Target 2035

🌍 open science movement to develop by 2035 pharmacological tools for all human proteins; &

[Albert A. Antolin (he/him) @antolin_aa]

#MAINFRAME is launching! This international, #OpenScience Network brings #MachineLearning & #compchem scientists together to create open-source algorithms & benchmarks for tackling real-world challenges in #DrugDiscovery. Join us: https://t.co/xOsrQ1BFdq

[Target 2035 @target2035]

#MAINFRAME is an #OpenScience Network, supported by Target2035 & ultra-large-scale experimental screening data, brings #MachineLearning & #compchem scientists together to create open-source algorithms & benchmarks tackling #DrugDiscovery challenges.
https://t.co/TRk15sZ7Lz

[Structural Genomics Consortium (SGC) @thesgconline]

New episode for our Target 2035 Podcast Series 🎧
@MilkaKostic talks with @aledmedwards to unpack his journey from a traditional research scientist to a passionate open science advocate.

Listen here: https://t.co/JUI5VWMQ79

[Structural Genomics Consortium (SGC) @thesgconline]

A fully open framework for DEL-ML hit discovery. We replace explicit DEL compound structures with ML-ready chemical fingerprints, enabling the broad scientific community to advance DEL-ML models and refine discovery methods. All data available on AIRCHECK.
https://t.co/fg3lyssOpf

[Structural Genomics Consortium (SGC) @thesgconline]

A well anticipated overview highlighting the first CACHE challenge, which brought together 23 research teams from 10 countries to collectively predict 1,955 compounds targeting LRRK2-a protein linked to #ParkinsonsDisease.

https://t.co/5P4SAMcmOy

[Chemical Probes Portal @Chemical_probes]

🚨 New publication alert! 🚨
Our latest update on the Chemical Probes Portal is live! 🎉

📜 Read the paper: https://t.co/idifAiYU4t
🔍 Learn about our expanded content + improved functionality in the 2024 Nucleic Acids Research Database Issue.
#ChemicalProbes #BiomedicalResearch

[RSC Medicinal Chemistry @rsc_medchem]

📢RSC Medicinal Chemistry is delighted to announce our newest Associate Editor, Dr Susanne Müller-Knapp from @goetheuni!

📰Read our blog for more about Susanne: https://t.co/2BhTY2Q4a7

👀Submit to her today: https://t.co/qoVUSK7Fxz

@Chemical_probes @thesgconline

[Target 2035 @target2035]

Just Launched! Episode 1 of the Target 2035 Podcast Series🎧 In the debut episode, @LabScribbles welcomes @CherylArrowsmi1, a leading scientist in chemical biology and one of the initiators of Target 2035.
https://t.co/CAChqSQKrU
#Target2035 #OpenScience #DrugDiscovery

[Target 2035 @target2035]

🎙️ The Target 2035 podcast series is officially LIVE!
In our pilot episode, meet our hosts - @MilkaKostic, @LabScribbles and Opher Gileadi who share their personal motivations for joining the Target 2035 initiative.
Tune in to the pilot episode now! https://t.co/HVvdc6mLkb 🎧

[Target 2035 @target2035]

🎙️ Get ready... Something BIG is coming from Target 2035! What if the future of drug discovery could be unlocked by listening in? @LabScribbles, @MilkaKostic and Opher Gileadi got something brewing, and trust us- you won’t want to miss it!
#Target2035, #OpenScience, #ComingSoon

[Keith Hornberger @KRHornberger]

The short history of NSD2 degraders has been a little fuzzy with some odd mechanisms of action so far, but this one seems a little cleaner and more potent than its forebears.
https://t.co/WgHOfce62m

[Keith Hornberger @KRHornberger]

This is a terrific and comprehensive review on molecular glues from the Arkin lab. Open access too.
https://t.co/dpbKFpNkpC

[Target 2035 @target2035]

#affinity_selection #hit_finding #drugdiscovery

[Structural Genomics Consortium (SGC) @thesgconline]

Our ASMS platform is now officially up and running! @HalabelianLab and Hui Peng, with the support of the @InnovationCA, have completed the first round of ASMS screenings for 8 proteins in just 2 weeks, including thorough hit verification.
Stay tuned for more exciting data!

[Ryan Potts @pottslab]

Nice work from Gray and @fischerlab1 labs on combinatorial libraries for CRBN molecular glue discovery that yielded a WEE1 degrader. https://t.co/V0T7QjqLny

[BryanRoth @zenbrainest]

Wow!! Congratulations @BShoichet and others.

[Target 2035 @target2035]

Need a #chemicalprobe?
@chemical_probes has reached 1000 chemical tools that have been reviewed by #drugdiscovery experts.

[Structural Genomics Consortium (SGC) @thesgconline]

Kudos to @Chemical_probes for reaching 1,000 compounds! A great collaboration with @target2035 to expedite chemical probe discovery.

[Target 2035 @target2035]

#AstraZeneca publishes on the challenges and impact on developing #highthroughput #thermalshift based #drugdiscovery
High-throughput differential scanning fluorimetry (DSF) and cellular t... https://t.co/mLYspoiXIc

[Structural Genomics Consortium (SGC) @thesgconline]

Stefan Knapp and Susanne Muller talk about how different stakeholders can contribute to high-quality research using small molecule tools.
https://t.co/y2JvXBnEff

[Structural Genomics Consortium (SGC) @thesgconline]

We are happy to share that @target2035 will be featured in the upcoming @ChemBioSociety 2023 with a scientific session chaired by @CherylArrowsmi1. Among the speakers will be our very own @mattschap and Serah Kimani from @HalabelianLab.
More details: https://t.co/X3haRMI7Jx

[Target 2035 @target2035]

A recent review by Edelris and AstraZeneca on "Affinity selection mass spectrometry speeding drug discovery" https://t.co/A36AKeweHg