Thrilled to watch our trivalent PROTAC work finally out. So incredible journey from concept to practice, and again awesome collaboration with the amazing Kristin and @danetteldaniels@promega There’s a curious backdrop story on how it all started, keep reading below 👇🏼
🧵 Hi new followers! I’m Keith, medicinal chemist @ArvinasInc. I post on targeted protein degradation, med chem “wisdom”, industry careers, and various pharmacology/PK tweetorials. This thread of threads (!) rolls up links to all of my previous tweetorials; see below.
Dear Twitter friends, has anyone reached out to organizations/societies asking for recommendation letters for visa purposes? Any ideas on how to contact the right person/department?
@isth@AACR@AmerChemSociety
So pleased to share this @nchembio review by NIBR’s Josh Paulk on lysosome-targeting chimeras -- LYTACs. Great to see so much progress in understanding this relatively new member of the TPD family in recent months. https://t.co/3ISRdZDxA8
Good review article on Heparin Resistance by @JerroldLevy and @connors_md in this week's @NEJM.
I never knew that andexanet alfa use is a cause of heparin resistance.
Excited to see our study officially published in @NatureComms. Here, we report the identification of ZNF768 as a new protein linking oncogenic RAS to cellular #senescence.
Here comes a brief summary of our paper👇.
https://t.co/Xrna7Y735t
Last year myself and a great group of people wrote an @RPTHjournal article on how best to utilise Twitter for conferences in the COVID world.
Make sure to give it a read before #ISTH2021 and use Twitter as best you can! @isth@JTHjournal@IsthPresident
https://t.co/1izKn3VOeL
The countdown to #ISTH2021 is drawing to a close. Register now for your last chance to participate in the LIVE conversation with experts around the globe. While you're at it, also sign up for the virtual 5K. Get started here: https://t.co/OXPN6Mojtv
Follow us and all other @isth Twitter Ambassadors #ISTH2021 for all updates! Lots of options real-time and on-demand! Still time to register:
https://t.co/AzoEo1CB79
Very excited to share the amazing science from #ISTH2021#scicomm
Follow my fellow Twitter Ambassadors👇, tag us in your virtual congress posts, and help us share your work.
Announcement: See the official #ISTH2021 Twitter Ambassadors! These esteemed communicators will be tweeting throughout the Virtual Congress and highlighting the science presented. See below for their Twitter handles.
Stellar perspective from the @CraigMCrews lab that lays out the themes for the next decade of TPD: drugging the classically undruggable, new E3 binders (incl. disease/tissue specificity), and ⬆️ design cycle efficiency via structural biology and modeling.
https://t.co/Iw1tD4J9f9