Stavros Giaglis, PhD

Senior Scientist - Project Leader, University of Basel, DBM
Neutrophil geek, Immuno-synovial organoids dreamer

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The Norwegian Nobel Committee has decided to award the 2026 #NobelPeacePrize to Navanethem “Navi” Pillay for her efforts to promote peace and international law.

#NobelPrize

[Eric Topol @EricTopol]

A remarkable study of 12 million single-cells (RNAseq) from 8 cohorts plus proteomics to determine the immune cells linked to healthy aging. Major findings included:
—thymic involution is central (decline in naive T cells and thymic emigrants)
—elevated immune system activation, inflammaging
—CD8+ memory cells (GZMB+) high frequency
—CMV seropositivity and chronic disease
@ImmunityCP by @maxim_artyomov and colleagues
https://t.co/aQNQiapfPV

[The Nobel Prize @NobelPrize]

Anne Carson – awarded the 2026 #NobelPrize in Literature – once described boredom as her arch-enemy. It is a state she confronts with drastic humour and wit.

‘The Beauty of the Husband: A Fictional Essay in 29 Tangos’, published in 2001, tells of a cutting and sardonic row with a deceitful husband, its twenty-nine episodes each opening with lines of verse by the romantic poet John Keats. Keats’s sublime words about beauty being truth are, in brutal yet playful fashion, juxtaposed with this exhausting relationship drama.

[Stavros Giaglis, PhD @StavrosGiaglis]

https://t.co/QnIDS13O6b

[NEJM @NEJM]

Karl Deisseroth, MD, PhD, winner of the Nobel Prize in Physiology or Medicine 2026, describes the science behind a study of intravitreal delivery of an AAV vector encoding a light-gated ion channel in 10 blind patients with advanced retinitis pigmentosa.

Read the editorial “Optogenetics in Sight”: https://t.co/efK5Hs2igp

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”

[Stavros Giaglis, PhD @StavrosGiaglis]

Enrichment and Proteomic Profiling of Stromal‐Associated Extracellular Vesicle Subpopulations From Arthritic Synovial Fluid by Size‐Exclusion Chromatography Coupled to CD90‐Directed Immunocapture - Kurth - 2026 - Journal of Extracellular Vesicles https://t.co/dhYk9wjv5U

[やまだ@へっぽこ研究者｜Y.KITA @tarou_ymd_]

ひとつのmRNAは、ゲノムの一箇所から作られる。この前提が崩れたかもしれない。

ハーバード大のグループが、逆転写酵素を使わない直接RNAシーケンシングでマウスのマクロファージを調べたところ、別々の遺伝子の配列がつながった「キメラmRNA」が3万種以上見つかった。その約88%は、異なる染色体どうしの組み合わせ。

炎症が起きると、離れた染色体上の遺伝子が核の中で引き寄せられ、そこでRNAが正確な一点で連結される。この接近はゲノムの折りたたみを担うCTCFに依存していた。

なかでもGsdmdとTmem106aが融合したmRNAは、データベースに存在しない新しいタンパク質をコードしていた。細胞膜であらかじめ待機し、炎症性細胞死の実行役GSDMDが穴を開けるのを加速させる「先回り役」らしい。量は本家Gsdmdの1割未満だが、1割足すだけでIL-1β放出はほぼ倍に。

マウスでは、これを失うと敗血症に強くなる一方、サルモネラ感染には弱くなった。感染防御と免疫の暴走が、同じつまみの両端にぶら下がっている。

がん細胞の異常として語られてきた融合遺伝子が、健康な細胞の正常な仕組みとしても存在する。狙える創薬標的の地図には、まだ空白がありそう。
https://t.co/6SRciFDL3h

[Nature Rev Immunol @NatRevImmunol]

Drugging the immune system: principles of immunopharmacology https://t.co/NEUjMBw5nP

[Waggoner Lab @LabWaggoner]

Neutrophils adopt a tissue-adapted state at the early maternal-fetal interface that supports trophoblast invasion
https://t.co/hOCHtFCXeq @SciImmunology @AnnaLeukin10

[Sergiu P. Pasca @Sergiu_P_Pasca]

Here’s a short summary of our recent #xenocortication article in @Nature, including the rationale, approach, key findings, initial applications to disease modeling, and current limitations.

A tremendous effort led by Konstantin Kaganovsky, Kevin Kelley, Tilo Gschwind, and Paul Harary.

Link to the article below

[Nature Rev Immunol @NatRevImmunol]

The next big questions in immunology https://t.co/JPTwmdi9Ej

[Stavros Giaglis, PhD @StavrosGiaglis]

https://t.co/vNO165STVK

[Vishva Dixit @dixitvishva]

SURPRISE! Key interferon-stimulated genes (ISGs) can be induced without interferon! Sounds like an oxymoron, but it is true! Read the paper to find out more.

Switching of transcriptional control from interferon regulatory factor 2 to interferon regulatory factor 1 drives innate immune cell activation: Cell https://t.co/sozKwaQE39

[Eric Topol @EricTopol]

How do cells die? What used to be thought were 2 ways, now it's >20
https://t.co/pRnIaxdll6

[Martin Picard @MitoPsychoBio]

Cells exchange mitochondria.

[Felix Scholkmann @FScholkmann]

High-resolution 4D imaging of mitochondrial phenotypes (Agarwal et al., 2026, https://t.co/rgnspX5XZz).
"Mitochondrial form encodes bioenergetic function"

[Biomedical Picture of the Day BPoD @BPoD_s]

Do Callus: Bone fracture callus organoids implanted at long bone defect site orchestrate healing by natural processes

📹 Hanna Svitina et al @i_papantoniou lab, KU Leuven in @CellStemCell
➡️ https://t.co/MYecb5RTnO

[Stavros Giaglis, PhD @StavrosGiaglis]

https://t.co/ILB7X9GNnV

[Science Immunology @SciImmunology]

A new Science #Immunology study shows that #neutrophils can activate Rho-dependent #actomyosin to change cell contractility and enable them to migrate through confined capillaries. https://t.co/dsrEy5w1Vq