Sheldon Rowan

Scientist II and Assistant Professor, Tufts University Human Nutrition Research Center on Aging, Ophthalmology, Friedman School of Nutrition Science and Policy

[Sheldon Rowan @SheldonRowan]

https://t.co/JkL4dLR0Ye

[Sheldon Rowan @SheldonRowan]

The new OMB rule changes put every form of research at risk and turns peer-reviewed science into a political circus act. I was terrified learning about the changes and will be leaving public comment and contacting congress.

[Liz Millsaps Haigler @lizfungirl]

"What OMB is proposing is not a reform of grants management. It is a complete political control apparatus layered over every stage of the federal science funding lifecycle," former NIH program official Elizabeth Ginexi wrote on Substack.

https://t.co/wbEerWf6Ay

[Sheldon Rowan @SheldonRowan]

https://t.co/dxxwIALAEq

[News from Science @NewsfromScience]

Plants live off light, capturing its energy through photosynthesis to make food, but we lack the molecular machinery to do the same.

Now, a research team has tricked out lab-grown mouse and human cells with photosynthetic structures—not for nourishment, but to create a treatment for a common, painful condition called dry eye. https://t.co/MEeyGVxxoh

[Sholto David @addictedtoigno1]

Earlier this week I posted an example of a fake western blot provided by ThermoFisher to demonstrate the validity of a p53 antibody. I considered it an amusing curiosity. In fact ThermoFisher has systematically manipulated antibody validation data. Short Thread... 🧵

[Sheldon Rowan @SheldonRowan]

@YoniFreedhoff They don't even know that the visceral fat reduction was involved. Intramuscular adipose might be even more important for cognitive outcomes and would also reduce with long-term MeDi intervention. Eh, it was probably the glycemic improvements..

[Danny Arends @DannyArends]

Our paper in @Nature today 🥳 We tracked 6,438 mice from puberty to death and mapped the genetics of *when* you die, not just whether a gene associates with lifespan.

https://t.co/EoeexqJoHk

59 loci. Two decades of data. Thread 👇

#Longevity #Aging #Genetics #Healthspan

[Julia Belluz @juliaoftoronto]

What are GLP-1s actually doing?

In my latest for the @nytopinion, I explore how patients experience these drugs & why the story may be more complex than many assume.

https://t.co/hGaPI5v8BF

feat. insights from @DanielJDrucker @seeleyrj @BevTchangMD among many others #glp1

[Hedgie @HedgieMarkets]

🦔A researcher invented a fake eye condition called bixonimania, uploaded two obviously fraudulent papers about it to an academic server, and watched major AI systems present it as real medicine within weeks.
The fake papers thanked Starfleet Academy, cited funding from the Professor Sideshow Bob Foundation and the University of Fellowship of the Ring, and stated mid-paper that the entire thing was made up. Google's Gemini told users it was caused by blue light. Perplexity cited its prevalence at one in 90,000 people.

ChatGPT advised users whether their symptoms matched. The fake research was then cited in a peer-reviewed journal that only retracted it after Nature contacted the publisher.

My Take
The researcher made the papers as obviously fake as possible on purpose. The AI systems didn't catch it. Neither did the human researchers who cited it in real journals, which means people are feeding AI-generated references into their work without reading what they're actually citing.

I've covered the FDA using AI for drug review, the NYC hospital CEO ready to replace radiologists, and ChatGPT Health launching this year. All of that is happening in the same environment where a condition funded by a Simpsons character and endorsed by the crew of the Enterprise was being presented as emerging medical consensus. The people making these deployment decisions seem to believe the pipeline from research to AI to patient is more supervised than it actually is. This experiment suggests it isn't supervised much at all.

Hedgie🤗
https://t.co/8Kg8FOrgHW

[NASA Artemis @NASAArtemis]

Earthset.

The Artemis II crew captured this view of an Earthset on April 6, 2026, as they flew around the Moon. The image is reminiscent of the iconic Earthrise image taken by astronaut Bill Anders 58 years earlier as the Apollo 8 crew flew around the Moon.

[Eric Topol @EricTopol]

Will cell reprogramming with stem cell factors reverse aging? A pilot trial in eye disease will soon be the first test at the tissue level.
https://t.co/PnRf1gZNY3
Feature @Nature by @heidiledford @altos_labs @lifebiosciences

[Eleni Beli @belielen]

an exciting new #phd opportunity in collaboration with @CampagnoloLab funded by @fightforsightUK on #circadian coupling between #pericytes and #endothelial cells of the #retina https://t.co/a4iPGwbIt1

[Danny Saban @SabanLab]

So the question is not only: where do resident macrophages come from? It is also: when does self-maintenance become durable, and when does it fail to do so? That is the problem Establishment Kinetics is meant to solve. Full paper in Advances in Immunology https://t.co/JtcwezzZTB

[Lamming Lab @LammingLab]

Please enjoy the latest publication from our lab "Restriction of Individual Branched-Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice"

[Sheldon Rowan @SheldonRowan]

@LammingLab Awesome study! I also really appreciate the insights this work has in sex differences!

[IOVS Journal @ARVOiovs]

Malia Edwards et al from Wilmer Eye Institute @HopkinsMedicine describe choroidal vascular findings in a case of multifocal geographic atrophy using histology & immunohistochemistry & correlating the findings with multimodal clinical imaging @AMD_histo_lab
https://t.co/aMN8am3vYv

[Danny Saban @SabanLab]

We are excited to share that our team's paper is published in Immunity: "Resident tissue macrophages maintain intraocular pressure homeostasis."
This work grew out of a collaboration between glaucoma clinician-scientist Katy Liu MD PhD, glaucoma physiologist W. Daniel Stamer PhD, and immunologist Daniel Saban PhD, bringing together clinical, physiological, and immunological expertise to tackle a long-standing question: does the immune system directly regulate intraocular pressure?
The answer is yes.
https://t.co/RirTbsyeha
#Glaucoma #Immunology #ResidentMacrophages #Ophthalmology #Immunity #CellPress

https://t.co/y25dBZSAtm

[F. Perry Wilson, MD MSCE @fperrywilson]

"A daily multivitamin slows biological aging." That's the headline from a new Nature Medicine paper. From a randomized trial! But when you actually read the data, the vitamin is doing just about nothing. Thread.

[Sheldon Rowan @SheldonRowan]

@EricTopol If anybody is wondering about omega-3 supplements for prevention of cardiovascular disease, the NIH has an amazing summary about this. Eric is 100% correct, but something to think about for those that do not eat fish or seafood. https://t.co/E8eUj1wEpS

[Dr DorotaSK @DrDorotaSK]

Hi Friends! Did you hear about STAT Madness? Not enough space to explain now😀, but check it there: https://t.co/1vRDMx11Dc and VOTE for DSK lab! We’re competing with a project studying how lipid supplementation may improve aging vision. Thank you for your support!!! #aging #AMD