Subhash Khatri

metAGE Postdoc @MedUniGraz | Fighting heart aging with CR mimetics & exercise

[MetAGE - Cluster of Excellence @metage_coe]

Excellent research requires excellent teams! We are happy to have such a team!

At MetAGE, we explore how interconnected metabolic processes shape health over time and how we can support healthy aging, together.

#MetAGE #HealthyAging #Metabolism #Longevity

[Geromedicine @geromedicine]

Honored to launch the First Issue of Geromedicine (GER)! 🥂

Featuring groundbreaking work on the "Hallmarks of Aging" by Carlos López-Otín & Guido Kroemer, and clinical insights into NAD+ therapy. A must-read for the #Geroscience community.

Check it out: https://t.co/n8466vT503

[Geromedicine @geromedicine]

Thank you for the excellent breakdown, Dr. Almenawer!
We're thrilled to see this NAD+ review in our inaugural issue. Bridging the gap between geroscience and clinical application is exactly why we launched Geromedicine journal.

Read the full study:
https://t.co/sAKtgCH3v3

[Saleh Almenawer, MD @SalehAlmenawer]

Scientists just published a major review of human trials on boosting nicotinamide adenine dinucleotide (NAD+) — the molecule that powers your cells and declines sharply with age.

Here’s the breakdown, plain and simple:

Your cells run on NAD+. It fuels energy production, repairs DNA, quiets inflammation, and keeps mitochondria (your cellular power plants) humming.

As you age, NAD+ levels tank — leading to fatigue, slower recovery, weaker muscles, and higher risk of heart disease, diabetes, brain fog, and more.

You can’t just swallow NAD+ itself. Your gut and digestive enzymes break it down before it reaches cells.

That’s why we use precursors — safe compounds your body converts into NAD+.
The main ones:

• Niacin (nicotinic acid, a classic form of vitamin B3), but it often at high-doses causes uncomfortable flushing (skin redness and heat). Recent large studies show mixed heart benefits, and one 2024 paper linked excess niacin byproducts to inflammation and higher CV risk.

• Nicotinamide (NAM) — milder, but less efficient at sustained NAD+ boosts.

• Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) — newer, cleaner options that skip the flush and raise NAD+ more effectively.

This new review in @geromedicine looked at dozens of trials in middle-aged and older adults (2020–2025).

Real human wins:

• Better walking distance and grip strength

• Less fatigue and better physical performance

• Lower blood pressure, cholesterol, and body weight in some

• Reduced inflammation in immune cells and the heart

• Hints of brain protection (Parkinson’s, mild cognitive impairment)

• Improved mitochondrial function and insulin sensitivity

Most trials found these precursors safe and well-tolerated, with minimal side effects.

Between NR and NMN, I lean toward NMN. It’s one step closer in the conversion pathway (NR has to become NMN first), and recent human data show solid gains in energy, sleep quality, and metabolic health at doses like 250–1000mg/day.

My practical recommendation: Start with 500mg NMN daily (many take it in the morning). Higher-quality brands test for purity.

I’ve spent years digging into longevity science to help people make sharp calls on health.

This NAD+ pathway stands out because it has actual human evidence — not just mouse studies — showing we can dial back age-related decline.

Your vitality doesn’t have to slip away on the usual timeline.

Tools like NMN give you a real shot at holding onto more energy, strength, and resilience for longer.

[Geromedicine @geromedicine]

📢New Review-“Clinical evidence for the use of NAD+ precursors to slow aging”- For longevity science, this is a must-read.

Authors: @SubhashKhatri17 , @Mah_abdellatif and @simon_sedej

Read full: https://t.co/sAKtgCH3v3

[MetAGE - Cluster of Excellence @metage_coe]

New review from our team — @SubhashKhatri17 @Mah_abdellatif and @simon_sedej
For longevity science, this is a must-read.
👇A deep dive into NAD⁺ precursors, the clinical data behind it & how close we are to slowing human aging
#metage #Longevity #healthyaging

[Geromedicine @geromedicine]

📢Review-“Clinical evidence for the use of NAD+ precursors to slow aging”— explores current human trials on NAD precursors, highlighting promise, limits, and their potential to improve healthspan.

🔗https://t.co/l8tjHBS51U

#HealthyLongevity #aging #geroscience

[Subhash Khatri @SubhashKhatri17]

Excited to share our new review, now published in Geromedicine! 🎉
1. A deep dive into NAD⁺ precursors as anti-aging therapy
2.What the clinical data actually shows
3. How close we are in slowing human aging
#aging
@simon_sedej
@Mah_abdellatif

https://t.co/ddJqqYSXty

[MetAGE - Cluster of Excellence @metage_coe]

Good commnication is what truly matters - no matter if young or old, in our body or beyond.

What's your take on this?

#sciencecommunication #Longevity #agingfinelikewine #MetAGE #agingresearch #metabolicsignaling #communication

[Simon Sedej @simon_sedej]

Specific targeting of adipose tissue metabolism is superior to caloric restriction in treating obesity-related HFpEF | Cardiovascular Diabetology | Full Text https://t.co/pUW6gxO52y

[MetAGE - Cluster of Excellence @metage_coe]

🫀Obesity speeds up aging of the heart & vessels – through inflammation, cell stress, & mitochondrial dysfunction: MetAGE researchers @Mah_abdellatif & Frank Madeo have compiled current research.
🔗 https://t.co/JdwX0x4ljC
#MetAGE #HeartHealth #Obesity #AgingResearch #LONGEVITY

[MetAGE - Cluster of Excellence @metage_coe]

🎥 How does fat metabolism shape how we age? ORF featured 'MetAGE' in a short TV clip on our research about aging and metabolism in cell models and patients.
@UniGraz
@MedUniGraz
📺 Watch here (in German): https://t.co/wr1N5BG8Qe
#healthyaging #longevity #metage

[MetAGE - Cluster of Excellence @metage_coe]

🫀New publication from our cluster researchers: Blocking fat breakdown - not just eating less - may better treat #obesity-related heart failure (#HFpEF). Fat tissue might hold the key.👇
@simon_sedej @Mah_abdellatif @AndreasZirlik
@UniGraz @MedUniGraz @tugraz
#MetAGE

[Ullas Kolthur @UllasKolthur]

Mitochondria Time Your Exercise Capacity
Did you know your workout efficiency changes with the clock? 🏃‍♀️ Our research uncovers how mitochondrial energetics & SIRT4 regulate exercise performance during the day! 🌞🌙 Find out more: https://t.co/jSJrvMkZgc
@TIFRScience @TIFRH_buzz

[Ullas Kolthur @UllasKolthur]

Fond of sugar-sweetened beverages (SSB)? Preclinical study from #ARUMDA

SSB induced ‘#malnutrition’; increased sugar & reduced aminoacid gut uptake. 'Molecular addiction'

@Mahen_Son
@TIFRScience
@TIFRH_buzz
https://t.co/iXZCWiHG7S

https://t.co/jKxGww5jKf

[Ullas Kolthur @UllasKolthur]

Great effort by Sandra and @Shreyam_C @TIFRScience

Fed-fast dependent MiR biogenesis and consequent post-transcriptional regulation of hepatic genes is crucial for physiological homeostasis

[LifeScienceAlliance @LSAjournal]

Unravelling mechanisms that couple #circadian & #metabolic cues to regulate anticipatory #microRNA biogenesis @UllasKolthur @TIFRScience @TIFRH_buzz #Circadian independent #starvation Metabo-endocrine signals control #miR synthesis https://t.co/sOcK9qB41m

[Siddhesh Kamat @KamatLab_IISER]

Looking forward to this exciting meeting @TIFRH_buzz !!!

[BRIC - CDFD @BRIC_CDFD]

Assumption of Prof. Ullas Kolthur Seetharam as Director, Centre for DNA Fingerprinting and Diagnostics - CDFD

#cdfd @DBTIndia @UllasKolthur

[Siddhesh Kamat @KamatLab_IISER]

Congratulations and best wishes @UllasKolthur with your new journey @DBT_CDFD !!!