Scicomm Media

We’re the team behind @hubermanlab, @DrAndyGalpin and @davidsenra

[Andrew D. Huberman, Ph.D. @hubermanlab]

The new Huberman Lab episode is out: Peptides: The Science, Uses & Safety | Dr. @AbudBakri

0:00 Abud Bakri
3:33 What are Peptides?, Receptors
6:26 BPC-157, Discovery, Animal Proteins
11:19 BPC-157, Animal Data, Regeneration
12:27 Sponsors: Eight Sleep & Lingo
14:51 BPC-157, Regeneration & Healing, Neurological Effects
19:27 Adverse Events, Clinical Trials & Legality of BPC-157
29:41 GLPs & Compounding Pharmacy; Peptides & Gray Market
35:25 Manufacturing, Compounding Pharmacies, Gray Market, Black Market
41:32 Peptides & Tumor Growth?; Angiogenesis
45:17 Sponsor: AG1
47:01 Pharmaceutical Patents, Clinical Trials for BPC-157, Potential Outcomes
54:19 BPC-157 Healing, Patient Experiences
1:01:22 Physician Counsel, FDA Legality, Malpractice
1:07:25 Pinealon, Epithalon, Discovery; Sleep & Cognitive Performance, Risks
1:18:17 Sponsor: Function
1:19:55 Pineal Age Deterioration, Epithalon, Eye Health
1:29:38 Thymus, Age Shrinkage; Thymosin Alpha-1, Immune Function
1:38:13 TB-500; Pet Health; Thymic Peptide Doses, Thymulin, Zinc
1:49:13 Sponsor: LMNT
1:50:33 GHK-Cu (Copper GHK), Collagen
1:55:32 Illness Recovery, Thymic Score, Tool: Blood Test & Immune Cell Counts
2:04:01 Growth Hormone Secretagogues, Age Decline, Cancer Risk, Insulin
2:15:36 GHK-Cu, Topical Cream, Red Light Therapy
2:20:25 GLPs, Discovery, Physical & Cognitive Long-Term Effects, Fertility
2:33:53 Retatrutide; Drug Patents & Nomenclature
2:39:03 Peptides: Women Reproductive Disorders; TBI, Neurologic Effect; Safe Sources
2:45:34 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter

Includes paid partnerships.

[Scicomm Media @scicomm]

Tomorrow's Huberman Lab episode is with Dr. @AbudBakri, MD, a physician and clinician specializing in peptide therapeutics and their applications in healing, immunity, and longevity.

Dr. Bakri and @hubermanlab discuss BPC 157, the difference between GLP-1s and the "Russian" peptide bioregulators, thymus health and immunity, and overlooked markers of longevity.

[Scicomm Media @scicomm]

@MontanaHODL21M @davidsenra @RickRubin At Rick's studio Shangri-La

[Rob Mohr @R_Mohr]

One of my favorite episodes so far.

The conversation, the setting, everything.

I asked Rick if we could record at Shangri-La less than 24 hours before this was scheduled. Huge thanks to him, the team at Shangri-La, and the @scicomm crew for making it happen last minute.

[David Senra @davidsenra]

My conversation with @RickRubin

0:00 Less Is More But Harder
2:00 Def Jam From The Dorm Room
4:00 Capturing Club Energy On Record
6:00 Going Deep On Influences
12:30 Why Reduced By Rick Rubin
14:00 Beatles Structure Meets Rap
16:00 The Ruthless Edit
19:30 Eminem: The Most Obsessive Artist
22:00 Lazy Workaholic
25:30 Protecting The Moment Of Magic
29:00 Dana White And Becoming A Podcaster
32:30 Professional Listener
44:00 Fishing And Showing Up
47:00 Johnny Cash And Constraints
55:30 Church Business vs. Banking Business
58:50 Run On Intuition Alone
1:01:00 Jay-Z vs. Eminem Process
1:04:30 In Service Of The Artist
1:09:00 Work As Diary Entries
1:13:30 Four Ways Success Destroys You
1:16:00 How To Sustain Success
1:21:00 The House On The Mountain

Includes paid partnerships.

[David Senra @davidsenra]

The Man Behind Grand Theft Auto VI and a $45 Billion Media Empire: Strauss Zelnick

Strauss Zelnick has been one of the most powerful people in media for decades, and most people still don't know his name. He took over Take-Two Interactive while the company was under criminal investigation and was 6 months from bankruptcy. It had one product that made money (GTA); everything else was unprofitable. Since then, Take-Two has gone from a $700 million disaster to a $45 billion empire built on Grand Theft Auto, Red Dead, and NBA 2K. His management philosophy fits on a napkin: hire the best creative talent on Earth, don't interfere, and run a rational company. He's been doing that for more than 4 decades. This conversation was awesome.

0:00 Hostile Takeover With No Money
1:29 Becoming the New Media Guy
3:58 Lessons From Entertainment History
9:44 Why Hollywood Feared Games
11:52 Fox Turnaround and Barry Diller
20:54 Rupert Murdoch and High Stakes Calm
26:20 Taking the Leap to Crystal Dynamics
38:04 Bootstrapping Without Capital
43:57 Carl Icahn Connection
47:01 Take Two Proxy Coup
56:36 Turnaround Cost Cutting Playbook
1:01:37 Leading Creative Geniuses
1:06:24 Rationality Beats Magic
1:07:54 Borderlands Bet
1:09:28 GTA Timelines Pressure
1:11:22 Specific Goals Visualization
1:21:34 Service Leadership Mindset
1:31:52 Media vs. Entertainment
1:34:22 AI Productivity Reality
1:36:08 Why Hits Surprise

Includes paid partnerships.

[David Senra @davidsenra]

My conversation with @danawhite, president and CEO of the @UFC.

0:00 Founders Are the Best Storytellers
1:04 Buying the UFC for $2M
2:51 Excellence Is the Capacity to Take Pain
7:58 One Good Night's Sleep and "Fuck It, Let's Keep Going"
10:53 The Ultimate Fighter: A $10M Bet-It-All Moment
13:12 The Napkin Deal With Spike TV
22:00 Leaving Spike TV and the Phil Duman Story
28:24 First Event Profitable: What He Does Differently Now
32:30 Why Dana Sits Ringside Watching a Screen
34:07 Building a Team That Can Read His Mind
45:10 "Who the Fuck Are You and What Have You Done?"
51:55 Selling the UFC for $4+ Billion
57:32 Not Cutting a Single Employee During COVID
1:03:30 Firing a Sponsor Who Told Him How to Vote
1:07:45 There Is No Plan B
1:09:00 Joe Rogan: Doing the First 12 Fights for Free
1:12:37 Loyalty Is the Most Important Thing

Includes paid partnerships.

[Andy Galpin, PhD @DrAndyGalpin]

It starts with discipline and hard work.

@KenRideout_ tomorrow on Perform with Dr. Andy Galpin.

[David Senra @davidsenra]

David Baszucki. Roblox.

Tomorrow. April 26, 2026.

Available everywhere you get podcasts.

@DavidBaszucki @Roblox

[Andy Galpin, PhD @DrAndyGalpin]

Perform with Dr. Andy Galpin is back.

New episode: How to Build a Strong Core & Abs

0:00 Core Training Myths
4:22 Why We Train Abs Wrong
7:27 Abs vs Core Explained
11:17 Look Feel Perform Goals
15:04 How Core Muscles Work
20:26 Stability and Anti Movement
24:00 Do Abs Need Daily Training
29:12 Spinal Safety and Crunches
31:37 Sponsor Eight Sleep
33:08 Testing Core Strength
41:42 Interpreting Test Results
47:02 Choosing Core Exercises
50:18 Isolation vs Compound Core
52:31 Contraction Intensity Rules
53:23 Size Principle Explained
56:16 Loading the Core Safely
1:00:14 Core Moves by Pattern
1:06:35 Program by Muscle Groups
1:08:01 Abs for Aesthetics
1:15:47 Aesthetic Programming Split
1:18:49 Core for Performance
1:21:15 Core for Back Health
1:24:17 Sample Week Template
1:29:22 Five Step Progression
1:35:54 Exercise Order Priorities
1:36:56 Rapid Fire Q and Belts
1:42:35 Final Wrap and Support

Includes paid partnerships.

[Andy Galpin, PhD @DrAndyGalpin]

See you in a few days.

Sincerely appreciate all of you who rock with me on this project.

https://t.co/V0djvtvMT5

[David Senra @davidsenra]

My conversation with Tony Xu (@t_xu), co-founder & CEO of @DoorDash.

0:00 DoorDash MVP in 43 Minutes
1:39 How Delivery Worked in 2013
3:17 Small Business Roots and Insight
5:48 Why Restaurants First
8:24 Palo Alto vs San Francisco
11:03 Early Customers and Unit Economics
15:22 YC Summer Three Questions
19:50 The Hidden Complexity of Delivery
22:02 Competing on Invisible Details
23:54 Chaos Data and Experiment Loops
30:58 Trust Reset Every Day
31:30 Stanford Game Meltdown and Refunds
34:41 Scaling Through Experiments
37:37 Customer North Star Metrics
40:10 CEO Customer Support Habit
42:55 Anecdotes Versus Data
46:52 Eternal Mission Local Economies
50:09 Turning Data Into Merchant Growth
59:12 New Products Beyond Delivery
1:01:14 Autonomous Delivery Strategy
1:05:06 Hiring Rhodes Scholar Navy SEALs
1:12:46 Driver Switch Experiment
1:13:42 Who Delivers and Why
1:15:33 Hiring for Action
1:18:07 Earned Secrets via Experiments
1:20:01 Money vs Problem Solving
1:21:18 Thousand Days of Hell
1:26:04 Staying Sane as CEO
1:30:07 Ignore the Stock Price
1:31:44 Two Operating Systems
1:35:17 Internal Venture Stage Gates
1:38:17 Learning from Founder Peers
1:42:29 Jiu Jitsu Lessons
1:44:37 AI Changes the Loop
1:47:01 Data Needs Action
1:48:24 Closing Thoughts

Includes paid partnerships.

[David Senra @davidsenra]

Tony Xu. DoorDash.

Tomorrow. March 29, 2026.

Available everywhere you get podcasts.

@t_xu @doordash

[David Senra @davidsenra]

My conversation with @EricJorgenson, author of The Book of Elon (@elonmusk).

0:00 Book Reveal
0:39 Build Useful Things
2:19 Engineering Talent Edge
4:26 Wired for War
6:47 Tip of the Spear
8:47 Burn the Boats
13:13 Facing Fear
15:16 Origin Story Myths
18:19 Know Business A to Z
22:17 Simplify and Fail Fast
25:35 Reality and Physics
28:18 The Algorithm Begins
30:34 Delete and Simplify
34:25 Starlink War Room
36:52 Repetition as OS
38:18 Step Three Simplify Optimize
38:43 Question Every Requirement
39:13 Tesla Battery Pack Delete
40:43 Repetition Installs Ideas
42:02 Step Four Accelerate
43:26 Design Org for Speed
46:06 Step Five Automate
46:29 Control and Clean Sheet
48:54 Vertical Integration and Costs
50:47 SpaceX Incentives and Mars
57:11 Frontier Unlocks Starlink
1:00:26 Time as True Currency
1:03:58 Speed Triage and Bottlenecks
1:10:11 Internalized Responsibility
1:12:56 Avoid Serialized Dependencies
1:14:31 Aligning the Team
1:15:07 Time Is the Constraint
1:16:00 One Metric Focus
1:18:03 Directional Predictions
1:19:06 We Must Make Stuff
1:25:39 Manufacturing as Moat
1:26:23 Speed and Direct to Customer
1:28:41 SpaceX Feasibility Study
1:33:07 Edge of Sanity Leadership
1:37:10 Bottlenecks and Integration
1:40:01 Design and Simplify
1:45:15 Catch the Rocket
1:48:14 Capitalism and Closing

Includes paid partnerships.

[Scicomm Media @scicomm]

Tomorrow's Huberman Lab episode is with Dr. Rhonda Patrick, PhD (@foundmyfitness), a biomedical scientist and science educator known for making complex health research accessible and actionable.

Dr. Patrick and @hubermanlab discuss the exercise, nutrition and lifestyle practices most strongly linked to better health and lower disease risk, how fasting and specific training strategies affect cardiometabolic health, visceral fat and cancer risk, and what the research says about supplements ranging from omega-3s and creatine to specialized compounds like BPC-157 and NMN.

[David Senra @davidsenra]

My conversation with Marc Andreessen (@pmarca), co-founder of @a16z and Netscape.

0:00 Caffeine Heart Scare
0:56 Zero Introspection Mindset
3:24 Psychedelics and Founders
4:54 Motivation Beyond Happiness
7:18 Tech as Progress Engine
10:27 Founders Versus Managers
20:01 HP Intel Founder Legacy
21:32 Why Start the Firm
24:14 Venture Barbell Theory
28:57 JP Morgan Boutique Banking
30:02 Religion Split Wall Street
30:41 Barbell of Banking
31:42 Allen & Company Model
33:16 Planning the VC Firm
33:45 CAA Playbook Lessons
36:49 First Principles vs. Status Quo
39:03 Scaling Venture Capital
40:37 Private Equity and Mad Men
42:52 Valley Shifts to Full Stack
45:59 Meeting Jim Clark
48:53 Founder vs. Manager at SGI
54:20 Recruiting Dinner Story
56:58 Starting the Next Company
57:57 Nintendo Online Gamble
58:33 Building Mosaic Browser
59:45 NSFnet Commercial Ban
1:01:28 Eternal September Shift
1:03:11 Spam and Web Controversy
1:04:49 Mosaic Tech Support Flood
1:07:49 Netscape Business Model
1:09:05 Early Internet Skepticism
1:11:15 Moral Panic Pattern
1:13:08 Bicycle Face Story
1:14:48 Music Panic Examples
1:18:12 Lessons from Jim Clark
1:19:36 Clark Versus Barksdale
1:21:22 Tesla Versus Edison
1:23:00 Edison Digression Setup
1:23:13 AI Forecasting Myths
1:23:43 Edison Phonograph Lesson
1:25:11 Netscape Two Jims
1:29:11 Bottling Innovation
1:31:44 Elon Management Code
1:32:24 IBM Big Gray Cloud
1:37:12 Engineer First Truth
1:38:28 Bottlenecks and Speed
1:42:46 Milli Elon Metric
1:47:20 Starlink Side Project
1:49:10 Closing

Includes paid partnerships.

[David Senra @davidsenra]

My conversation with @brian_armstrong, co-founder and CEO of @coinbase and @newlimit.

0:00 Crypto Power in DC
0:25 Market Structure Clarity
1:39 SEC Lawfare Origins
5:49 Suing the Regulator
9:09 Winning the SEC Case
11:11 Long Term Founder Mindset
12:20 Autism and Focus
15:04 Mission First Company Culture
21:10 Rebuilding From Scratch
23:05 Follow Your Nose
25:20 From Side Hustles to Coinbase
30:07 Argentina and Bitcoin Spark
32:33 Airbnb to Coinbase Nights
36:25 Finding a Co-founder
37:35 YC Without a Co-founder
38:41 Finding the Perfect Partner
40:18 Losing Money Per Trade
41:23 Support Backlog Chaos
43:29 Banking and Compliance Gauntlet
47:47 Raising Fast to Survive
51:36 Mission Values and Inspiration
57:54 Hiring for Spikes
1:02:14 Centralized vs Decentralized
1:05:51 From Bitcoin Wedge to Super App
1:07:59 How Coinbase Runs Today
1:11:00 Decision Speed and Risk
1:12:43 Internal Venture Bets
1:14:46 Funding Ideas Internally
1:15:18 Coinbase Marketing Experiments
1:16:56 Internet Native Shareholder Updates
1:21:58 Media Diet and Going Direct
1:26:47 Building a New Industry
1:31:44 Starting New Limit Longevity
1:36:17 CEO Stress and Routines
1:40:59 AI Agents at Coinbase
1:44:35 Base App Explained
1:46:47 Other Bets and SEZs
1:49:21 Closing Thanks

Includes paid partnerships.

[David Senra @davidsenra]

My conversation with @JasonFried, co-founder of @37signals.

0:00 Build Products for Yourself
1:40 Low Costs, Small Company, Enough Customers
3:06 Your Only Competition Is Your Costs
5:25 How 37signals Stays Lean
9:43 Rewriting Basecamp & Fighting Software Bloat
13:42 Why "Enough" Beats Growth
17:44 Product People vs. Business Shells
22:41 The "So What?" Mindset
27:45 Staying Close to Customers
34:43 The Reward for Good Work Is More Work
39:57 Six-Week Horizons & Compounding Decisions
45:20 Anti-Fragile Business With Tiny Units
50:55 Galápagos Product Design
52:44 Radical Authenticity Over Marketing Tricks
1:27:39 Rick Rubin & Intuition-Driven Building
1:42:25 Lightning in a Bottle & Knowing When to Stop
1:50:29 Defining Success: Pride in the Work
1:53:58 Independence Through Profitability
1:59:23 When Tech Adds Friction Instead of Value
2:04:11 Ruthless Editing & What Never Changes
2:08:14 Longevity as the Moat
2:17:28 Building by Intuition

Includes paid partnerships.

[Scicomm Media @scicomm]

Tomorrow’s Huberman Lab episode is with Dr. Lauren Colenso-Semple (@drlaurencs1), PhD, an expert in strength training, muscle building and nutrition.

Dr. Colenso-Semple and @hubermanlab discuss the most effective resistance and cardiovascular training programs for women, including program design, exercise selection, sets, reps and rest periods, how menstrual cycles, menopause and birth control impact fitness outcomes, and dispel common myths about women’s training, fasting, cortisol and supplementation.

[David Senra @davidsenra]

My conversation with Jimmy Iovine (@jimmyiovine_), co-founder of @Interscope Records & @BeatsbyDre.

0:00 The Corny World of Fame
0:54 The Impact of Social Media on Fame
1:27 Chasing Greatness: Personal Reflections
2:10 Technological Shifts in the Music Industry
3:24 The Streaming Service Dilemma
5:34 The Artist's Perspective on Streaming
6:39 Early Career and Influences
9:40 The Importance of Humility
11:19 Working with the Best: A Career Retrospective
13:07 The Role of Brutal Honesty
15:00 Navigating the Music Industry
33:50 The Birth of Beats by Dre
46:14 The Music Industry's Customer Problem
46:44 Vertically Integrating Culture and Fashion
47:13 Building Beats: From Music Videos to Headphones
48:03 Marketing is Empathy
50:28 The Journey of Beats Music
59:09 The Future of the Music Industry with AI
1:14:40 The Bend in the Pipe: Harnessing Fear and Obsession
1:29:12 Comparing Work Approaches with Dr. Dre
1:30:50 The Tortured Path to Success
1:32:41 Balancing Happiness and Ambition
1:35:22 The Importance of Peace and Therapy
1:49:30 Learning from Legends
1:55:57 The Influence of Bono and Dre
2:00:15 California Dreams and Career Milestones
2:07:20 Final Thoughts and Reflections

Includes paid partnerships.