Sex Differences in the Immune System

Biennial conference on sex differences in the immune system organised by @WhiteheadInst & @tcddublin. Next meeting: TBC

[Sex Differences in the Immune System @SexDiffImmuno]

Interested in following Sex Differences in the Immune System 2024 but can't make it to Dublin? We have a virtual registration option that will allow participants to view live-stream sessions.

https://t.co/aCz38cpLQa

[Page Lab @PageLabXY]

https://t.co/SpShYymGLh

[BogunovicLab @BogunovicLab]

📢 Register for the 2025 Henry Kunkel Society Meeting on "Genes & Immunity" and join us in Belgrade from April 10-12, 2025. https://t.co/Y9EZEiSzPH
#HKS2025 #Immunology 🧬🔬

[Bruno Lemaitre @BrunoLemaitre3]

We are recruiting one postdoc and one PhD student to join our lab on #Drosophila #innate immunity in Lausanne (Switzerland). https://t.co/NReBv3W7UR

[Dr Rachel Mcloughlin @McLoughlin_Lab]

We are hiring!!! If you are interested in #gdTcells or #Staph this is the position for you!! Post-Doctoral Research Fellow in Immunology at Trinity College Dublin, The University of Dublin https://t.co/tKtagaEdZM

[Petter Brodin @BrodinPetter]

Journal of Human Immunity is coming! Excited to be a part of this and support great studies of the unique immune system of human beings: https://t.co/GAHTmWc3zH

[Diana Dou @DianaRDou]

So proud to have been a part of this amazing team and community! Couldn't have asked for a more supportive postdoc training environment than with @HowardYChang @StanfordMed. Let's keep pushing the field together! #Autoimmunity #WomensHealth #AcademicTwitter #theJourneyContinues

[School of Medicine, Trinity College Dublin @TrinityMed1]

Endogenous steroid hormone assessment is essential for clinical practice. These hormones are typically measured in blood. This important review @linazgaga @tcddublin finds that lack of standardization is limiting clinical utility @TrinityResearch https://t.co/od7NiTr1JU

[Elisabet Stener-Victorin Lab @ElisabetStener]

Time to register ➡️

[Waggoner Lab @LabWaggoner]

TLR7 and TLR8 escape X-inactivation in pDCs of patients with systemic sclerosis due to decreased expression of XCI machinery, increasing pDC subclusters with high IFN-I signature @JExpMed @CharlesGuery Barrat
https://t.co/cjCahDGTXi

[Camila Rosat Consiglio @consiglio_cr]

Are you an #immunologist?

Do you have expertise in molecular and cellular biology?

Do you want to investigate why men and women mount immune responses differently?

Join us as a #PostDoc in #SystemsImmunology and explore mechanisms of #SexDifferences in #Immunity!

See below

[Journal of Experimental Medicine @JExpMed]

Du, Faz-Lopez, @CharlesGuery @Univ_Toulouse, Barrat @HSpecialSurgery et al. describe that TLR7 and TLR8 escape X-chromosome inactivation in plasmacytoid DCs of patients with systemic sclerosis. https://t.co/nSRRGO9dvZ

#InnateImmunity #inflammation #Autoimmunity

[Waggoner Lab @LabWaggoner]

A landscape of X-inactivation during human T cell development
https://t.co/9kAelFRXaX
@theNestorLab

[Martin Picard @MitoPsychoBio]

If we look at thousands of proteins (i.e., signals) in the human blood, the protein most associated with chronic physical and mental illnesses is the **same protein** as the top marker for mitochondrial diseases: GDF15

When mitochondria cannot flux energy properly, the cell makes and secretes GDF15 in the blood to alert other cells

Some highlight by Cynthia Liu in our group:
- GDF15 is the top predictor for most diseases

- GDF15 associated with diabetes is among the most significant protein-prevalent disease associations
Based on p-value, GDF15 was most significantly associated with disease.

- “GDF15 was associated with the most diseases, containing 205 prevalent and 397 incident diseases, generally acting as a risk factor except for three incident diseases (respiratory diseases affecting the interstitium, disorders of magnesium metabolism, and peripheral artery disease).”

- “GDF15, similar to its high ranking with protein-disease pleiotropy, ranked second for protein-trait associations, boasting a substantial 428 associations.”Significant associations with many lipid metabolite markers.

- Mental disorders like anxiety disorders, depression, and mood disorders, along with mental health-related traits, also exhibited substantial proteomic signatures including elevated GDF15

- “The fluid intelligence score and various types of dementia shared significant proteins such as NEFL and GDF15 (Figure 2G)”

- “GDF15, the protein with pleiotropic effects, was causally associated with several autoimmune diseases, including ulcerative colitis and rheumatoid arthritis (Figure 6B).”

Data from >53,000 people in the UK Biobank

Full paper here:
https://t.co/F3dn16E0t2

Resource to explore your favorite protein or disease/trait of interest: https://t.co/BjpilkdtHW

[Camila Rosat Consiglio @consiglio_cr]

Join our #SystemsImmunology Lab (Lund University, Sweden) as a #Postdoctoral Fellow!

🔬Investigate sex hormone regulation of human immune function using CRISPR, transcriptomics, and immunophenotyping. Fully funded 2-year position (more info attached).

🗓️Apply by Jan 6, 2025

[Lydia Lynch @lynchielydia]

Language model-guided discovery of x-metabolites ! Amazing discovery and tool by @skinniderlab @Ludwig_Cancer

[Bruno Ramos-Molina, PhD @Brunorm84]

Adipose tissue retains an epigenetic memory of #obesity after weight loss @Nature https://t.co/8eG2v5jDYj

[Waggoner Lab @LabWaggoner]

SLE monocytes absorb mitochondrial nucleic-acid-containing red blood cells that engage cGAS/STING, RIG-I, MDA5, NLRP3 for unconventional IL-1β and IFN-I release @ImmunityCP @JefferiesLab @ADorfleutner
https://t.co/WJTBjUI7wg
https://t.co/CeuWSh89Sv

[Jonathan Kagan @jkagan1]

Different flavors of interferons in the lungs. Learn more in this authoritative review by Zanoni et al. Must read!
@Lo_Zanzi @BostonChildrens
@harvardmed
https://t.co/jjARbrimDD

[Angela Jones @_AngelaJones]

So excited to share some of our work TOMORROW on sex differences in gene expression and disease at #ASHG24! 🧬 👩‍🔬

[Waggoner Lab @LabWaggoner]

RSV infection in 3wo mice induces persistent changes in mucosal NK and T cell profiles that are more pronounced in males and that may break mucosal immune tolerance leading to good allergy or gut inflammation @StellaLiong_ @noxbiology
https://t.co/VFVO1seaOt