Jessica

Stage IV colon cancer patient.
Mom of 3.
Wife.
Runner.
Lover of the outdoors.
Clinical Trial participant.
Equity and access ally.
LIVING with cancer.
Go Ags!

[Jessica @TenaciousJess]

@pashtoonkasi @oncologynursing @CCO_Education @OncoAlert @marklewismd @aparna1024 @PamelaKunzMD @OncoThor @doctorC369 @BenWestphalen @clacardone @profevasegelov @BrandonMeyersMD @GillSharlene As a g12c patient who has experienced acquired resistance to a g12ci: if a g12c patient has interest in participating in g12c trials, this would be good to know/do early in order to save 2L chemo for use after trial/@ resistance.

Not sure if this counts though as it's not SOC.

[Jessica @TenaciousJess]

If you go into a place people HAVE to go (especially for cancer care), just put your dang mask on over your mouth AND nose.

It's a weird power flex to go around a bunch of cancer patients & nonverbally communicate your confidence in your health. This isn't your moment, cover up.

[A.n.n. @fireflyann]

Dear @ASCO @esmo @AACR

Can we have a ribbon/badge for Trial Particpants?

Not sure what the color is for
*** Fearless ***

#GI22
@AdvocateCollab @marklewismd @TenaciousJess @KRASKickers @EnvRhet @itsnot_pink @coffeemommy @BrendaS104 @Globeseek @gulleyj1 @skopetz @FightCRC

[Jessica @TenaciousJess]

This whole thread is awesome. I would proudly wear those badges. I know people will live longer because I volunteered.

Now let's find another one to help me and the rest of us who said "yes" to early phase/monotherapy trials.

[A.n.n. @fireflyann]

@itsnot_pink @rsstruthers @ASCO @Esmo @AACR @AdvocateCollab @marklewismd @TenaciousJess @KRASKickers @EnvRhet @coffeemommy @BrendaS104 @Globeseek @gulleyj1 @skopetz @FightCRC When I first thought of this, I was thinking of girl scout badges for my friend. @TenaciousJess

FiH
Interventional trial
Kras g12c (or targeted trial)
Reported research
Practice changing (one day)

[Jessica @TenaciousJess]

@marklewismd So grateful for the nuanced conversation today around ox dosing regarding cipn.

Would love to hear a similar panel talk about successful strategies for ox desense for pts who had to quit due to allergy. It's no man's land out there sometimes.

[Jessica @TenaciousJess]

@CathyEngMD @fireflyann @ASCO @KristenCiombor @VUMC_Cancer @VUMChealth @COLONTOWN1 @jordanberlin5 @drlauragoff @CardinMD @GIcancerDoc I keep thinking about the awesome females from Vanderbilt who presented this week. You are an incredible example for young women like my daughter.

[Dr. Karen Winkfield @DrWinkfield]

Why did I have to be insulted, berated & abused on an @AmericanAir flight AA2935 because I asked the person behind me to put on a mask? Thank God for flight attendant Luis. He tried, but plane forced to land in OKCity because folks 👏🏽 won’t 👏🏽 wear 👏🏽a 👏🏽mask!!! #COVID19

[Jessica @TenaciousJess]

@fireflyann One idea: bring the testing to the patients. Use mobile phlebotomy/home nursing to make it as easy as possible for patient.

And tell patients they will have access to data.

[Jessica @TenaciousJess]

@CCAlliance I'd be curious on the followup regarding mental/emotional health of caregivers if the patient does not survive.

It seems that a sudden change from life revolving around cancer could amplify the feeling of emptiness/loss.

It's a hard topic, but we cannot ignore it.

[Jessica @TenaciousJess]

Caregivers carry the weight of the world often without the same support the patient receives.

My husband has driven me 25,000 miles to/from clinical trial appointments just since July 2020, while also working full time and being an incredible dad to our kids.

25,000+ miles Wow.

[Colorectal Cancer Alliance @CCAlliance]

Only 32.5% of caregivers received help or advice from their patient’s doctors or medical team on the tasks listed.

Special thanks to @phase2 for partnering with us on these key findings. @ASCO #GI22

[Jessica @TenaciousJess]

It takes a special kind of human to attend these conferences knowing that you'll learn more about what doesn't work than does in a disease you are actively trying to survive and staying hopeful.

Kudos to all the patient advocates who have become proficient at compartmentalizing.

[Jessica @TenaciousJess]

Loved the discussion on oligometastatic disease & the mention of consideration of age as a factor in choosing treatment. As we see more young people being diagnosed, we must remember what the HOPE of making it to milestones (ie. child's graduation) can do for the spirit.

[Jessica @TenaciousJess]

@pashtoonkasi @ASCO @DavidHongMD @RonaYaeger @mgfakih @MDAndersonNews @drgandara @GIcancerDoc @NiuSanford @realbowtiedoc @manjuggm @FightCRC Good to know!

[Jessica @TenaciousJess]

@pashtoonkasi @ASCO @DavidHongMD @RonaYaeger @mgfakih @MDAndersonNews @drgandara @GIcancerDoc @NiuSanford @realbowtiedoc @manjuggm @FightCRC Given the tolerability of Sotorasib, any idea if there will be even more potential combinations?

Especially for those who are chemo-refractory/allergic/intolerant.

OR

Any early indication that adding Sotorasib to a previously failed chemo may resensitize?

[Jessica @TenaciousJess]

@pashtoonkasi @ASCO @DavidHongMD @RonaYaeger @mgfakih @MDAndersonNews @drgandara @GIcancerDoc @NiuSanford @realbowtiedoc @manjuggm @FightCRC So many of us are eagerly awaiting ability to try these combinations if we can't access them on trial (exclusion criteria or other limiting factors). Hoping to see ability to access (especially for former trial particiapants) soon.

[Jessica @TenaciousJess]

@DrLauraPorter @ASCO This would be so good for monitoring FIH clinical trial participants especially.

[Jessica @TenaciousJess]

@marklewismd @JIPOEditors This is what I have been talking about. We need to think of trial participants as a valuable, HUMAN, member of the team.

Thank them by including them and you will see more people signing up to participate.

Sometimes it is forgotten that research can't happen without us!

[Jessica @TenaciousJess]

@coloncancergal @ASCO @CCAlliance @jtel09 So sad I wasn't able to go to the expo. But you have some great representation there. 😍

[Kelly Araujo @KellyBorgesAra2]

KRISTAL-1 trial presented at #GI22 is really surprising: 100% of DCR in PDAC/BTC with KRAS G12C mutation. Hopefully in the near future the personalized medicine for PDAC will not be the exception.
🙂BRCAm1/2 germ: 5-7%;
🥺MMRd:<5%;
😐NRG1-fusion <1%;
😃KRASm:90%
😶KRAS G12C<1%