Sigmar Stricker

Scientist in developmental biology/regenerative medicine. Full time dad, part time mountaineer. Private account, opinions are my own; professional: @StrickerLab

[Sigmar Stricker @SigStric]

Ever wondered how Lymph Nodes emerge during development? Turns out that mesenchymal stromal cells take the lead once more!

[StrickerLab @StrickerLab]

Paper alert! Super proud to share Pedro Vallecillo’s postdoc masterpiece now online @ImmunityCP: A local subset of mesenchymal cells expressing the transcription facto... https://t.co/u6LaetTOph

[Abhishek Sampath Kumar @AbhiSampKumar]

Excited to share the second piece of my PhD work! Our paper on generating 2D and 3D spatial transcriptomic maps of whole mouse embryos during early organogenesis with @adrianobolondi @Luyi_T is out in @NatureGenet 🐭🧬 @MPI_MolGen @broadinstitute.
https://t.co/Bz7vDWeAag

[Fabien Le Grand @LeGrandLab1]

Delighted to share our latest work on BioRxiv. During her PhD, @GarciaPaulineJ relentlessly studied the impact of removing the H3K9 methyltransferase Setdb1 in muscle stem cells. Strikingly she found Setdb1 is absolutely required for regeneration 1/n
https://t.co/V6m2gVwE7l

[StrickerLab @StrickerLab]

Wer hat sich schon mal gefragt, wie Lymphknoten eigentlich im Embryo entstehen...? Tip: mesenchymale Stromazellen sind der Schlüssel! @VBIOeV @GfEeV @bionity_de @TVVde

[Sigmar Stricker @SigStric]

We soon realized that Osr1 KO mice do not form lymph nodes, and asked whether mesenchymal cells at the sites of lymph node initiation might use overlapping mechanisms to those that coordinate muscle patterning. In a nutshell, they do…

[Sigmar Stricker @SigStric]

Ever wondered how Lymph Nodes emerge during development? Turns out that mesenchymal stromal cells take the lead once more!

[StrickerLab @StrickerLab]

Paper alert! Super proud to share Pedro Vallecillo’s postdoc masterpiece now online @ImmunityCP: A local subset of mesenchymal cells expressing the transcription facto... https://t.co/u6LaetTOph

[Sigmar Stricker @SigStric]

While doing genetic lineage tracing we realized massive contribution of Osr1+ mesenchymal cells to nascent lymph nodes, which was a classic “hm… that’s funny” moment.

[Freie Universität @FU_Berlin]

Neue Erkenntnisse zur Entstehung von #Lymphknoten:
Forscherteam unter Leitung von Wissenschaftlern @fu_berlin identifiziert Stromazellen als wichtigen Faktor für die Anlage von Lymphknoten ⬇️
https://t.co/HoODfhNUmd

[Sigmar Stricker @SigStric]

@osvaldoics @StrickerLab @ImmunityCP Thanks Osvaldo!

[Sigmar Stricker @SigStric]

@der_bri @BIHregeneration @MPI_MolGen @berlinnovation @ERC_Research Congratulations Daniel, awesome 👏

[Sigmar Stricker @SigStric]

Spearheaded by @GeorgeKotsaris
Great collaboration with Sven Geissler @ChariteBerlin @berlinnovation , the Knaus lab @fubcp @FU_Berlin , @THQazi , @LeGrandLab1 , @MPI_MolGen

[Sigmar Stricker @SigStric]

New study from our lab: We show that Osr1 is a key transcriptional regulator of FAPs during muscle regeneration. Osr1 is required to sustain pro-regenerative FAP function, loss of Osr1 leads to a detrimental pro-fibrotic state in FAPs actively suppressing regenerative myogenesis

[StrickerLab @StrickerLab]

Hey #myotwitter new paper from the lab now online: https://t.co/XGxkDHGnqS
@GeorgeKotsaris shows that Odd-skipped related 1 is a central regulator of FAPs in skeletal muscle regeneration

[Wickstrom-Lab @WickstromLab]

We took on the challenge with @KateMiro1 to illustrate key aspects of #nuclear #mechanotransduction in a single #snapshot 👇Hope it’s useful! https://t.co/vdXFS9ZAhx

[Metis ~ 🐭 🐰 🐷 🐶 🐱 🐵 🧑‍🔬 @TweetsMetis]

This is why scientists to #animaltesting.

The first humans to take the drugs will be the volunteers in the first round of clinical trials. The mouse is here to make sure it's safe for them.

#Animalresearch saves lives.

#scicomm. Thx @animalresearch

[Frontiers In Myogenesis @MuSCandReg]

Hurry up #MyoTwitter 💪 folks!

- Abstract deadline: June 13
- Early Registration (at discounted rates): June 23
- Trainee travel grants: available 🥳
- Childcare grants: available 👶

Info: https://t.co/4TPj6pXLa7

[Sigmar Stricker @SigStric]

@MatthewJHilton @CellReports @Abbyleinroth @DukeOrtho @DukeCellBiology @DukeDscb Congratulations Matthew, very nice work!

[Matthew J. Hilton @MatthewJHilton]

Excited to see our work with non-myogenic skeletal muscle resident mesenchymal cells is out today in @CellReports ! Excellent work @Abbyleinroth and team!@DukeMedSchool @DukeOrtho @DukeCellBiology @DukeDscb

[VingronLab @VingronLab]

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Interested in the identification of #markergenes from single-cell data? Now it’s possible using our “Association Plots” adapted to SC data!

https://t.co/4p6vTH4UES @JmolBiol

by @ela_gralinska, @ClemensKohl, Bita Sokhandan Fadakar, and Martin Vingron

#scRNA #Rpackage

[Fabien Le Grand @LeGrandLab1]

Je cherche à embaucher un bio-informaticien pour travailler sur les approches ATAC-seq en noyaux unique. I am hiring a bio-informatician to work on single nuclei ATAC-seq. Please spread!

[Sigmar Stricker @SigStric]

Saw this only now; congratulations Shahragim! @LabTajbakhsh

[Tajbakhsh lab @LabTajbakhsh]

Pleased and Honored to have received an #ERC Advanced Grant for STENIPATH. Impact of distal pathologies on stem cell function in mouse and human. Lots of fun experiments! Please apply 🧐😊