and to @MartinLoessner and @timlu for a great collaboration.

Artwork by @FlyGeneticsGuy

[Samuel Kilcher @SamuelKilcher]

@MattDunne_1 Time to get out of crystallography? 😅

[The Nobel Prize @NobelPrize]

BREAKING NEWS:
The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”

[Samuel Kilcher @SamuelKilcher]

@MercerLab Looks a bit like when we arrived 😅

[Samuel Kilcher @SamuelKilcher]

Another great example of phage-antibiotic synergy, congrats! Phage-resistance often comes at a cost: incrased antibiotic susceptibility, decreased virulence, etc... #CombinationTherapy

[PHD Comics @PHDcomics]

Happy Postdoc Appreciation Week