Delighted to share our latest work out in @J_A_C_S describing a general route to access 2-alkyl substituted 4-member rings from simple alkenes, becoming one of the most read articles of the month !! Kudos to the team 🎉 @SilviResearch@buck_louis77859
Thrilled to share our latest work in @J_A_C_S, describing a general route to 2-alkyl-substituted 4-membered rings from alkenes. Well done to @buck_louis77859, @Maria_Pelosi, and everyone else involved for the exceptional team effort. @ChemistryUoN https://t.co/Qp7EvquCSK
Thrilled to share that our brainchild is making its mark !!
The versatile vinyldineopentylsulfonium triflate is now available & ready for shipment by @EnamineLtd@SilviResearch
Looking to build oxetane-containing scaffolds? 🔎 Dineopentylvinylsulfonium Triflate enables efficient formation of oxetanes from alcohol-derived substrates under mild photochemical conditions. Developed by S. Paul and colleagues (https://t.co/UCGb8VtssT), this reagent works with a broad range of alcohols—including cyclic, acyclic, and heterocyclic—delivering oxetanes in excellent yields with high site selectivity.
✔️ Broad substrate scope for versatile scaffold design
✔️ Mild, photochemical conditions—no harsh reagents
✔️ Ideal for medicinal chemistry programs to tune 3D shape and physicochemical properties.
🛒 Available at Enaminestore with immediate shipping:
https://t.co/dOtpE17CRR
Find this reagent and many other useful reagents for synthesis, ready for immediate shipping to support your research 👉https://t.co/jQUxTUS8Ai
@SilviResearch
Thanks @WickensGroup for highlighting our work on the development of an homologative 1,3-dielectrophilic activation strategy for alkenes. Highlight online on https://t.co/pZD0hfpg42
#AmBeedNewsletter ✨ Recently, Professor Mattia Silvi's team (@SilviResearch) at @UniofNottingham published a research paper in @J_A_C_S titled "A Unified Synthetic Approach to 2-Alkyl Azetidines, Oxetanes, Thietanes and Cyclobutanes from Unactivated Alkenes".
💡Key Highlights
✅Atom economy: C1 homologation concurrently constructs C-X and C-C bonds.
✅Modularity: three-dimensional tunability of alkene, nucleophile, and substitution order.
✅ Functional group tolerance: compatible with acid-, base-, and oxidation-sensitive groups; obviates protecting group strategies.
✅Structural accessibility: streamlines synthesis of complex molecules previously requiring 5–10 steps.
📚🔻 𝐑𝐞𝐚𝐝 𝐦𝐨𝐫𝐞 𝐰𝐢𝐭𝐡 𝐀𝐦𝐛𝐞𝐞𝐝
https://t.co/oEtzRO8BiM
@ChemistryUoN #OrganicChemistry #Photocatalysis #Azetidines #Thietanes #Oxetanes #Cyclobutanes #MedicinalChemistry #DrugDiscovery #AmBeed #JACS
Published in #AngewandteChemieNovit: A sulfonium reagent enables an unprecedented homologative dielectrophilic activation of unactivated alkenes. By Mattia Silvi & co-workers (@SilviResearch). Read it here: https://t.co/vfNRoXylnJ
Last week we said goodbye to our postdoc @Subhasis2107 (at the other side of the table in pic). Subhasis has been a giant of the group and we wish him all the best for his future career in India!
Happy to share our latest work, a practical and iterative protocol for carboxylic acid homologation, today online in @J_A_C_S. Well done to @WheatleyEmilie and George for their exceptional work on this. https://t.co/BNxkFmtxk0
"We fail much more than we ever succeed. We know that. We accept that. We're amazing at dealing with failure. That's what scientists do."
- chemist David MacMillan (@dmac68) on failure at the #NobelPrizeDialogue in Brazil.
Watch the full dialogue: https://t.co/L3nZ8cxbq8
Such awful management by EasyJet & Schiphol Airport team: Original flight depart. time: 18:50; got delayed- EasyJet app updating depart. time 21:31 while airport display board updating 22:20; and after complete boarding at 22:00 you have to wait for 23:02 for departure #easyjet