Spektor Lab

[Spektor Lab @SpektorLab]

@freddyeescorcia @Nature @chowdhury @aniruddhSark Thanks so much, Freddy!

[Spektor Lab @SpektorLab]

(1/5) I am delighted to share our study published today @Nature https://t.co/BjJbHT9qWe collaboration with @Chowdhury Lab, led by @XiaoZheng3and @aniruddhSark. Huge congratulations to all the authors and collaborators.

[Spektor Lab @SpektorLab]

@ranjitbindra @YaleCancer @YaleRadOnc @Yale_Ventures @CT_Innovate @sontagfdn @brightedge @NBTStweets @HerzonLab Congrats, Ranjit! Very exciting!

[Spektor Lab @SpektorLab]

Terrific session dedicated to the memory of Angelika Amon, with a tribute by @JSheltzer and outstanding talks by @JSheltzer, @ZStorchova, @SteSantaguida and others. #ANESRC

[Spektor Lab @SpektorLab]

Terrific session dedicated to the memory of Angelika Amon, with a tribute by @JSheltzer and outstanding talks by @JSheltzer, @ZStorchova, @SteSantaguida and others. #ANESRC

[Spektor Lab @SpektorLab]

Excited to welcome aneuploidy scientific community in sunny Melbourne, FL. Can't wait to see everyone. #ANESRC

[Spektor Lab @SpektorLab]

Because CDK5 is overexpressed in many cancers and is associated with a poor prognosis, our study raises the possibility that these cancers may be more dependent on CDK5 for their cell division and suggests that CDK5 may be an important therapeutic target.

[Spektor Lab @SpektorLab]

The study alters the existing paradigm that CDK1-Cyclin B1 is the only CDK-cyclin complex essential for all stages of mitosis and raises the possibility that other atypical CDKs may also have a role in regulating the cell-division cycle.

[Spektor Lab @SpektorLab]

Loss of CDK5-Cyclin B1 interaction abolished CDK5 activity in vitro (thanks to our collaborator Kavita Shah) and phenocopied CDK5 abrogation in mitosis. CDK5–cyclin B1 is thus a canonical CDK–cyclin complex that plays an essential role in maintaining genome integrity.

[Spektor Lab @SpektorLab]

Surprisingly, we discovered that CDK5 forms a functional complex with Cyclin B1, the mitotic cyclin that partners with CDK1 to complete all stages of mitosis.

[Spektor Lab @SpektorLab]

With the help of our collaborator @AmandaPaulovich, we used phosphoproteomic analysis to identify putative CDK5 substrates that may account for this phenotype.

[Spektor Lab @SpektorLab]

Using two orthogonal chemical genetic approaches, we show that CDK5, an atypical CDK essential in non-dividing neuronal cells, plays an important role in mitosis in preventing mitotic errors. Abrogation of CDK5 prior to mitosis led to chromosome mis-segregation and nuclear atypia

[Spektor Lab @SpektorLab]

We found that these errors occur because spindle microtubules that separate sister chromatids during mitosis become abnormally stable in the absence of CDK5, preventing cells from correcting chromosome attachment errors.

[Spektor Lab @SpektorLab]

Cyclin Dependent Kinases (CDKs) are critical for regulating different phases of the cell cycle and CDK1 was considered to be the only CDK essential mitosis.

[FASEB @FASEBorg]

We want your research at #ANESCR to help organizers @GodekLab, @LabSpektor, and more unpack the Consequences of Aneuploidy. Submit your abstract by July 21 and save your space: https://t.co/loFrxX4Hu1

[Ofer Shoshani @ShoshaniOfer]

Abstract deadline coming up! Hurry and register to the FASEB "Consequences of Aneuploidy" meeting in Florida (Sep 15-19). This meeting gathers top scientists studying chromosomes, cancer genomes, mitosis and meiosis, and more.

More details:
https://t.co/cdG98T1Xhe

[Spektor Lab @SpektorLab]

@HenningWillers @IJROBP @ASTRO_org Congratulations, Henning, on taking on this important role!

[Ralph Weichselbaum @rweichselbaum]

My apologies the word artistic I meant self-absorbed, and I apologize again

[Spektor Lab @SpektorLab]

@Samuel_Bakhoum Beautiful story, @Samuel_Bakhoum and @LaughneyLab! It's great to see it out. Congratulations!!