Postdoc @ChildrensNatl - adoptive T cell therapies for pediatric solid tumors. PhDone! @ChiappinelliLab @GWCancer @GWSMHS @GW_IBS My tweets are my own!
Excited to share my first author manuscript in #JITC@jitcancer from my PhD lab @ChiappinelliLab. Thank you also to all co-authors for your contributions: @rrwalker_ and many (Twitter-less) others. https://t.co/pUs9TNNt8y🧵1/7
BREAKING: GW announced a final agreement with UHS over the MFA which would transfer clinical operations to a new non-profit physician group — the Capital Medical Group — and shift financial responsibility away from the University. Story TK
Just spent entire day reading/reviewing a 100 page article (incl. supplemental data). AI could have been used by journal to pre-screen & make the same decision I did > in fraction of time. So why don't journals do this? Because my time, + those of the 2-4 other experts, is "free"
🚨NEW FDA Draft Guidance Safety Assessment of Genome Editing in Human Gene Therapy Products Using Next-Generation Sequencing #FDA#Regulatory#geneediting#genetherapy
Top 5 Takeaways -
1) NGS becomes the regulatory backbone for genome editing safety
2) FDA expects a layered, redundant approach to off-target assessment
3) Low-frequency events matter and must be detectable
4) Patient genetics is now explicitly part of risk assessment
5) Genome integrity (translocations) is no longer optional for DSB-based gene editing systems
https://t.co/28QKQPFtLb
Tree pollen spiked again with onset of warmer temperatures. 🤧 The most recent 24-hour report from Tuesday morning indicated it was very high at 2,152 grains per cubic meter of air. Tree pollen counts were up about 550 since Monday’s count and among the most significant counts so far this season.
At the current tree pollen level, almost all allergy sufferers will experience symptoms, and some individuals will have severe symptoms.
Oak is the biggest contributor, as it tends to be around here. Sycamore, mulberry and pine are also offering up a lot of pollen.
The report for the 24 hours ending April 3 was very high at 3,193 grains per cubic meter of air and may have been the peak, unless it happens in coming days. Oak catkins — the snake-shaped flower clusters that deliver pollen — have heavily dropped from trees since that earlier warm spell, although some remain.
Just met with a PI at UCSC who also confirmed this. She will not preprint new work because she was told by editors it would hurt her chances. Not good for science!
I’ve also used AI LLM agents (mostly chatGPT thus far) to help me explore datasets and help identify artifacts (I did have to do a lot of prompting). I think this greatly enhances robustness of any analysis. Definitely one of my favorite use cases thus far!
I spun up a fresh claude code session to test this! I fed my coding agent the original dataset that made us think something was off and monitored to see how much prompting the agent would need before it became similarly suspicious. (1/n)
Single-cell spatial T cell receptor profiling can reveal the distribution and gene expression profile of individual T cells in human tumors, which could inform improved #immunotherapies.
Learn more in Science #Immunology: https://t.co/m9JlaCpCgP
The way our immune cells age differs substantially by sex, from single-cell analysis of ~1,000 people. Implications for propensity for autoimmune diseases (women), vulnerability to cancer (men), immunosenescence and inflammaging @NatureAging
https://t.co/GjcuZ8luNM
If you use 10x Flex for single-cell profiling, check out our new paper that might have implications for your experimental design and analysis.
We introduce probe set barcode as a major source of technical variation in probe-based single-cell data.
Just updated my HHMI Gilliam Fellowship application guide for the 2026 competition, which brings major program changes.
Int'l PhD students can now apply. MD-PhDs are eligible. & a new postdoc pathway that can extend HHMI support up to 7 years total.
https://t.co/BSQ11pBpfW
The TIGIT catastrophe‼️
30 agents
220 trials
~50,000 patients
>$3B+ invested
0 approvals.
This is herding in drug development.
In BMJ Oncol we examine why it happens, the hidden costs, and what needs to change.
It’s already happening again in ADCs...
🔗:https://t.co/dvbS49jGkF
Typing "hello" in Claude currently costs 2% of your ENTIRE account usage...
If you keep getting screwed by Claude usage limits, save this.
How to reduce your Claude token usage by 50%+ (pro tips):
A one minute primer on how #AutoSpectral improves spectral flow cytometry unmixing by using per-cell calculation of autofluroscence spectra.
Use our R package and get higher quality spectral data, easy as that!
https://t.co/BG3DVIM13r