Andrew Steele

Longevity scientist / Author of / Presenter / Co-Founder and Director @longevityinit

[Andrew Steele @statto]

Ageless: The new science of getting older without getting old is out in paperback!

‘A tour de force of anti-ageing science’ – @thetimes
‘A fascinating look at how scientists are working to treat the aging process itself’ – @drsanjaygupta

Buy a copy at https://t.co/T9k6uASUmn

[Vladimir Leshko @vladileshko]

Met Kamen and Andrew from @longevityinit at Vitalist Bay.

They’re working on one of the highest-leverage longevity plays: getting governments to pour BILLIONS into aging research.

Advocacy like this might be 100x–1000x more impactful than funding research directly.

Make sure to follow the Longevity Initiative and send all your 🤎

[Andrew Steele @statto]

Please give us a follow on LinkedIn!

[The Longevity Initiative @longevityinit]

We’ve been on there for a while, but just officially launched on @LinkedIn!

Check out our article on what we started a think tank, not a biotech – and please give us a follow over there and share our page with your network. https://t.co/W0pqLkOexP

[Andrew Steele @statto]

@greenlandsharky @KristerKauppi @OMIPALRLL @OraBiomedical @benblueAK @mkaeberlein Sure, it’s not a slam-dunk! And I don’t know enough about quercetin specifically to say much else…

[Andrew Steele @statto]

@greenlandsharky @KristerKauppi @OMIPALRLL @OraBiomedical @benblueAK @mkaeberlein No, and also quercetin is often touted as a senolytic, and C. elegans are post-mitotic! I’d still rather see it improve worm lifespan all else equal though. :)

[Krister Kauppi - Rapamycin Longevity Lab @KristerKauppi]

The largest-ever lifespan analysis of 601 mTOR modulators is now completed! This project has been driven by Rapamycin Longevity Lab (@omipalRLL) in partnership with @OraBiomedical (CEO @benblueAK, CSO Yan Ting Zhao, AI Engineer Ishan Ranasinghe, Co-founders @mkaeberlein , @BKennedy_aging, @mitchellblee33, @jangruber467 & Jason Pitt). Our mission has been to identify compounds even more potent than Rapamycin in extending lifespan in roundworms.

I am deeply grateful for the community’s support for this historic project and big thanks to all our sponsors who made this possible!

Our Gold Sponsors:
✅ Melissa Burdick & Brian Burdick: Great tech leaders and e-commerce pioneers. Connect with Brian and Melissa on LinkedIn to follow their work.
✅ Antoine Dusséaux: A London-based entrepreneur. Connect with him on X via @adssx
✅ Dmitry Sadovnikov: Connect with him on LinkedIn or X via @ksajxai
✅ Ciarán Murray: A longevity enthusiast and tech founder of @OlasProtocol. Connect with him on X via @C1aranMurray
✅ Anonymous: Two anonymous contributions to the project and one by Anonymouse.

Other Sponsors of the Project:
✅ @agelessrx_ : A cutting-edge telemedicine platform specializing in making various longevity interventions accessible, actively involved in research and clinical trials.
✅ Winslow Strong: Dedicated to advancing human health and wellbeing. Follow him on X @winslow_strong.
✅ Dr. Grant Fraser: Specializes in longevity medicine, integrating lifestyle interventions with personalized medical treatments.
✅ @OpenCuresOrg: A unique online platform empowering individuals, health professionals, labs, and researchers to accelerate longevity interventions.
✅ Revi Health (@johanhedevag): Modern clinic in Sweden combining regenerative medicine, performance health, and longevity protocols for measurable results.
✅ @healthspanmed: The first-ever digital medical clinic helping patients fight cellular senescence and regain control over the levers of aging.
✅ Rapamycin Longevity Lab (@omipalRLL): Our mission is to become the leading expert around mTOR inhibitor-based combinational therapies for longevity.
✅ People in the longevity community: Thank you for every donation, like, and share. Your support has fueled this project!

PS 1: Big thanks also to Victor Björk for the help with the fundraising!

PS 2: All lifespan data is now available on the Rapamycin Longevity Lab’s LID database (link in the comment section). You can find the top 20 and bottom 20 lists right here in the social media image! Big thanks to Andrew Steele (@statto) for the great suggestion to create a bottom list as well!

PS 3: The next step is to collaborate with different parties to analyze the data and also see if the data translates to other species. Reach out if you want to collaborate!

[Andrew Steele @statto]

@MotionlessStall @celinehalioua :) https://t.co/tKBDcMzSle

[Andrew Steele @statto]

@celinehalioua How’s about ‘real anti-aging drugs’?

[Andrew Steele @statto]

@celinehalioua How’s about ‘real anti-aging drugs’?

[Andrew Steele @statto]

Great response from Adam to an unfortunately dismissive post from @EricTopol.

As Adam notes, he very much doesn’t believe ‘aging is optional’, and he *is* often the most pessimistic person in the room—he just thinks we should be trying harder! Pretty reasonable, IMO!

[Adam Gries @adamgries]

I was very sorry to read this post, especially as a reader of Ground Truths and somebody who has appreciated your analyses of various health topics.

That said, I am compelled to respond as a co-founder of Vitalism Foundation.

1. At Vitalism Foundation we hold ourselves to the highest scientific standards. This is evidenced by the fact that leading professors from top institutions, government leaders from ARPA-H, respected physicians, and founders of public companies have been proud to present at our events.

We would never condone a sticker saying something like “aging is optional”, since it is clearly not currently optional. *That* is the problem.

I’m not sure how such a sticker was connected to us, and was also sad to read the implication that we inappropriately promote certain technology “all kinds on unproven tech”; scientifically rigorous early stage products are not snake oil.

Which tech is unproven in your estimation?

Is it the DEXA scans? mainstream blood assays such as lipid panels? The continuous glucose monitors we provided as part of a partnership with Abbott?

Please be specific. If there is anything we are missing or faulty in, we’d like to know so we may correct it.

2. It’s baffling that one would take issue with the conservative numbers in the lifespan survey STAT conducted (on their own initiative).

When every other day we are promised by titans of industry that we will soon double the lifespan (Amodei) or eradicate all diseases (Hassabis, Zuckerberg), one may find the vitalist bay crowd rather conservative, since a sizable majority of respondents (65%) didn’t think they would live substantially longer than current lifespans.

It’s exactly that grounded sober view that drives Vitalism Foundation to work to secure more funding for basic science and innovation so we can find the breakthrough we sorely lack.

3. One of our key problems in dealing with Aging is a prevalent cargo cult mentality that aging is immutable, despite ample evidence to the contrary.

While I do not believe you hold this view, it is a perspective that has arrested the progress of much good science and therapeutics that could help extend healthspan and lifespan in the here and now, without talking about anything so grandiose as eradicating all disease.

4. I hope you will join us at the next Vitalist Bay and judge things for yourself.

You would be my honored guest.

[Andrew Steele @statto]

@Aging_Scientist @longevityinit Oh I see, yes, familiar with that!

The issue then is surely that there aren’t major knockout mutations in human populations that we can do to mice in the lab, right?

[Andrew Steele @statto]

Cancer gets over 80 times more research funding per death than ageing does—even though ageing *causes* most cancer.

Please share the new analysis from @longevityinit!

[The Longevity Initiative @longevityinit]

Does NIH research funding track what actually kills Americans?

Building on @theA4LI’s new report, we ran the numbers: and ageing fares worst.

Ageing causes 83% of deaths, yet receives just 1.2% of the research funding per death that cancer does—around $1 per American per year.

[The Longevity Initiative @longevityinit]

Lovely to see a spike in traffic for our 2025 longevity business round-up last week as the @RetroBio_ news broke!

If you're catching up on the reprogramming gold rush, the biotech funding drought and recent big exits, it’s all here: https://t.co/n8bC046ToU

[Andrew Steele @statto]

@Aging_Scientist @longevityinit Totally agree with what you say about mutations, though. That’s surely the geroscience answer here—if we could improve DNA repair, fix them after the fact, preferentially kill expanded clones, etc it seems likely we’d impact both cancer and wider ageing.

[Andrew Steele @statto]

@Aging_Scientist @longevityinit I’d be interested to see the GWAS, I’ve not heard that argument before! It could be that humans are very genetically homogeneous in aging terms, but than it would surprise me that mice aren’t, unless it’s across strains?

[Andrew Steele @statto]

@AlexanderMWolf7 @schw90 @JayRoshe5 @longevityinit But given that you closed your reply with ‘Leave medicine to the professionals’, I guess you’re not very interested in actually discussing science or policy, but trading insults.

So I’ll leave this here. Have a great day!

[Andrew Steele @statto]

@AlexanderMWolf7 @schw90 @JayRoshe5 @longevityinit As I explained, it’s not the number of years but the amount of funding. Cancer has had around 30× more funding historically.

If you can point to a place where I’ve ‘just demanded more money without bothering to propose something specific’ I’d be happy to see it!

[Andrew Steele @statto]

@AlexanderMWolf7 @schw90 @JayRoshe5 @longevityinit We’ve been over this many times before, Alexander… Historically, ageing has had a few percent the public funding of cancer, and only recently has private funding ascended to those dizzy heights of also a few percent. It’s small wonder we’ve not got much to show yet.

[Andrew Steele @statto]

@schw90 @JayRoshe5 @longevityinit …evidence that clonal expansions affect ageing more broadly too (eg clonal haematopoiesis increasing risk of heart disease).

Cancer diagnostics doesn’t touch any of that.

[Andrew Steele @statto]

@schw90 @JayRoshe5 @longevityinit I don’t think this is right, for two reasons: the ageing strategy is ‘don’t diagnose, stop it ever reaching stage 0’, ie reduce clonal expansion of cells, selectively kill cells with/repair common driver mutations, etc. And this probably wouldn’t just help with cancer: we have…

[Andrew Steele @statto]

@schw90 @JayRoshe5 @longevityinit The traditional cancer research approach certainly isn’t SENS-like though—that would suggest intervening after mutations have accumulated but before they cause cancer, and almost all cancer research concentrates on after the cancer exists.

[Andrew Steele @statto]

@schw90 @JayRoshe5 @longevityinit I’m certainly not modelling oncologists or NCI leaders as stupid! But training in aging biology is almost nonexistent for many biologists, and the field has been tiny historically and marred by snake-oil claims so many are initially over-sceptical, in my view.