Sc2.0

International team building the world's first designer eukaryotic genome...thinking about what's next...Synbio enthusiasts. Tweets by Sc2.0 consortium members

[Daniel Schindler @DSchindler_PDR]

Thank you for highlighting this @TwistBioscience - hope you are keen on many more synthetic chromosome/genome projects!

[BioTechniques @MyBioTechniques]

A yeast strain with over 31% synthetic genome displays normal morphology and budding behavior >>> https://t.co/60THL84rff
@CellPressNews @JefBoeke @caiyizhi @SynGenome

[Uni of Nottingham Press Office @UoNPressOffice]

Scientists @BABlount @UoNLifeSci & @ProfTomEllis @Imperialcollege are poised to create the most advanced “synthetic” organism ever made — a baker’s yeast that is controlled entirely by human-made genetic instructions.

Read more @thetimes ▶️ https://t.co/aFZBVAYVKS

[Henry Lee @hhlee]

Congrats to the Sc2.0 community on this huge achievement. Just wait for our Oxytricha trifallax 2.0!!

[Cell @CellCellPress]

Now online! Design, construction, and functional characterization of a tRNA neochromosome in yeast https://t.co/mfwycdJRsE

[Ben Blount @BABlount]

We finally finished our synthetic chromosome! @ProfTomEllis @glen_gowers I'm just going to collapse in this corner now... https://t.co/7BNyHay6zD

[New Scientist @newscientist]

A strain of yeast has had half its DNA replaced with artificial chromosomes in a major step towards creating the first complex cell with an entirely synthetic genome https://t.co/JltGo6Wxje

[Cell @CellCellPress]

Now online! Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions https://t.co/fAP4OcrTyP

[SynBioBeta @SynBioBeta]

Researchers have achieved a significant milestone by successfully integrating more than seven synthetic chromosomes into a single yeast cell, yielding a strain with over 50% synthetic DNA that can survive and replicate similarly to wild yeast strains: https://t.co/Kerj85WVj3

[Roy Walker @SynbioRoy]

It’s a great pleasure to see the tRNA neochromosome finally reaching the light of day at @CellCellPress! I’m sharing co-first authorship with @DSchindler_PDR, with @caiyizhi at the helm and under the guidance of @JefBoeke. Find the article here: https://t.co/yjGYGIWdPq

[Thomas Williams @Dr_Tom_Williams]

Congratulations to all the consortium members for their hard work and contributions towards a landmark achievement in synthetic biology! @PaulsenLab @SynGenome

[Thomas Williams @Dr_Tom_Williams]

How do you build a synthetic yeast genome with thousands of designed changes and a new-to-nature genome diversification ‘scramble-ing’ mechanism?

[nature @Nature]

Biologists have produced a strain of yeast whose genome is more than 50% synthetic DNA https://t.co/XSRsx0VfZk

[Cell Press @CellPressNews]

“Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast” @CellGenomics https://t.co/saaGbVe3EN

@caiyizhi

[Cell Press @CellPressNews]

“Design, Construction, and Functional Characterization of a tRNA Neochromosome in Yeast” @cellcellpress https://t.co/XmtFjMZnmE

@caiyizhi

[Cell Press @CellPressNews]

#Yeast cell created with an over 50% synthetic #genome can survive and replicate similar to wild type.

See below a collection of papers presenting this half-synthetic yeast and showcasing the #SyntheticYeastGenomeProject (Sc2.0) @yeastgenome 🧵

[Judith Nicholson @JudeNicho]

Very proud of our November issue presenting the amazing work by the Sc2.0 consortium. Took me back to my #igem (2006) roots and I know this collection will be a landmark in synthetic biology. https://t.co/EfetEUJnDD

[SGD Project @[email protected] (bsky too) @yeastgenome]

Check it out now in #Cell #Genomics Open Access - Rise of synthetic #yeast: Charting courses to new applications https://t.co/HoFi2RNpoV

[Cell Press @CellPressNews]

“Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains” @CellGenomics https://t.co/kEH3tWTp5Z

@JohnsHopkinsSPH Srinivasan Chandrasegaran @JefBoeke @WEIMINZHANG6

[The University of Manchester News @UoMNews]

An international team of scientists led by @caiyizhi are one step closer to re-writing world’s first synthetic yeast genome.

The Sc2.0 team have now recreated every chromosome in baker's yeast from scratch and combined 6.5 of them in a functional cell.

👉https://t.co/1ekaTk81QC