Dustin Shackleton

AP/CP Pathologist, Hospital Lab Medical Director | GI/Liver enthusiast | Basketball Dad 🏀 ☕️ (opinions my own; All pt data modified)

[Dustin Shackleton @ShackletonMD]

Some cancers almost seem to crawl across the slide. 🔬 #lifeofapathologist #lungcancer

[Aakash Gupta @aakashgupta]

This isn’t a random scientist who got lucky.

Mariano Barbacid discovered the first human oncogene in 1982. He isolated H-RAS from bladder cancer cells and proved a single point mutation could trigger cancer. That finding launched the entire field of molecular oncology.

KRAS mutations cause 90% of pancreatic cancers. For 43 years, oncologists called KRAS “undruggable” because the protein had no obvious binding pocket. Barbacid spent the last decade using genetically engineered mice to systematically test every node in the KRAS signaling pathway, looking for combinations that would work without killing the patient.

The triple therapy blocks KRAS three ways at once: the main growth signal, the escape routes through EGFR and HER2, and the stress-response backup through STAT3. Cut the engine, seal the exits, disable the emergency system. Tumors vanished in mice and didn’t return for 200+ days after treatment stopped.

Pancreatic cancer has a 13% five-year survival rate. 8% for the ductal adenocarcinoma type this therapy targets. Most patients live one year after diagnosis.

The catch: this is preclinical. Human trials are 3+ years away. One of the drugs, RMC-6236, might get approved this year, but the full triple combination has regulatory hurdles.

Still. The man who discovered human oncogenes in 1982 may have just figured out how to eliminate the cancer those genes cause. That’s a 43-year arc from first principles to potential cure. Science rarely works this clean.

[Dustin Shackleton @ShackletonMD]

RIP #CatherineOHara another generational movie mom down.

Can someone get a status check on Diane Wiest?

[Dustin Shackleton @ShackletonMD]

Please be safe if you decide to…mix and mingle in a jingling beat…this Holiday.

[Aswathy Menon @dr_amenona]

Hello everyone! Shall we demystify another molecular entity together? It may be a little dense but I hope it gets the message across! Lets start with a couple of questions 1/ #PathTwitter #IHCpath #Pathresidents #Molpath

[Medical Lab Lady Gill @MedicalLabLadyG]

📢CALLING ALL #MedicalLab students👩‍🔬🧑‍🔬🔬💉 (MLT, MLS, and Phlebotomy)

Update social media account profiles to open to employment opportunities & grad date!🗓🧑‍🎓👩‍🎓

Start NOW to beat the rush of new grads!!!!! Employers are standing by!!!!
@ASCP_Chicago @ASCLS

[Sanjay Mukhopadhyay @smlungpathguy]

Smoking-Related Interstitial Fibrosis (SRIF) in Patients Presenting With Diffuse Parenchymal Lung Disease | American Journal of Clinical Pathology | Oxford Academic https://t.co/htSDBEBR0i

[Sheldon Kernodle @amigoshel]

PLEASE SHARE! 🚨 My family is asking for your help. Please email or call the Moscow Police Department tip lines in this post with any information you have that could help solve this tragic crime that has devastated our families.

📧 [email protected]
📞 [phone]

[Dustin Shackleton @ShackletonMD]

@JohnOmaha16 @AshleyGWinter So that they do not get cancer caused by HPV. Cancer is worse and HARDER to treat than emesis. (Edited)

[Swathi Prabhu, MD @Swathiprabhu5]

Platelets with numerous projections on its surface🧐

[Dustin Shackleton @ShackletonMD]

@appyjumpindaze Must be switched right? $88K in car loans & $170K student loans? If so, I’m actually jealous. 🙄

[Ankur Sangoi @slusagar]

#PathTip #GUpath #LPpath:
when screening prostate biopsies at low power &👁️ small glands traversing from one side of the core to the other ("glands crossing the street), definitely🛑stop🛑 & go down on high power!

[Dustin Shackleton @ShackletonMD]

@KylieInCali84 @JanetGraceMusic I’d be curious what this new provider’s credentials are. Was this a medical doctor?

[Kobi Simmons @JordanKobi]

A Bottle of water can be .50 cents at a supermarket. $2 at the gym. $3 at the movies and $6 on a plane. Same water. Only thing that changed its value was the place..So the next time you feel your worth is nothing, maybe you’re at the wrong place💯

[Steve · Millionaire Habits @SteveOnSpeed]

About 90% of your early career boils down to your ability to interview. Most young people suck at it, and it shows.

Want to be a millionaire? Master the art of interviewing. You'll get the job every time.

Go undefeated by avoiding these 9 insanely common mistakes.

[ASCO @ASCO]

News from #ASCOPlenarySeries August session via @ASCOPost: Study Shows Germline Testing May Be Warranted for All Patients With Lung Cancer https://t.co/1sjoVqhhIV #lcsm #germlinetesting

[BST Path Education @PathBst]

Another bread and butter case with fun #radpathcorrelation. Young adult with destructive sternal lesion and mediastinal lymphadenopathy. What immunostains do you want and what stage is this?
#BSTpatheducation

[Dustin Shackleton @ShackletonMD]

@kellypat123 @AmyHDeekenMD This is wonderful.

[Dustin Shackleton @ShackletonMD]

👇This!

[Jocelyn J. Fitzgerald MD @jjfitzgeraldMD]

IF YOU SEE A YOUNG PATIENT WITH A UTERUS AND GI SYMPTOMS AND DEBILITATING PELVIC PAIN AND ALL OF HER WORKUP HAS BEEN NEGATIVE SHE HAS ENDOMETRIOSIS UNTIL PROVEN OTHERWISE

[womenshoopsworld @hoopism]

Two games tomorrow: Storm at Mystics, 12 p.m. ET, and Wings at Dream, 7:30 p.m. ET.