I am thrilled to announce that PhalconBio has secured £1 million grant funding from @PACE_AMR to propel our lead anti-Pseudomonas program.
Thank you for the support and recognition of our platform technology! 🚀💪🥂
#phage#engineering#AMRsolutions
https://t.co/CNeJWoItfi
What happens when you combine two #precision#antimicrobials?
➡️Enhanced #UPEC killing using #engineered#phages that release a #colicin from infected target-bacteria!
➡️See effect of this two-pronged attack in green (supplementary data from https://t.co/rpHoX2efMX)
Pathogens that cause urinary tract infections #UTIs are becoming increasingly resistant to #antibiotics. ETH researchers developed a rapid test and a new therapeutic approach using bacteria-infecting viruses known as #phages.@SamuelKilcher@MattDunne_1 https://t.co/aoQlJD5y94
For #phage#engineering geeks:
If you are interested in modifying the genomes of virulent #Enterococcus phages, you may want to have a look at Figure 2 of our recent preprint.
🧬Cas9 is a highly efficient counter-selection tool 🧬
🧬100 % success rate🧬
https://t.co/EC7WNFbW8A
Great study covering many applications of phage engineering. Congrats!
Really enjoyed seeing in vivo data comparing wildtype vs. replication-deficient phages 👍
Here, @jingwen_guan presents a new way to engineer phage genomes, using Cas13a + an Acr protein! We developed this because our favorite jumbo phage, phiKZ had no genetic tools. We are now using this to understand the jumbo phage secrets. short🧵https://t.co/Y2NCazuLMF
@MattDunne_1@ETH_en I echo that! And a big thank you to the students @ETH_en, to @marschall_jonas, and to @PhageForward for help and fruitful discussions. We are grateful to the patients and the clinical care team @derbalgrist for providing urine to test our phage antimicrobials!
Out today👨🔬! Characterization of tail fibers and tailspikes from broad range E. coli #phages EP335 and EP75. Shout out to co-authors Sander Witte & Joel T. van Mierlo @Micreos, @LeaZinsli, Cassie Matter & @MartinLoessner@ETH, & Rafael G-Serrano. 👏
https://t.co/AVkR5IVUwA
BREAKING NEWS:
The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”
Another great example of phage-antibiotic synergy, congrats! Phage-resistance often comes at a cost: incrased antibiotic susceptibility, decreased virulence, etc... #CombinationTherapy