Are we beginning to understand the conversations your brain is having during Parkinson's pain? Do we know why pain in Parkinson’s is different? Even people with Parkinson’s who say they are not in pain may still show abnormal brain pain responses. Pain in Parkinson’s has long been overlooked, however new evidence shows the brain itself may struggle to turn down the volume on 'painful signals.' Using electrophysiology, researchers have uncovered altered central pain modulation in people w/ Parkinson’s, even in those who did not report pain. This work deepens our understanding of why pain is so common and difficult to treat in Parkinson’s.
Key Points:
- Persons w/ Parkinson’s showed impaired habituation to repeated painful stimuli, a sign of disrupted central pain modulation.
- This abnormal brain response occurred regardless of whether persons reported having pain.
- The findings suggest central sensitization mechanisms may be at play in Parkinson’s.
- This highlights some of dopamine’s role in pain pathways.
My take: If we are to treat Parkinson's pain we must make the investment to understand its pathways. Here are 5 points that resonated w/ me about this article. 1-Pain in Parkinson’s is not just in the body, it is also in the brain’s pain networks. 2- The brain normally gets used to repeated pain, however in Parkinson’s this process is disrupted. 3- Even people with Parkinson’s who say they are not in pain may still show abnormal brain pain responses. 4- Understanding these brain changes can help us to develop better pain treatments tailored to Parkinson’s. 5- Recognizing pain as part of Parkinson’s will be essential for developing therapeutics.
https://t.co/0SB72O0e7f #parkinson @ParkinsonDotOrg@PainAssocScot@painsociety@FixelInstitute@movedisorder@SfNtweets@MDJ_Journal
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North Carolina woman yanks the hair of a young pickpocket in Venice, Italy, causing the suspected thief to have a screaming meltdown.
The mother of 8 tracked down the suspect by using the ‘Find My’ app to locate the missing AirPods and her passport.
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The mom ended up getting her passport and credit cards back.
This woman is a beast.
Video: karismcelroy / tt
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