Sebastian Roemer-Cassiano

@sebroemer.bsky.social
Clinician Scientist at Franzmeier-Lab ISD; Resident Physician in Neurology at LMU Munich; Max Planck School of Cognition PhD

[Shaoshi Zhang @ZShaoshi]

1/11 Our new paper is out in Alzheimer’s & Dementia! 🚨
Does cortical excitation–inhibition (E/I) imbalance link amyloid pathophysiology to memory? We tested this in non-demented older adults (cognitively normal + MCI) across two independent cohorts. 🧵👇
https://t.co/VxphBFS4iC

[Sebastian Roemer-Cassiano @SebRoemer]

Many thanks to the @HAIconference committee and Maria Carrillo for recognizing the importance of our work with the HAI Travel Fellowship and the AAIC/ISTAART Fellowship—my surprise is clearly written all over my face. An amazing finale to a very interesting conference

[HumanAmyloidImaging @HAIconference]

And applause for our HAI travel scholarships and the AAIC/ISTAART fellowship winners!

[Nico Franzmeier @nfranzme]

Out now in Brain: Our new study co-led by @matbrendel shows that tau deposits in Alzheimer’s disease not affect gray matter but also drive degeneration of connected white matter tracts, offering mechanistic insight into how tau disrupts brain networks
https://t.co/gr3q2i2jup

[Sebastian Roemer-Cassiano @SebRoemer]

2/ and thanks again to our FRS team for the great talks and organization @fislarissa @HeidiJacobsLab @anne_maass Arnold Bakker, Yu Xiao, Jessica Peter, Bill Jagust and @nfranzme

[Sebastian Roemer-Cassiano @SebRoemer]

1/ What a session. I believe I saw people sleeping in front of the door to get a seat in the first row when doors opened!
Thanks to #AAIC25 for giving us the opportunity to organize this FRS, and thanks to everyone who came and participated in the cool discussion!

[Sebastian Roemer-Cassiano @SebRoemer]

@fislarissa @HeidiJacobsLab @anne_maass 3/3: Also don’t miss our other FRS on tau heterogeneity in AD on Mon., July 28, 2:00 PM, chaired by @nfranzme and @_JakeVogel_, with talks by Zeyu Zhu and Anna Steward, and all the great posters of our lab by Madleen Klonowski, Lukas Frontzkowski, Fabian Hirsch and Amir Dehsarvi.

[Sebastian Roemer-Cassiano @SebRoemer]

1/3: Whether you are in Toronto to attend #AAIC25 or visiting the birthplace of Neil Young and Drake – make sure to not miss our Symposium on “Network alterations and aberrant neuronal activity in Alzheimer's disease” on Wed., July 30, 2:00 PM

[Sebastian Roemer-Cassiano @SebRoemer]

2/3: Innovative topics by Yu Xiao, @fislarissa, @HeidiJacobsLab, Jessica Peter, Arnold Bakker and myself are awaiting you, chaired by @anne_maass and Bill Jagust. It was great fun organising this FRS and I am looking forward to some interesting discussions.

[Sebastian Roemer-Cassiano @SebRoemer]

Always great pleasure to work with you @ZShaoshi and congrats again to you, @csabaorban, @Leon_Oo1 and @bttyeo for this very cool study!! I hope ours is next 🤞🏻

[Shaoshi Zhang @ZShaoshi]

Special shoutout to @csabaorban and @Leon_Oo1 for co-leading this work! Huge thanks to @nfranzme, @SebRoemer and all our collaborators for contributing their invaluable datasets! Truly an amazing joint effort!

[Nico Franzmeier @nfranzme]

Very happy to share our 2nd paper today, led by Lukas Frontzkowski: We developed a novel data driven reference region for PI-2620 PET tailored to assess 4R tauopathies, improving i) PSP vs. control separation and ii) PET associations with clinical scores
https://t.co/WRsD9EdSIm

[Nico Franzmeier @nfranzme]

Happy to share new work by Carla Palleis in @movedisorder, showing that brain networks route neurodegeneration patterns in PSP
=> This suggests that grey matter atrophy expands across connected brain regions, potentially following tau accumulation in PSP

https://t.co/PrRkE8XzRb

[Emma Coomans @EmmaCoomans]

So excited and honored to be invited to present the opening plenary at #AIC2025 this year in Toronto! 🧠

🙏 I would be very grateful if you could help me gather the most inspiring papers (including your own!) of the past year by completing this survey: https://t.co/wjzdmNmH9f

[Sebastian Roemer-Cassiano @SebRoemer]

@EmmaCoomans Congrats Emma, looking forward to it!

[Nico Franzmeier @nfranzme]

Excited to share our new work in Molecular Neurodegeneration, showing that α-synuclein co-pathology is common in Alzheimer’s and accelerates amyloid-related tau accumulation, supporting its role as a tau co-aggregation factor.

https://t.co/VdFHnSY2xJ

[Sebastian Roemer-Cassiano @SebRoemer]

Many thanks to the ADPD2025 committee for recognizing our work with @nfranzme on the effects of amyloid-induced hyperconnectivity on tau spreading! If you are enjoying a Gösser Radler and a Sacher Torte in Vienna, don't miss ADPD and my talk in Hall C at 10:00 on Wed 02.04.25

[@BrainComms @braincomms]

de Bruin et al. report that traumatic brain injury alters amyloid-β and tau deposition, with increased accumulation in fronto-parietal regions, & disrupts amyloid-tau coupling. Please read at: https://t.co/LG3ffdKRvh @deBruin_Hannah @Colin__Groot @RikOssenkoppele @nfranzme

[Sebastian Roemer-Cassiano @SebRoemer]

Thanks to @NatRevNeurol for highlighting our latest work on amyloid-induced hyperconnectivity and how it promotes tau spread! Can’t wait for the next studies to describe this novel mechanism more in detail and maybe even tackle it therapeutically!? Exciting times

[Nat Rev Neurology @NatRevNeurol]

Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer’s disease | Science Translational Medicine https://t.co/CzMNkeJXRZ

[Science Translational Medicine @ScienceTM]

What’s the relationship between #AmyloidBeta and tau protein?

New research involving #AlzheimersDisease patient PET and fMRI data reveals amyloid-beta may drive tau spread through hyperconnectivity between vulnerable brain regions. @nfranzme @SebRoemer https://t.co/8kmzKOkC5s

[Sebastian Roemer-Cassiano @SebRoemer]

Nice to see @alzforum covering our most recent article in @ScienceTM and highlighting its importance for future lines of research and therapy! Special thanks @DavidJonesBrain and Tarick Pascoal for the great comments on our work!

https://t.co/t5fCOY5L1Y

[Science Translational Medicine @ScienceTM]

This week's issue of #ScienceTranslationalMedicine is out now!

A new transplant protocol extends the survival of heart transplants in large animals, researchers explore emerging horizons in the use of hypoxia to treat chronic conditions, and more. https://t.co/emvn74CdpR