Simon Breidert

Physician

[Simon Breidert @SimonBreidert]

"WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome"
https://t.co/rxsorxSrI9

Induction of ER stress could play a role in several diseases that include fatigue.

@MEcfsTogether
@dg_mecfs

#MECFS

[Simon Breidert @SimonBreidert]

Great and easy to understand post by @DrRuscioDC on gut dysbiosis and neuroinflammation.

https://t.co/YwrIpta4OJ

I would like to add that fasting and caloric restriction is also effective for dampening inflammation.
https://t.co/PxykK4xg6z

[Simon Breidert @SimonBreidert]

@CosimoMelcangi https://t.co/9Jp5Gi0Myv

[Simon Breidert @SimonBreidert]

1.) Interesting article on the possible cause of post-exercises malaise in ME/CFS
https://t.co/ECNYyqBXyk

@dg_mecfs @MECFS_Freiburg @MECFS_Bayern

Interstingly, many Post-Finasteride Syndrome patients also report Post-exercises malaise...

[Simon Breidert @SimonBreidert]

3.) Interstingly, a recent study by @CosimoMelcangi found inflammation in the gut of rats after 1 month after withdrawal of finasteride (increase of IL-1β and TNF-α). Leaky gut has not been confirmed in these animals - although I personally find it likely happens in PFS.

[Simon Breidert @SimonBreidert]

@anmol462791 It's my personal opinion. But I think yes, neuroinflammation, might take place in PSSD with downstream consequences on SRD5A2.

But everything here - even for ME/CFS should be taken with a grain of salt.

[Simon Breidert @SimonBreidert]

@iatrogenic_harm - Interaction with ACE2
- changes of sex hormones or LH

I personally can think of that withdrawal of these medications could cause inflammation in certain organs (gut lining, reproductive system, brain) with inflammation leading to epigenetics changes.

[Simon Breidert @SimonBreidert]

We see that often in PFS, PSSD and PAS that re-exposure or cross-exposure of finasteride, SSRIs or isotretinoine even after many years of pause can lead to a sudden onset of these diseases - after just a single pill.

Big question: Why?

[🏁The iatrogenically harmed menstruatrix🤐🕷️ @cheesyredrocket]

@SimonBreidert @JuhanaSakari A decade between one pill of citalopram and 1/6th of a sertraline pill causing completely opposite side effects...

[Simon Breidert @SimonBreidert]

@PSSDSimon @FinasterideInfo I think there might be a trap looking to closely on the main pharmacological actions of SSRIs. There might be thousands of other things that SSRIs can do. I think it's important to look left & right which other compounds (fin, iso) can cause similar symptoms & find commonalities

[Simon Breidert @SimonBreidert]

@JuhanaSakari @FinasterideInfo @Max94Cold

[Simon Breidert @SimonBreidert]

5.) Note that some PFS patients report to have a window of improvement after use of antibiotics or inuspheresis before usually relapsing.
The bacteria could theoretically also cause autoimmune antibodies when getting in contact with the immune cells in the blood.

[Simon Breidert @SimonBreidert]

@anmol462791 @s4m4rn0ld @Denis_protocol @NoahRyanCo I haven't seen much hypothyroidism yet. It's also pretty common in the general population. Would love to see numbers from both groups

[Simon Breidert @SimonBreidert]

@SadxLady @Leona_Moore95 @ROSIE_PSSD True. But discussion should be 80% about research and 20% about what to try. Not the other way around. Otherwise these diseases might never get fixed.

[Simon Breidert @SimonBreidert]

What research tool is the best for getting the best understanding of a the pathomechanism of a disease?

[Simon Breidert @SimonBreidert]

@ROSIE_PSSD @Leona_Moore95 At least a month I would suggest

[Simon Breidert @SimonBreidert]

@Leona_Moore95 @ROSIE_PSSD In my opinion the right question. I would say it needs a comparable control group with similar age and lifestyle. Problem is that many in the PFS and PSSD communities are popping supplements and hormones like smarties. Ideally they pause them some time before such a study

[Simon Breidert @SimonBreidert]

@SirCrypto19 @HLcure2020 @Hairtransplant_ @AlopeciaNoMore @ddg_derma @DermatologyNews @HairLossInWomen @HairlossUK @Merck @AmyPearlman1 @CatherineSNamMD @stopharmingus When that will be treatable depends mainly on the efforts of the patient communitites.

[Simon Breidert @SimonBreidert]

@lifeanalytics @cherylbenson Maybe neuroinflammation as initial cause.