Shawn Shortill

PhD, Medical Genetics from @UBC @CMMT_UBC 🧬 Investigating synthetic lethality in DNA repair pathways @BCCancer 🏥 Opinions are mine, RT/like ≠ endorse

[Shawn Shortill @ShawnShortill]

I’m very excited to share that my PhD work is now published @eLife! We used a combination of genetics, cell biology and biochemistry to identify a new endosomal complex in yeast, which we named VINE 🌿 Early access here: https://t.co/BUF7s3xYjL. (1/n).

[Shawn Shortill @ShawnShortill]

@CellsAndProts @CIHR_IRSC Fantastic! Congrats to you and the whole Mayor lab team!

[Diego del Alamo @DdelAlamo]

"Reliable protein-protein docking with AlphaFold, Rosetta and replica-exchange"

Some promising results on antibody-antigen complex prediction

https://t.co/vlUszvFCwB

[Shawn Shortill @ShawnShortill]

Interesting paper, awesome name for a shortened BAR domain!

[Echard Lab, Pasteur Institute, Paris @TMDCLab_Pasteur]

MiniBAR has a unique truncated BAR domain, is a dual Rac / Rab #GTPases effector and controls both actin cytoskeleton and membrane trafficking in ciliogenesis.

#RabGTPases #RhoGTPases #actin #myosin #membranetraffic #ciliopathies #zebrafish #cilia

[Shawn Shortill @ShawnShortill]

Yeast friends—this is an interesting approach to getting around stubborn, tag-intolerant proteins for imaging studies

[Joachim Goedhart @joachimgoedhart]

"Here, we successfully use LIVE-PAINT to image yeast membrane proteins that do not tolerate the direct fusion of a fluorescent protein by using peptide tags as short as 5-residues"
https://t.co/GmbdPvD9lR

[Hannes Maib @hannes_maib]

Finally the community has a reliable, specific and high affinity probe to detect PI(3,5)P2 ! I am very excited about the new insights that this new tool will deliver about how this rare phospholipid controls diverse cellular events. Been great working on this with @jasonkinglab

[Shawn Shortill @ShawnShortill]

@PerryHo21793268 @uvic @UVicBCMB @Camosun @SuferDrude @pcstirling @HieterLab @UBC @conibear_liz For my next steps, I’ll be joining @pcstirling and @HieterLab to leverage synthetic lethality in DNA repair pathways for the treatment of various cancers. Stay tuned for more! 4/4.

[Shawn Shortill @ShawnShortill]

I’m excited to share that after five amazing years with @conibear_liz and @UBC @CMMT_UBC, I have defended my doctoral dissertation and finished my PhD in Medical Genetics.

We made some exciting discoveries over the years, and published papers that I’m truly proud of. 1/n.

[Shawn Shortill @ShawnShortill]

@PerryHo21793268 @uvic @UVicBCMB @Camosun @SuferDrude @pcstirling @HieterLab @UBC Most of all, I want to thank @conibear_liz for being such an inspiring mentor and fiercely creative scientific role model. It was a privilege to work in the Conibear lab, and it wouldn’t be possible to synthesize all of the things I learned from Liz into a single tweet. (3/n).

[Arrowsmith Genetics @ArrowsmithGx]

Arrowsmith Genetics is excited to be in Round 3 of the New Ventures BC competition. Looking forward to meeting our mentors and other NVBC ventures. #NVBC2023 #BCtech #BCentrepreneurs

[Shawn Shortill @ShawnShortill]

A good perspective on the new changes @elife from a senior editor:

[Franklab_LNCC @LnccBrown]

as a long time senior editor for @eLife I (MJF) thought I'd weigh in. When I first heard about the plan in its initial conception, I had my reservations for many of the same reasons some of you articulating. I've changed my mind. I think it is worth a shot

[Shawn Shortill @ShawnShortill]

We have all (rightfully) complained about how flawed the current science publishing system is.

The @eLife team is now challenging this status quo by abandoning the traditional “accepted manuscript” title to instead publish everything that gets reviewed, along with an assessment.

[eLife - the journal @eLife]

Today, we’re introducing a new model that eliminates accept/reject decisions.

By publishing every paper with eLife reviews as a Reviewed Preprint, we plan to restore autonomy to authors, ensuring that they will be judged by what, not where, they publish. https://t.co/OAsiOVFStI

[Shawn Shortill @ShawnShortill]

Cool!

[Shawn Shortill @ShawnShortill]

Manuscript accepted!! 🕺🏼🍾 This was a large, multi-lab project and I’m happy to have contributed to its success. Stay tuned for yeast membrane contact sites, lipid biology and a first glimpse at the (very) complicated inner workings of a potential new lipid transport protein—Lec1

[Shawn Shortill @ShawnShortill]

Normalize bedroom genome assembly and annotation 🛏️🧬

[Kobor Lab @koborlab]

Come work with us - exciting opportunity to get in at the early stage and substantially contribute to shaping the future and development of a new interdisciplinary and ambitious research program @UBCmedicine @UBC @UBCAging

[Shawn Shortill @ShawnShortill]

Congratulations @SaketBagde! This is so exciting and well deserved

[Fromme Lab @Fromme_Lab]

Congratulations to our own @SaketBagde for winning the Spicer Young Investigator award!!!! 🎉🎉🎉 https://t.co/1PgHPa32wx

[Shawn Shortill @ShawnShortill]

@BiochemSean Congratulations, nice paper!

[UBC Medical Genetics Graduate Students Association @MEDGGSA]

Thank you Cheryl Bishop for all your years of service in Medical Genetics. You will be missed. We wish you a very happy retirement!

[Ivan Alcantara @ivancalcantara]

Prince Charles updating his email signature like PhD students after passing their candidacy exams