Sho Goh Lab

We find out where RNA modifications are, what they do, how they do it and why that matters

[Sho Goh Lab @ShoGohLab]

Thanks to @NatRevMCB for inviting me to highlight the paper that brought us direct-RNA-seq. It has been exciting using "my precious" nanopore to map RNA modifications.

[Nature Reviews Molecular Cell Biology @NatRevMCB]

New Online! RNA modifications: one ring to map them all https://t.co/vP2ROiLziK

[Sho Goh Lab @ShoGohLab]

Quite an innovative question

[Jonas Koeppel @JonasKoeppel]

1/n What fraction of the human genome is essential for cellular viability?

Excited to share our preprint that explores this question by combining an unusual CRISPR system, phage promoters, and thousands of deletion launchpads.

@sudpinglay @JShendure

https://t.co/rTO1MyFv3q

[Sho Goh Lab @ShoGohLab]

This is why we need biomedical research

[NEJM @NEJM]

Presented at #ASCO26:

Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: https://t.co/xwLWBZYRzq

@ASCO

[NEJM @NEJM]

Presented at #ASCO26:

Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: https://t.co/xwLWBZYRzq

@ASCO

[Sho Goh Lab @ShoGohLab]

I... this is... wait what?

[Arjun Raj @arjunrajlab]

Okay, I made an Atlas of Cell Atlases. Will post code later.

[Igor Ulitsky @IgorUlitsky]

Now out in @NatureBiotech ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones. https://t.co/01NroM67dK

[Kevin McKernan @Kevin_McKernan]

Probably Craig Venters last interview.

The people who drone on about the necessity of NIH “basic science” are the duds and dropouts of the class.

It’s food stamps for the underachievers.

[Nature Biotechnology @NatureBiotech]

Scalable single-cell total RNA sequencing unifies coding and noncoding transcriptomics https://t.co/aXZIPsWXDG

[Sho Goh Lab @ShoGohLab]

Achievement unlocked: 1st PhD graduated from the Goh lab, Dr. @huihuian521

[Leah Pierson @leah_pierson]

omg this title, this paper

[Mile Sikic @msikic]

@fchollet You are my AI hero. However, I disagree about biology. At this moment, we need more high-quality data, the proper measures, and relevant questions. I actually wrote about this earlier today https://t.co/q3LZlOIPja

[Hailing Jin @hailingj1]

Our new discovery that bacteria utilize extracellular vesicles to deliver RNAs into fungi substantially broadens the paradigm of Cross-Kingdom RNA communication! Big congrats to ⁦@J_NinoSanchez⁩, ⁦@HuaitongW⁩ and all! Thanks for your hard work! https://t.co/7OAMaItcxa

[Sho Goh Lab @ShoGohLab]

@hailingj1 @J_NinoSanchez @HuaitongW Congratulations Hailing!

[Sho Goh Lab @ShoGohLab]

Just finished giving the last talk at this amazing Asian RNA Club Symposium that was full of other talks and posters with new unpublished stories. Looking forward to the next Symposium in 2 years at Nara, Japan!

[Shinichi Nakagawa @smoltblue]

アジアRNA業界の至宝Narry Kimさんのご尽力で開催がようやく実現したAsia RNA Clubの記念すべき第一回ミーティングがソウル大学でいよいよ始まります！

[Shinichi Nakagawa @smoltblue]

アジアRNA業界の至宝Narry Kimさんのご尽力で開催がようやく実現したAsia RNA Clubの記念すべき第一回ミーティングがソウル大学でいよいよ始まります！

[Sho Goh Lab @ShoGohLab]

I was amazed by this tour de force to profile 16 different RNA modifications simultaneously when i first heard @SchragaSchwartz talk about it. I'm still amazed now.

https://t.co/tQ1bWCHLZy

[Sho Goh Lab @ShoGohLab]

Cool teacher's day gift from my amazing PhD students!

[Sho Goh Lab @ShoGohLab]

Always great to have old friends visit us in SZ. Today, fellow HannonLab alumnus @Elvin_Wag from @IcahnMountSinai visited us at @ShenzhenBayLab to share his experience researching cancer stem cells, give career advice to our young scientists and enjoy our famous roast pigeon

[Sho Goh Lab @ShoGohLab]

@YiliangDing @JohnInnesCentre @CarolineDeanLab @DingLab_RNA Congrats!

[Sho Goh Lab @ShoGohLab]

Why is it suddenly so difficult to buy phase-lock tubes? Anyone knows anyone who's still selling?