Li Tang

#Immunoengineering for better therapies | Associate Prof. of BioE @EPFL | Associate Editor @ESMO_IOTECH | Co-founder of @LemanBiotech

[Li Tang @Tang_Lab_EPFL]

Thrilled to share our back-to-back two Nature @Nature papers on the unexpected role of type 2 immunity against cancer. We found that interleukin 4 (Fc–IL-4), a type 2 cytokine, reinvigorates exhausted T cells to potentiate anticancer immunotherapy w/ @YugangGUO2 @RongFan8(1/11)

[Xu Zhou (周旭) @XuZhouLab]

Beyond excited to share our #NewPaper in @CellCellPress! Inflamed environments acidify intracellular pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of inflammation. #inflammation #pH https://t.co/VMQmTxQgLM

[Li Tang @Tang_Lab_EPFL]

Excited to attend and speak at FOCIS 20225 next week! @Focis_FCE @focisimmunology #FOCIS #FOCIS2025 https://t.co/rHSxVAigpU

[Li Tang @Tang_Lab_EPFL]

@Zhiliang_Bai @carlhjune @GruppSteve @MelenhorstLab @deniswirtz @YiXing77 @DrMingyaoLi @StimulatedRaman @wang_yingxiao Congratulations! what a wonderful start. Look forward to seeing the great science from Bai lab!

[Li Tang @Tang_Lab_EPFL]

The Yin-Yang of metabolic modulation for improving cancer immunotherapy - check our most recent review article on metabolic immunoengineering! Kudos to my former postdoc Bing Feng, now PI at Hangzhou Inst of Medicine, and PhD students Rongrong @RRLi11606739 and Weilin @Weiliin_L

[Li Tang @Tang_Lab_EPFL]

@XuZhouLab @MIT @NeurIPSConf well said 👍

[CPMM @CPMM2424]

We are excited to kick off our Forces at Play: Molecular Mechanobiology Seminar Series with Dr. Cheng Zhu from the Georgia Institute of Technology on January 16th at 12pm EST.
If you aren't already on our distribution list, please register below for the Zoom link!

[Li Tang @Tang_Lab_EPFL]

Many congratulations to Michele! @Materials_EPFL @MicheleCeriotti

[Harvard Chemistry @HarvardCCB]

Congratulations to @MicheleCeriotti for delivering his E. Bright Wilson Prize Lecture on machine learning for chemistry at @HarvardCCB! https://t.co/yjUWxonhhV #chemtwitter

[Can Aztekin @CanAztekin]

Interested in working with 🐸, 🐭, stem cells, or computational methods 🖥️ to delve into the unknowns of regeneration in our new lab? Looking forward to enthusiastic and ambitious applicants! PhD program applications open! 🔗 https://t.co/eEBR4ot6Ty Please RT! 🙌

[Li Tang @Tang_Lab_EPFL]

Beautiful illustration of E-CAR T cell👍A new way to engineer CAR T cells. Congrats, Chenqi, Haopeng, and the team👏

[Chenqi Xu @ChenqiXuSH]

Glad to share our new publication @ImmunityCP , reporting a new E-CAR that can form mature immunological synapse through phase separation. Paper link: https://t.co/CsQrN2fzNA

[Li Tang @Tang_Lab_EPFL]

@yizhoudonglab @EricJNestler @aw_charney @Ramon_Parsons @NatureBiotech @IcahnMountSinai @IcahnInstitute @SinaiImmunol @SinaiBrain @TischCancer @BMEIIsinai congratulations, Yizhou!

[Gioele La Manno @GioeleLaManno]

Interested in #singlecell and #spatial #metabolomics ? Then book your calendar for December 10th! – Our online, free event will summarize major achievements of the field in 2024. #metabolism #omics #MALDI #EPFL With @Gio_Dangel0 lab we prepared a fantastic lineup. 🧵 1/5

[Dr. Patrick Hwu @PatrickHwuMD]

#ScienceSaturday

❓ How can we enhance CAR-T cell activity against solid cancers?

➡️ In a recent study, Zhao et al transduced CAR-T to express IL-10, resulting in enhanced T-cell proliferation, effector function, mitochondrial capacity and antitumor activity in a variety of solid tumor murine models.

‼️ This exciting approach holds promise for patients with solid malignancies.

Here’s a link to the full article- https://t.co/OdN9ugsKz7

@Tang_Lab_EPFL @YugangGUO2 @ZJU_China @DrFredLocke @MarcoRuella @BReinfeld @RPachynski @DrBetofMDPhD

[Li Tang @Tang_Lab_EPFL]

@PatrickHwuMD Many thanks for highlighting our work, Patrick！

[Li Tang @Tang_Lab_EPFL]

@RongFan8 congratulations! the cover is neat and pretty 👏

[Li Tang @Tang_Lab_EPFL]

@IrvingMelita @NatureBiotech @myESMO @ASH_hematology Many thanks, Melita!

[Li Tang @Tang_Lab_EPFL]

We make it to the cover @NatureBiotech! the IL-10-CAR-T cells eradicate solid tumors! https://t.co/hpFUqyuRGD The IL-10-CD19-CAR-T cells have shown promising clinical results in several investigator initiated trials too. Stay tuned! #SOHC @myESMO @ASH_hematology

[Nature Biotechnology @NatureBiotech]

The November issue is live https://t.co/Oh3jSUkWXw

On our cover, Zhao et al. show that expressing IL-10 in CAR T cells improves their mitochondrial function and therapeutic efficacy in multiple solid-tumor models https://t.co/Sg45YuyQx3

[Li Tang @Tang_Lab_EPFL]

This cover art was based on real TEM images of mitochondria of exhausted CAR-T cells reinvigorated by IL-10. Kudos to Yiling Li, a PhD student of my former postdoc, Prof. Yugang Guo @YugangGUO2 @ZJU_China

[Li Tang @Tang_Lab_EPFL]

Credit to Vincent van Gogh as we were inspired by his famous painting 'The Starry Night' obviously 😀

[Li Tang @Tang_Lab_EPFL]

@Singleron_Bio @NatureBiotech @myESMO @ASH_hematology Many thanks!

[Li Tang @Tang_Lab_EPFL]

@Yoon_Seok_Kim @NatureBiotech @myESMO @ASH_hematology Many thanks, Yoon!

[Li Tang @Tang_Lab_EPFL]

@RongFan8 @NatureBiotech @myESMO @ASH_hematology Thanks, Rong!